LIPID MAPS

LMPD ID

LMP012705

Gene ID

64473

Species

Rattus norvegicus (Rat)

Gene Name

3'(2'), 5'-bisphosphate nucleotidase 1

Gene Symbol

Bpnt1

Synonyms

Sal3;

Alternate Names

3'(2'),5'-bisphosphate nucleotidase 1; PIP; scHAL2 analogous 3; PAP-inositol 1,4-phosphatase; PAP-inositol-1,4-phosphatase; bisphosphate 3'-nucleotidase 1;

Chromosome

13

Map Location

13q26

EC Number

3.1.3.7

3'(2'),5'-bisphosphate nucleotidase 1
Refseq ID	NP_741987
Protein GI	25282455
UniProt ID	Q9Z1N4
mRNA ID	NM_171990
Length	308
MASSHNVLMRLVASAYSIAQKAGTIVRCVIAEGDLGIVQKTSATDLQTKADRMVQMSICSSLSRKFPKLTIIGEEDLPPGEVDQELIEDGQSEEILKQPCPSQYSAIKEEDLVVWVDPVDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAVLGRTIWGVLGLGAFGFQLKEAPAGKHIITTTRSHSNKLVTDCIAAMNPDNVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNPLQYDKEVKHMNSAGVLAALRNYEYYASRVPESVKSALIP

Entrez Gene ID

64473

Gene Name

3'(2'), 5'-bisphosphate nucleotidase 1

Gene Symbol

Bpnt1

Species

Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0070062	IEA:Ensembl	C	extracellular vesicular exosome
GO:0008441	IDA:RGD	F	3'(2'),5'-bisphosphate nucleotidase activity
GO:0004441	IDA:RGD	F	inositol-1,4-bisphosphate 1-phosphatase activity
GO:0000287	IDA:RGD	F	magnesium ion binding
GO:0016311	IDA:GOC	P	dephosphorylation
GO:0046854	IEA:InterPro	P	phosphatidylinositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID	Description
rno01100	Metabolic pathways
ko00920	Sulfur metabolism
rno00920	Sulfur metabolism

REACTOME Pathway Links

REACTOME Pathway ID	Description
5953258	Biological oxidations
5953714	Cytosolic sulfonation of small molecules
5953250	Metabolism
5953257	Phase II conjugation

InterPro Annotations

Accession	Description
IPR020550	Inositol monophosphatase, conserved site
IPR020583	Inositol monophosphatase, metal-binding site
IPR000760	Inositol_monophosphatase

Entry Information

Gene Name

3'(2'), 5'-bisphosphate nucleotidase 1

Protein Entry

BPNT1_RAT

UniProt ID

Q9Z1N4

Species

Rat

Comments

Comment Type	Description
Catalytic Activity	Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation	Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4- bisphosphate. Inhibited by calcium ions
Function	Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6
Similarity	Belongs to the inositol monophosphatase family
Tissue Specificity	Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis

Unique RefSeq proteins for LMP012705 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
25282455	RefSeq	NP_741987	308	3'(2'),5'-bisphosphate nucleotidase 1

Identical Sequences to LMP012705 proteins

Reference	Database	Accession	Length	Protein Name
GI:25282455	GenBank	AAH85692.1	308	3'(2'), 5'-bisphosphate nucleotidase 1 [Rattus norvegicus]
GI:25282455	GenBank	EDL94913.1	308	bisphosphate 3'-nucleotidase 1, isoform CRA_b [Rattus norvegicus]
GI:25282455	GenBank	EDL94918.1	308	bisphosphate 3'-nucleotidase 1, isoform CRA_b [Rattus norvegicus]
GI:25282455	RefSeq	XP_006250493.1	308	PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012705 proteins

Reference	Database	Accession	Length	Protein Name
GI:25282455	GenBank	AAH85692.1	308	3'(2'), 5'-bisphosphate nucleotidase 1 [Rattus norvegicus]
GI:25282455	GenBank	EDL94913.1	308	bisphosphate 3'-nucleotidase 1, isoform CRA_b [Rattus norvegicus]
GI:25282455	SwissProt	Q9Z1N4.1	308	RecName: Full=3'(2'),5'-bisphosphate nucleotidase 1; AltName: Full=Bisphosphate 3'-nucleotidase 1; AltName: Full=PAP-inositol 1,4-phosphatase; Short=PIP; AltName: Full=scHAL2 analogous 3 [Rattus norvegicus]