Gene/Proteome Database (LMPD)

LMPD ID
LMP012769
Gene ID
81747
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
Pi4kb
Synonyms
Pik4cb;
Alternate Names
phosphatidylinositol 4-kinase beta; PI4Kbeta; PI4K-beta; ptdIns 4-kinase beta; catalytic phosphatidylinositol 4-kinase beta; phosphatidylinositol 4-kinase, catalytic, beta polypeptide;
Chromosome
2
Map Location
2q34
EC Number
2.7.1.67;
Summary
phosphorylates phosphatidylinositol (PtdIns) at the D4 position of the inositol ring; may play a role in neuronal differentiation and maturation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pi4kb

Proteins

phosphatidylinositol 4-kinase beta
Refseq ID NP_112345
Protein GI 14389295
UniProt ID O08561
mRNA ID NM_031083
Length 816
MGDMVVEPATLKPTSEPTPSPSGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNEIRCLDDPPTEIREEEDEMEPGVVSGTAKGTRRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPTLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTNVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLNGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM

Gene Information

Entrez Gene ID
81747
Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Gene Symbol
Pi4kb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005886 IDA:RGD C plasma membrane
GO:0004430 IDA:RGD F 1-phosphatidylinositol 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006661 IEA:InterPro P phosphatidylinositol biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0007165 TAS:RGD P signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954502 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR027003 Phosphatidylinositol 4-kinase
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase, catalytic, beta
Protein Entry
PI4KB_RAT
UniProt ID
O08561
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Enzyme Regulation Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity)
Function Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Golgi apparatus {ECO:0000269|PubMed:11526106, ECO:0000269|PubMed:19458041, ECO:0000269|PubMed:8973579}. Endomembrane system . Mitochondrion outer membrane ; Peripheral membrane protein . Rough endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex (By similarity)
Subunit Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium- dependent manner. Interacts in a calcium-independent manner with NCS1/FREQ. This binding competes with CALN1/CABP8 and CALN2/CABP7 binding. Interacts with ARF1 and ARF3 (By similarity)
Tissue Specificity Strongly expressed in brain, kidney, lung, small intestine, uterus and adrenal gland. Weaker expression in liver, heart, skeletal muscle, thymus and testis. Not detected in spleen

Identical and Related Proteins

Unique RefSeq proteins for LMP012769 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14389295 RefSeq NP_112345 816 phosphatidylinositol 4-kinase beta

Identical Sequences to LMP012769 proteins

Reference Database Accession Length Protein Name
GI:14389295 DBBJ BAA18969.1 816 phosphatidylinositol 4-kinase [Rattus norvegicus]
GI:14389295 GenBank EDL85763.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Rattus norvegicus]
GI:14389295 GenBank EDL85764.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Rattus norvegicus]
GI:14389295 SwissProt O08561.1 816 RecName: Full=Phosphatidylinositol 4-kinase beta; Short=PI4K-beta; Short=PI4Kbeta; Short=PtdIns 4-kinase beta [Rattus norvegicus]

Related Sequences to LMP012769 proteins

Reference Database Accession Length Protein Name
GI:14389295 DBBJ BAA18969.1 816 phosphatidylinositol 4-kinase [Rattus norvegicus]
GI:14389295 GenBank EDL85763.1 816 phosphatidylinositol 4-kinase, catalytic, beta polypeptide, isoform CRA_a [Rattus norvegicus]
GI:14389295 SwissProt O08561.1 816 RecName: Full=Phosphatidylinositol 4-kinase beta; Short=PI4K-beta; Short=PI4Kbeta; Short=PtdIns 4-kinase beta [Rattus norvegicus]