Gene/Proteome Database (LMPD)

LMPD ID
LMP012718
Gene ID
64828
Species
Rattus norvegicus (Rat)
Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 1
Gene Symbol
B4galnt1
Synonyms
Galgt1; GalNAc-T;
Alternate Names
beta-1,4 N-acetylgalactosaminyltransferase 1; GM2/GD2 synthase; beta-4N-acetylgalactosaminyltransferase; (N-acetylneuraminyl)-galactosylglucosylceramide; UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase;
Chromosome
7
Map Location
7q22
EC Number
2.4.1.92
Summary
synthesizes both asialoglycosphingolipid GM2 and glycosphingolipid GM2 [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for B4galnt1

Proteins

beta-1,4 N-acetylgalactosaminyltransferase 1 precursor
Refseq ID NP_074051
Protein GI 12408316
UniProt ID Q10468
mRNA ID NM_022860
Length 533
MRLDRRALYALVLLLACASLGLLYASTRDAPGLPNPLALWSPPQGPPRLDLLDLATEPRYAHIPVRIKEQVVGLLAQNNCSCESSGGRFALPFLRQVRAIDFTKAFDAEELRAVSISREQEYQAFLARSRSLADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQEASVQEIYQVNLIASLGTWDVAGEVTGVTLTGEGQSDLTLASPILDKLNRQLQLVTYSSRSYQANTADTVRFSTKGHEVAFTILIRHPPNPRLYPPSSLPQGAQYNISALVTVATKTFLRYDRLRALIASIRRFYPTVTIVIADDSDKPERISDPHVEHYFMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLEKLVDVLERTPLDLVGGAVREISGYATTYRQLLSVEPGAPGFGNCLRQKQGFHHELAGFPNCVVTDGVVNFFLARTDKVRQVGFDPRLNRVAHLEFFLDGLGSLRVGSCSDVVVDHASKVKLPWTSKDPGAELYARYRYPGSLDQSQVAKHRLLFFKHRLQCMTAE
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2779 peptide sequence: MRLDRRALYALVLLLACASLGLLYA

Gene Information

Entrez Gene ID
64828
Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 1
Gene Symbol
B4galnt1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0005886 IDA:RGD C plasma membrane
GO:0003947 IEA:UniProtKB-EC F (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
GO:0008376 IDA:RGD F acetylgalactosaminyltransferase activity
GO:0001574 IEA:Ensembl P ganglioside biosynthetic process
GO:0030259 IEA:InterPro P lipid glycosylation
GO:0019915 IEA:Ensembl P lipid storage
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation
GO:0007283 IEA:Ensembl P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko00604 Glycosphingolipid biosynthesis - ganglio series
rno00604 Glycosphingolipid biosynthesis - ganglio series
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR011143 Ganglioside GM2 synthase
IPR001173 Glycosyltransferase 2-like
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
beta-1,4-N-acetyl-galactosaminyl transferase 1
Protein Entry
B4GN1_RAT
UniProt ID
Q10468
Species
Rat

Comments

Comment Type Description
Catalytic Activity UDP-N-acetyl-alpha-D-galactosamine + O-(N- acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)- beta-D-glucopyranosyl-(1<->1)-ceramide = UDP + O-2-(acetylamino)- 2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha- neuraminyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D- glucopyranosyl-(1<->1)-ceramide.
Function Involved in the biosynthesis of gangliosides GM2, GD2 and asialo-GM2.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 2 family
Subcellular Location Golgi apparatus membrane; Single-pass type II membrane protein.
Subunit Homodimer; disulfide-linked
Tissue Specificity Strongly expressed in brain, testis, spleen, and to a lesser extent in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012718 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12408316 RefSeq NP_074051 533 beta-1,4 N-acetylgalactosaminyltransferase 1 precursor

Identical Sequences to LMP012718 proteins

Reference Database Accession Length Protein Name
GI:12408316 DBBJ BAA04632.1 533 beta-4N-acetylgalactosaminyltransferase [Rattus norvegicus]
GI:12408316 GenBank AAH81799.1 533 Beta-1,4-N-acetyl-galactosaminyl transferase 1 [Rattus norvegicus]
GI:12408316 GenBank EDM16493.1 533 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_b [Rattus norvegicus]
GI:12408316 SwissProt Q10468.1 533 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 1; AltName: Full=(N-acetylneuraminyl)-galactosylglucosylceramide; AltName: Full=GM2/GD2 synthase; AltName: Full=GalNAc-T [Rattus norvegicus]

Related Sequences to LMP012718 proteins

Reference Database Accession Length Protein Name
GI:12408316 DBBJ BAA04632.1 533 beta-4N-acetylgalactosaminyltransferase [Rattus norvegicus]
GI:12408316 GenBank EDM16493.1 533 beta-1,4-N-acetyl-galactosaminyl transferase 1, isoform CRA_b [Rattus norvegicus]
GI:12408316 SwissProt Q10468.1 533 RecName: Full=Beta-1,4 N-acetylgalactosaminyltransferase 1; AltName: Full=(N-acetylneuraminyl)-galactosylglucosylceramide; AltName: Full=GM2/GD2 synthase; AltName: Full=GalNAc-T [Rattus norvegicus]