Gene/Proteome Database (LMPD)

LMPD ID
LMP012771
Gene ID
81752
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin E receptor 2 (subtype EP2)
Gene Symbol
Ptger2
Synonyms
EP2; Ptger-ep2;
Alternate Names
prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor; PGE receptor EP2 subtype; PGE receptor, EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E2 receptor type 2; prostaglandin E receptor EP2 subtype;
Chromosome
15
Map Location
15p14
Summary
binds prostaglandin E2 and induces increased cAMP; may play a role in skeletal growth [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ptger2

Proteins

prostaglandin E2 receptor EP2 subtype
Refseq ID NP_112350
Protein GI 13592031
UniProt ID Q62928
mRNA ID NM_031088
Length 357
MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL

Gene Information

Entrez Gene ID
81752
Gene Name
prostaglandin E receptor 2 (subtype EP2)
Gene Symbol
Ptger2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004957 IDA:RGD F prostaglandin E receptor activity
GO:0007189 IEA:Ensembl P adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0071380 IEA:Ensembl P cellular response to prostaglandin E stimulus
GO:0042127 IEA:Ensembl P regulation of cell proliferation
GO:0032496 IEA:Ensembl P response to lipopolysaccharide
GO:0001501 NAS:RGD P skeletal system development

KEGG Pathway Links

KEGG Pathway ID Description
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953755 G alpha (s) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954201 Prostanoid ligand receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR001923 Prostanoid EP2 receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin E receptor 2 (subtype EP2)
Protein Entry
PE2R2_RAT
UniProt ID
Q62928
Species
Rat

Comments

Comment Type Description
Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity)
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012771 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592031 RefSeq NP_112350 357 prostaglandin E2 receptor EP2 subtype

Identical Sequences to LMP012771 proteins

Reference Database Accession Length Protein Name
GI:13592031 GenBank AAB53325.1 357 EP2 prostanoid receptor [Rattus norvegicus]
GI:13592031 GenBank AAM73855.1 357 prostaglandin E2 receptor type 2 [Rattus norvegicus]
GI:13592031 GenBank EDL88294.1 357 prostaglandin E receptor 2, subtype EP2 [Rattus norvegicus]
GI:13592031 SwissProt Q62928.1 357 RecName: Full=Prostaglandin E2 receptor EP2 subtype; Short=PGE receptor EP2 subtype; Short=PGE2 receptor EP2 subtype; AltName: Full=Prostanoid EP2 receptor [Rattus norvegicus]

Related Sequences to LMP012771 proteins

Reference Database Accession Length Protein Name
GI:13592031 GenBank AAA97889.1 357 prostaglandin E receptor EP2 subtype [Rattus norvegicus]
GI:13592031 GenBank AAM73855.1 357 prostaglandin E2 receptor type 2 [Rattus norvegicus]
GI:13592031 GenBank EDL88294.1 357 prostaglandin E receptor 2, subtype EP2 [Rattus norvegicus]