Gene/Proteome Database (LMPD)

LMPD ID
LMP012701
Gene ID
64440
Species
Rattus norvegicus (Rat)
Gene Name
synaptotagmin IV
Gene Symbol
Syt4
Alternate Names
synaptotagmin-4; sytIV; synaptotagmin 4;
Chromosome
18
Map Location
18p12
Summary
may play a role in synaptic vesicle transport; may be involved in synaptic changes in response to seizure activity [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Syt4

Proteins

synaptotagmin-4
Refseq ID NP_113881
Protein GI 13928964
UniProt ID P50232
mRNA ID NM_031693
Length 425
MAPITTSRVEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEAKRKAALPNLSLHLDLEKRDLNGNFPKTNPKAGSSSDLENVTPKLFPETEKEAVSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPVFDETFTFYGVPYPHIQELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHMLCDG

Gene Information

Entrez Gene ID
64440
Gene Name
synaptotagmin IV
Gene Symbol
Syt4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0031045 IDA:RGD C dense core granule
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043005 IEA:Ensembl C neuron projection
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0008021 NAS:RGD C synaptic vesicle
GO:0000149 IDA:RGD F SNARE binding
GO:0030276 IDA:BHF-UCL F clathrin binding
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0001786 IDA:RGD F phosphatidylserine binding
GO:0005215 IEA:InterPro F transporter activity
GO:0017156 NAS:RGD P calcium ion-dependent exocytosis
GO:0045955 IDA:RGD P negative regulation of calcium ion-dependent exocytosis
GO:0031339 IDA:RGD P negative regulation of vesicle fusion
GO:0007269 NAS:RGD P neurotransmitter secretion

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR028683 SYT4
IPR001565 Synaptotagmin

UniProt Annotations

Entry Information

Gene Name
synaptotagmin IV
Protein Entry
SYT4_RAT
UniProt ID
P50232
Species
Rat

Comments

Comment Type Description
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ;
Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
Interaction P49187:Mapk10; NbExp=2; IntAct=EBI-540118, EBI-7155513; P49185:Mapk8; NbExp=5; IntAct=EBI-540118, EBI-7456505;
Similarity Belongs to the synaptotagmin family
Similarity Contains 2 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012701 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13928964 RefSeq NP_113881 425 synaptotagmin-4

Identical Sequences to LMP012701 proteins

Reference Database Accession Length Protein Name
GI:13928964 GenBank AAY75699.1 425 Sequence 5 from patent US 6900022
GI:13928964 GenBank EDL76165.1 425 synaptotagmin IV, isoform CRA_a [Rattus norvegicus]
GI:13928964 GenBank EDL76166.1 425 synaptotagmin IV, isoform CRA_a [Rattus norvegicus]
GI:13928964 GenBank ACQ12417.1 425 Sequence 5 from patent US 7507549

Related Sequences to LMP012701 proteins

Reference Database Accession Length Protein Name
GI:13928964 GenBank AAA68519.1 425 synaptotagmin IV homolog [Rattus norvegicus]
GI:13928964 GenBank AAA67327.1 425 synaptotagmin IV [Rattus norvegicus]
GI:13928964 GenBank AAE68292.1 425 Sequence 5 from patent US 6218523