Gene/Proteome Database (LMPD)

LMPD ID
LMP012765
Gene ID
81727
Species
Rattus norvegicus (Rat)
Gene Name
mevalonate kinase
Gene Symbol
Mvk
Synonyms
Lrbp;
Alternate Names
mevalonate kinase; MK; LHR mRNA binding protein;
Chromosome
12
Map Location
chromosome:12
EC Number
2.7.1.36;
Summary
kinase that catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate; involved in the cholesterol biosynthetic pathway [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Mvk

Proteins

mevalonate kinase
Refseq ID NP_112325
Protein GI 13592007
UniProt ID P17256
mRNA ID NM_031063
Length 395
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL

Gene Information

Entrez Gene ID
81727
Gene Name
mevalonate kinase
Gene Symbol
Mvk
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0005777 IDA:UniProtKB C peroxisome
GO:0005524 IDA:RGD F ATP binding
GO:0003729 IDA:RGD F mRNA binding
GO:0004496 IDA:RGD F mevalonate kinase activity
GO:0006695 TAS:RGD P cholesterol biosynthetic process
GO:0019287 IDA:RGD P isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0008299 IDA:RGD P isoprenoid biosynthetic process
GO:0006720 TAS:RGD P isoprenoid metabolic process
GO:0017148 IDA:RGD P negative regulation of translation
GO:0045540 NAS:RGD P regulation of cholesterol biosynthetic process
GO:0016125 TAS:RGD P sterol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
rno01100 Metabolic pathways
ko04146 Peroxisome
rno04146 Peroxisome
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006204 GHMP kinase N-terminal domain
IPR006203 GHMP kinase, ATP-binding, conserved site
IPR013750 GHMP kinase, C-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
mevalonate kinase
Protein Entry
KIME_RAT
UniProt ID
P17256
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
Disease Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
Enzyme Regulation Farnesyl- and geranyl-pyrophosphates are competitive inhibitors.
Function May be a regulatory site in cholesterol biosynthetic pathway.
Miscellaneous The authors of PubMed:14730012 identify two forms of Mvk in rat liver, one form localizes to the cytosol and the other form to the peroxisome, whereas according to the authors of PubMed:14730012 the protein is found only in the cytoplasm with no evidence for its peroxisomal localization.
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily
Subcellular Location Cytoplasm. Peroxisome.
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012765 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592007 RefSeq NP_112325 395 mevalonate kinase

Identical Sequences to LMP012765 proteins

Reference Database Accession Length Protein Name
GI:13592007 GenBank EDM13937.1 395 mevalonate kinase, isoform CRA_a [Rattus norvegicus]
GI:13592007 GenBank ADI53346.1 395 Sequence 4 from patent US 7422884
GI:13592007 GenBank AGD02019.1 395 Sequence 32 from patent US 8338155
GI:13592007 PDB 2R42 395 Chain A, The Biochemical And Structural Basis For Feedback Inhibition Of Mevalonate Kinase And Isoprenoid Metabolism

Related Sequences to LMP012765 proteins

Reference Database Accession Length Protein Name
GI:13592007 GenBank EDM13937.1 395 mevalonate kinase, isoform CRA_a [Rattus norvegicus]
GI:13592007 GenBank ADI53346.1 395 Sequence 4 from patent US 7422884
GI:13592007 GenBank AGD02019.1 395 Sequence 32 from patent US 8338155