Gene/Proteome Database (LMPD)

LMPD ID
LMP012734
Gene ID
65984
Species
Rattus norvegicus (Rat)
Gene Name
acetoacetyl-CoA synthetase
Gene Symbol
Aacs
Alternate Names
acetoacetyl-CoA synthetase; AcAc-CoA ligase; acetoacetyl-CoA ligase; acetoacetate-CoA ligase;
Chromosome
12
Map Location
12q14
EC Number
6.2.1.16;
Summary
activates acetoacetate to its CoA ester [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Aacs

Proteins

acetoacetyl-CoA synthetase
Refseq ID NP_075592
Protein GI 12831227
UniProt ID Q9JMI1
mRNA ID NM_023104
Length 672
MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYDDLYHWSVRSYSDFWAEFWKFSGIVCSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIAKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSMFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHVLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPMETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSTVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKTVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKYPGVWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKHIRDAIRLGLSARHVPSLILETQGIPYTINGKKVEVAVKQVIAGKTVEHRGAFSNPESLDLYRDIPELQDF

Gene Information

Entrez Gene ID
65984
Gene Name
acetoacetyl-CoA synthetase
Gene Symbol
Aacs
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0030729 IDA:RGD F acetoacetate-CoA ligase activity
GO:0047760 IDA:RGD F butyrate-CoA ligase activity
GO:0060612 IEP:RGD P adipose tissue development
GO:0071397 IEP:RGD P cellular response to cholesterol
GO:0071333 IMP:RGD P cellular response to glucose stimulus
GO:0071394 IEP:RGD P cellular response to testosterone stimulus
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process
GO:0001889 IDA:RGD P liver development
GO:0032024 IMP:RGD P positive regulation of insulin secretion
GO:0042493 IDA:RGD P response to drug
GO:0045471 IDA:RGD P response to ethanol
GO:0007584 IDA:RGD P response to nutrient
GO:0034201 IDA:RGD P response to oleic acid
GO:0014070 IDA:RGD P response to organic cyclic compound
GO:0010243 IDA:RGD P response to organonitrogen compound
GO:0014074 IEP:RGD P response to purine-containing compound
GO:0042594 IEP:RGD P response to starvation
GO:0050872 IEP:RGD P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR005914 Acetoacetyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
acetoacetyl-CoA synthetase
Protein Entry
AACS_RAT
UniProt ID
Q9JMI1
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA
Function Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Subcellular Location Cytoplasm, cytosol .
Tissue Specificity Abundant in male subcutaneous white adipose tissue after weaning. In white adipose tissue, it is preferentially detected in mature adipocytes but not in preadipocytes. The expression in primary preadipocytes increases during the adipocyte differentiation. In brain, it is expressed in the midbrain, pons/medulla, cerebral cortex, hippocampus and cerebellum. The expression in the cerebellum is restricted primarily to glial cells, while in the cerebral cortex, it is restricted to neuronal cells. {ECO:0000269|PubMed:15992942, ECO:0000269|PubMed:16055091}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012734 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12831227 RefSeq NP_075592 672 acetoacetyl-CoA synthetase

Identical Sequences to LMP012734 proteins

Reference Database Accession Length Protein Name
GI:12831227 GenBank ABY09485.1 672 Sequence 80 from patent US 7301016
GI:12831227 GenBank ADS47662.1 672 Sequence 37 from patent US 7799898
GI:12831227 GenBank AED35489.1 672 Sequence 154 from patent US 7879989
GI:12831227 GenBank AFQ88735.1 672 Sequence 37 from patent US 8252915

Related Sequences to LMP012734 proteins

Reference Database Accession Length Protein Name
GI:12831227 GenBank ADS47662.1 672 Sequence 37 from patent US 7799898
GI:12831227 GenBank AED35489.1 672 Sequence 154 from patent US 7879989
GI:12831227 SwissProt Q9JMI1.1 672 RecName: Full=Acetoacetyl-CoA synthetase [Rattus norvegicus]