Gene/Proteome Database (LMPD)

LMPD ID
LMP012688
Gene ID
64040
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 9 family, member A1
Gene Symbol
Aldh9a1
Synonyms
Tmaba-dh;
Alternate Names
4-trimethylaminobutyraldehyde dehydrogenase; TMABADH; aldehyde dehydrogenase 9A1; aldehyde dehydrogenase family 9 member A1; aldehyde dehydrogenase family 9, subfamily A1; gamma-trimethylaminobutyraldehyde dehydrogenase;
Chromosome
13
Map Location
13q24
EC Number
1.2.1.47
Summary
catalyzes the conversion of gamma-trimethylaminobutyraldehyde to gamma-butyrobetaine in carnitine biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Aldh9a1

Proteins

4-trimethylaminobutyraldehyde dehydrogenase
Refseq ID NP_071609
Protein GI 75905479
UniProt ID Q9JLJ3
mRNA ID NM_022273
Length 497
MSTGTFVVSQPLNYRGGARVEPVDASGTEKAFEPATGREIATFKCSGEKEVNLAVENAKAAFKIWSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKSIFEARLDVDTSWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCLGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSALLLAEIYTKAGAPNGLFNVVQGGAATGQFLCQHRDVAKVSFTGSVPTGMKIMEMAAKGIKPITLELGGKSPLIIFSDCNMKNAVKGALLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQTQRIKIGDPLLEDTRMGPLINAPHLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMTPCILTNCTDDMTCVKEEIFGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHRVAAELQAGTCYINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESPFENQ
mat_peptide: 2..494 product: 4-trimethylaminobutyraldehyde dehydrogenase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9JLJ3.1) calculated_mol_wt: 53548 peptide sequence: STGTFVVSQPLNYRGGARVEPVDASGTEKAFEPATGREIATFKCSGEKEVNLAVENAKAAFKIWSKKSGLERCQVLLEAARIIKERRDEIAIMETINNGKSIFEARLDVDTSWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCLGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSALLLAEIYTKAGAPNGLFNVVQGGAATGQFLCQHRDVAKVSFTGSVPTGMKIMEMAAKGIKPITLELGGKSPLIIFSDCNMKNAVKGALLANFLTQGQVCCNGTRVFVQKEIADAFTKEVVRQTQRIKIGDPLLEDTRMGPLINAPHLERVLGFVRSAKEQGATVLCGGEPYAPEDPKLKHGYYMTPCILTNCTDDMTCVKEEIFGPVMSILTFETEAEVLERANDTTFGLAAGVFTRDIQRAHRVAAELQAGTCYINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESPF

Gene Information

Entrez Gene ID
64040
Gene Name
aldehyde dehydrogenase 9 family, member A1
Gene Symbol
Aldh9a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0047105 IDA:RGD F 4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0051287 IDA:RGD F NAD binding
GO:0004029 IDA:RGD F aldehyde dehydrogenase (NAD) activity
GO:0043176 IDA:RGD F amine binding
GO:0019145 IDA:RGD F aminobutyraldehyde dehydrogenase activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0045329 TAS:RGD P carnitine biosynthetic process
GO:0006081 IEA:Ensembl P cellular aldehyde metabolic process
GO:0001822 IEP:RGD P kidney development
GO:0001889 IEP:RGD P liver development
GO:0042136 IEA:Ensembl P neurotransmitter biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00330 Arginine and proline metabolism
rno00330 Arginine and proline metabolism
ko00053 Ascorbate and aldarate metabolism
rno00053 Ascorbate and aldarate metabolism
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
M00135 GABA biosynthesis, eukaryotes, putrescine => GABA
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00010 Glycolysis / Gluconeogenesis
rno00010 Glycolysis / Gluconeogenesis
ko00340 Histidine metabolism
rno00340 Histidine metabolism
ko00310 Lysine degradation
rno00310 Lysine degradation
rno01100 Metabolic pathways
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation
ko00410 beta-Alanine metabolism
rno00410 beta-Alanine metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6100 L-carnitine biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953318 Carnitine synthesis
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 9 family, member A1
Protein Entry
AL9A1_RAT
UniProt ID
Q9JLJ3
Species
Rat

Comments

Comment Type Description
Catalytic Activity 4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH.
Catalytic Activity An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Function Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine
Pathway Amine and polyamine biosynthesis; carnitine biosynthesis.
Similarity Belongs to the aldehyde dehydrogenase family
Subcellular Location Cytoplasm.
Subunit Homotetramer

Identical and Related Proteins

Unique RefSeq proteins for LMP012688 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
75905479 RefSeq NP_071609 497 4-trimethylaminobutyraldehyde dehydrogenase

Identical Sequences to LMP012688 proteins

Reference Database Accession Length Protein Name
GI:75905479 GenBank AAH74019.1 497 Aldehyde dehydrogenase 9 family, member A1 [Rattus norvegicus]

Related Sequences to LMP012688 proteins

Reference Database Accession Length Protein Name
GI:75905479 GenBank AAH74019.1 497 Aldehyde dehydrogenase 9 family, member A1 [Rattus norvegicus]
GI:75905479 GenBank EDM09283.1 521 aldehyde dehydrogenase family 9, subfamily A1 [Rattus norvegicus]
GI:75905479 SwissProt Q9JLJ3.1 494 RecName: Full=4-trimethylaminobutyraldehyde dehydrogenase; Short=TMABADH; AltName: Full=Aldehyde dehydrogenase family 9 member A1 [Rattus norvegicus]