Gene/Proteome Database (LMPD)

LMPD ID
LMP012724
Gene ID
65035
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 1, group I, member 3
Gene Symbol
Nr1i3
Synonyms
CAR;
Alternate Names
nuclear receptor subfamily 1 group I member 3; constitutive androstane receptor; strain Fischer nuclear receptor (CAR); nuclear receptor constitutive active receptor;
Chromosome
13
Map Location
13q24
Summary
regulatory factor that leads to the sexual dimorphic induction of CYP2B1 gene [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr1i3

Proteins

nuclear receptor subfamily 1 group I member 3 isoform 1
Refseq ID NP_075230
Protein GI 12621108
UniProt ID Q9QUS1
mRNA ID NM_022941
Length 358
MTATLTLETMTSEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQARRRAQKASLQLSQQQKELIQTLLGAHTRHVGPMFDQFVQFRPPAYLFSHHRPFQPLAPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTQNFFCGPLCYKMEDAVHVGFQYEFLELIIHFHKTLKRLQLQEPEYALMAAMALFSPDRPGVTQREEIDQLQEEVALILNNHIMEQQSRLQSRFLYAKLMGLLAELRSINSAYSYEIHRIQGLSAMMPLLGEICS
nuclear receptor subfamily 1 group I member 3 isoform 2
Refseq ID NP_001257769
Protein GI 399220348
UniProt ID Q5FVU7
mRNA ID NM_001270840
Length 315
MTATLTLETMTSEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQARRRAQKASLQLSQQQKELIQTLLGAHTRHVGPMFDQFVQFRPPAYLFSHHRPFQPLAPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTQNFFCGPLCYKMEDAVHGFQYEFLELIIHFHKTLKRLQLQEPEYALMAAMALFSPDRPGVTQREEIDQLQEEVALILNNHIMEQQSRLQSR
nuclear receptor subfamily 1 group I member 3 isoform 3
Refseq ID NP_001257767
Protein GI 399220344
UniProt ID Q5FVU7
mRNA ID NM_001270838
Length 316
MTATLTLETMTSEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQARRRAQKASLQLSQQQKELIQTLLGAHTRHVGPMFDQFVQFRPPAYLFSHHRPFQPLAPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTQNFFCGPLCYKMEDAVHVGFQYEFLELIIHFHKTLKRLQLQEPEYALMAAMALFSPDRPGVTQREEIDQLQEEVALILNNHIMEQQSRLQSR
nuclear receptor subfamily 1 group I member 3 isoform 4
Refseq ID NP_001257768
Protein GI 399220346
UniProt ID Q5FVU7
mRNA ID NM_001270839
Length 298
MTATLTLETMTSEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQARRRAQKASLQLSQQQKELIQTLLGAHTRHVGPMFDQFVQFRPPAYLFSHHRPFQPLAPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTQNFFCGPLCYKMEDAVHVGFQYEFLELIIHFHKTLKRLQLQEPEYALMAAMALFSPGLGLPKEKRLISCRKRSR

Gene Information

Entrez Gene ID
65035
Gene Name
nuclear receptor subfamily 1, group I, member 3
Gene Symbol
Nr1i3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0000977 IEA:Ensembl F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 IEA:Ensembl F RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0004887 IEA:InterPro F thyroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0045892 IEA:Ensembl P negative regulation of transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group I, member 3
UniProt ID
Q9QUS1
Species
Rat

Comments

Comment Type Description
Similarity Belongs to the nuclear hormone receptor family
Similarity Contains nuclear receptor DNA-binding domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012724 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12621108 RefSeq NP_075230 358 nuclear receptor subfamily 1 group I member 3 isoform 1
399220348 RefSeq NP_001257769 315 nuclear receptor subfamily 1 group I member 3 isoform 2
399220344 RefSeq NP_001257767 316 nuclear receptor subfamily 1 group I member 3 isoform 3
399220346 RefSeq NP_001257768 298 nuclear receptor subfamily 1 group I member 3 isoform 4

Identical Sequences to LMP012724 proteins

Reference Database Accession Length Protein Name
GI:12621108 DBBJ BAC82431.1 358 nuclear receptor [Rattus norvegicus]
GI:12621108 DBBJ BAC84955.1 358 nuclear receptor [Rattus norvegicus]
GI:399220348 DBBJ BAE19955.1 315 constitutive androstane receptor splicing variant 1 [Rattus norvegicus]
GI:399220344 DBBJ BAE19956.1 316 constitutive androstane receptor splicing variant 2 [Rattus norvegicus]
GI:399220346 DBBJ BAE19957.1 298 constitutive androstane receptor splicing variant 3 [Rattus norvegicus]
GI:399220348 GenBank AAH89763.1 315 Nr1i3 protein [Rattus norvegicus]
GI:12621108 GenBank EDL94605.1 358 nuclear receptor subfamily 1, group I, member 3, isoform CRA_a [Rattus norvegicus]
GI:399220346 RefSeq XP_008767981.1 298 PREDICTED: nuclear receptor subfamily 1 group I member 3 isoform X1 [Rattus norvegicus]
GI:12621108 SwissProt Q9QUS1.1 358 RecName: Full=Nuclear receptor subfamily 1 group I member 3; AltName: Full=Constitutive androstane receptor; Short=CAR [Rattus norvegicus]

Related Sequences to LMP012724 proteins

Reference Database Accession Length Protein Name
GI:399220348 DBBJ BAE19955.1 315 constitutive androstane receptor splicing variant 1 [Rattus norvegicus]
GI:399220344 DBBJ BAE19956.1 316 constitutive androstane receptor splicing variant 2 [Rattus norvegicus]
GI:399220346 DBBJ BAE19957.1 298 constitutive androstane receptor splicing variant 3 [Rattus norvegicus]
GI:12621108 GenBank AAF22566.1 358 nuclear receptor [Rattus norvegicus]
GI:399220344 GenBank AAF22566.1 358 nuclear receptor [Rattus norvegicus]
GI:399220344 GenBank AAF22567.1 358 nuclear receptor [Rattus norvegicus]
GI:12621108 GenBank AAF22567.1 358 nuclear receptor [Rattus norvegicus]
GI:399220348 GenBank AAH89763.1 315 Nr1i3 protein [Rattus norvegicus]
GI:399220348 RefSeq XP_006250323.1 357 PREDICTED: nuclear receptor subfamily 1 group I member 3 isoform X2 [Rattus norvegicus]
GI:399220346 RefSeq XP_008767980.1 307 PREDICTED: nuclear receptor subfamily 1 group I member 3 isoform X3 [Rattus norvegicus]
GI:399220346 RefSeq XP_008767981.1 298 PREDICTED: nuclear receptor subfamily 1 group I member 3 isoform X1 [Rattus norvegicus]
GI:12621108 SwissProt Q9QUS1.1 358 RecName: Full=Nuclear receptor subfamily 1 group I member 3; AltName: Full=Constitutive androstane receptor; Short=CAR [Rattus norvegicus]