Gene/Proteome Database (LMPD)

LMPD ID
LMP012772
Gene ID
81761
Species
Rattus norvegicus (Rat)
Gene Name
arginyl aminopeptidase (aminopeptidase B)
Gene Symbol
Rnpep
Alternate Names
aminopeptidase B; AP-B; RNPEP; arginine aminopeptidase; cytosol aminopeptidase IV;
Chromosome
13
Map Location
13q13
EC Number
3.4.11.6
Summary
binds zinc; catalyzes the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rnpep

Proteins

aminopeptidase B
Refseq ID NP_112359
Protein GI 13592047
UniProt ID O09175
mRNA ID NM_031097
Length 648
MESSGPSSCHSAARRPLHSAQAVDVASASSFRAFEILHLHLDLRAELPPGPGPGSRGLNGKATLELRCLLPEGASELRLDSHSCLEVMAATLLRGQPGDQQQLTEPVPFHTQPFSHYGQALCVVFPKPCCAAERFRLELTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFPCFDTPAVKCTYSALVEVPDGFTAVMSASTWERRGPNKFFFQMSQPIPSYLIALAIGDLASAEVGPRSRVTEPCLIEAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRISTILFGAAYTCLEAATGRALLRQHMDVSGEENPLNKLRVKIEPGVDPDDTYNETPYEKGYCFVSYLAHLVGDQEQFDKFLKAYVDEFKFQSILAEDFLEFYLEYFPELKKKGVDSIPGFEFNRWLNTPGWPPYLPDLSPGDSLMKPAEELAELWAASEPDMQAIEAVAISTWKTYQLVYFLDKILQKSPLPPGNVKKLGETYPKISNAQNAELRLRWGQIILKNDHQEEFWKVKDFLQSQGKQKYTLPLYHAMMGGSEMARTLAKETFSATASQLHSNVVNYVQQILAPKGS

Gene Information

Entrez Gene ID
81761
Gene Name
arginyl aminopeptidase (aminopeptidase B)
Gene Symbol
Rnpep
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 NAS:UniProtKB C Golgi apparatus
GO:0009897 IDA:RGD C external side of plasma membrane
GO:0005576 IDA:UniProtKB C extracellular region
GO:0005615 IDA:RGD C extracellular space
GO:0043005 IDA:RGD C neuron projection
GO:0005886 IDA:UniProtKB C plasma membrane
GO:0030141 IDA:RGD C secretory granule
GO:0004177 IDA:UniProtKB F aminopeptidase activity
GO:0050897 IDA:RGD F cobalt ion binding
GO:0005507 IDA:RGD F copper ion binding
GO:0070006 IDA:RGD F metalloaminopeptidase activity
GO:0042277 IDA:RGD F peptide binding
GO:0008270 NAS:UniProtKB F zinc ion binding
GO:0007568 IEP:RGD P aging
GO:0019370 IEA:InterPro P leukotriene biosynthetic process
GO:0045776 IMP:RGD P negative regulation of blood pressure
GO:0016485 NAS:UniProtKB P protein processing
GO:0006508 IC:UniProtKB P proteolysis
GO:0060041 IEP:RGD P retina development in camera-type eye

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR015571 Pept_M1_aminopeptidase-B
IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
arginyl aminopeptidase (aminopeptidase B)
Protein Entry
AMPB_RAT
UniProt ID
O09175
Species
Rat

Comments

Comment Type Description
Catalytic Activity Release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 zinc ion per subunit. ;
Function Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4).
Similarity Belongs to the peptidase M1 family
Subcellular Location Secreted.
Subunit Monomer.
Tissue Specificity Widely expressed.

Identical and Related Proteins

Unique RefSeq proteins for LMP012772 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592047 RefSeq NP_112359 648 aminopeptidase B

Identical Sequences to LMP012772 proteins

Reference Database Accession Length Protein Name
GI:13592047 GenBank AAB52971.1 648 aminopeptidase B [Rattus norvegicus]

Related Sequences to LMP012772 proteins

Reference Database Accession Length Protein Name
GI:13592047 GenBank AAB52971.1 648 aminopeptidase B [Rattus norvegicus]
GI:13592047 GenBank AAH61718.1 650 Arginyl aminopeptidase (aminopeptidase B) [Rattus norvegicus]
GI:13592047 SwissProt O09175.2 650 RecName: Full=Aminopeptidase B; Short=AP-B; AltName: Full=Arginine aminopeptidase; AltName: Full=Arginyl aminopeptidase; AltName: Full=Cytosol aminopeptidase IV [Rattus norvegicus]