Gene/Proteome Database (LMPD)

LMPD ID
LMP012768
Gene ID
81746
Species
Rattus norvegicus (Rat)
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Gene Symbol
Pggt1b
Alternate Names
geranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I); geranylgeranyl transferase type I subunit beta; type I protein geranyl-geranyltransferase subunit beta;
Chromosome
18
Map Location
18q11
EC Number
2.5.1.59
Summary
catalyzes the transfer of a geranylgeranyl group to the cysteine residue of proteins containing a carboxyl-terminal CAAX where X is preferably leucine [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pggt1b

Proteins

geranylgeranyl transferase type-1 subunit beta
Refseq ID NP_112344
Protein GI 13592025
UniProt ID P53610
mRNA ID NM_031082
Length 377
MAATEDDRLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLDRCGFRGSSYLGIPFNPSKNPGTAHPYDSGHIAMTYTGLSCLIILGDDLSRVDKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAISYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLRDLHQSWKTKDSKQCSDNVHISS

Gene Information

Entrez Gene ID
81746
Gene Name
protein geranylgeranyltransferase type I, beta subunit
Gene Symbol
Pggt1b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005953 IDA:UniProtKB C CAAX-protein geranylgeranyltransferase complex
GO:0004662 IDA:UniProtKB F CAAX-protein geranylgeranyltransferase activity
GO:0004661 ISS:UniProtKB F protein geranylgeranyltransferase activity
GO:0008270 IDA:UniProtKB F zinc ion binding
GO:0051771 IMP:RGD P negative regulation of nitric-oxide synthase biosynthetic process
GO:0045787 IMP:RGD P positive regulation of cell cycle
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0018344 IDA:UniProtKB P protein geranylgeranylation
GO:0034097 IMP:RGD P response to cytokine

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
protein geranylgeranyltransferase type I, beta subunit
Protein Entry
PGTB1_RAT
UniProt ID
P53610
Species
Rat

Comments

Comment Type Description
Catalytic Activity Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670};
Function Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of proteins with the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B
Interaction Q04631:Fnta; NbExp=5; IntAct=EBI-602610, EBI-602447;
Similarity Belongs to the protein prenyltransferase subunit beta family
Similarity Contains 4 PFTB repeats
Subunit Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15248757, ECO:0000269|PubMed:15451670}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012768 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592025 RefSeq NP_112344 377 geranylgeranyl transferase type-1 subunit beta

Identical Sequences to LMP012768 proteins

Reference Database Accession Length Protein Name
GI:13592025 GenBank EDM14382.1 377 protein geranylgeranyltransferase type I, beta subunit [Rattus norvegicus]
GI:13592025 PDB 1TNZ 377 Chain H, Rat Protein Geranylgeranyltransferase Type-I Complexed With A Ggpp Analog And A Rrcvll Peptide Derived From Cdc42 Splice Isoform-2
GI:13592025 PDB 1TNZ 377 Chain J, Rat Protein Geranylgeranyltransferase Type-I Complexed With A Ggpp Analog And A Rrcvll Peptide Derived From Cdc42 Splice Isoform-2
GI:13592025 PDB 1TNZ 377 Chain L, Rat Protein Geranylgeranyltransferase Type-I Complexed With A Ggpp Analog And A Rrcvll Peptide Derived From Cdc42 Splice Isoform-2

Related Sequences to LMP012768 proteins

Reference Database Accession Length Protein Name
GI:13592025 PDB 1S64 377 Chain D, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion
GI:13592025 PDB 1S64 377 Chain F, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion
GI:13592025 PDB 1S64 377 Chain H, Rat Protein Geranylgeranyltransferase Type-I Complexed With L-778,123 And A Sulfate Anion