Gene/Proteome Database (LMPD)

LMPD ID
LMP012662
Gene ID
58852
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 1, group H, member 3
Gene Symbol
Nr1h3
Synonyms
LXRalpha;
Alternate Names
oxysterols receptor LXR-alpha; RLD-1; liver X receptor alpha; nuclear orphan receptor LXR-alpha;
Chromosome
3
Map Location
3q24
Summary
orphan receptor; involved in the stimulation of CYP7A1 transcription [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr1h3

Proteins

oxysterols receptor LXR-alpha
Refseq ID NP_113815
Protein GI 145279192
UniProt ID Q5I035
mRNA ID NM_031627
Length 445
MSLWLEAAVPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGGALRIGLESSEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRSMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

Gene Information

Entrez Gene ID
58852
Gene Name
nuclear receptor subfamily 1, group H, member 3
Gene Symbol
Nr1h3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0000978 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA:Ensembl F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0004879 IEA:Ensembl F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0044255 IEA:Ensembl P cellular lipid metabolic process
GO:0071222 IEA:Ensembl P cellular response to lipopolysaccharide
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0010887 IEA:Ensembl P negative regulation of cholesterol storage
GO:0050728 IEA:Ensembl P negative regulation of inflammatory response
GO:0043031 IEA:Ensembl P negative regulation of macrophage activation
GO:0090188 IEA:Ensembl P negative regulation of pancreatic juice secretion
GO:0045861 IEA:Ensembl P negative regulation of proteolysis
GO:0090341 IEA:Ensembl P negative regulation of secretion of lysosomal enzymes
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0010875 IEA:Ensembl P positive regulation of cholesterol efflux
GO:2000188 IEA:Ensembl P regulation of cholesterol homeostasis
GO:0070328 IEA:Ensembl P triglyceride homeostasis

KEGG Pathway Links

KEGG Pathway ID Description
ko05160 Hepatitis C
rno05160 Hepatitis C
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR023257 Liver X receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 3
Protein Entry
Q5I035_RAT
UniProt ID
Q5I035
Species
Rat

Comments

Comment Type Description
Similarity Belongs to the nuclear hormone receptor family
Similarity Contains nuclear receptor DNA-binding domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012662 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145279192 RefSeq NP_113815 445 oxysterols receptor LXR-alpha

Identical Sequences to LMP012662 proteins

Reference Database Accession Length Protein Name
GI:145279192 GenBank EDL79514.1 445 nuclear receptor subfamily 1, group H, member 3, isoform CRA_a [Rattus norvegicus]
GI:145279192 RefSeq XP_006234595.1 445 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Rattus norvegicus]
GI:145279192 RefSeq XP_006234596.1 445 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Rattus norvegicus]
GI:145279192 RefSeq XP_006234597.1 445 PREDICTED: oxysterols receptor LXR-alpha isoform X1 [Rattus norvegicus]

Related Sequences to LMP012662 proteins

Reference Database Accession Length Protein Name
GI:145279192 GenBank AAH88750.1 445 Nuclear receptor subfamily 1, group H, member 3 [Rattus norvegicus]
GI:145279192 GenBank EDL79513.1 445 nuclear receptor subfamily 1, group H, member 3, isoform CRA_a [Rattus norvegicus]
GI:145279192 GenBank EDL79514.1 445 nuclear receptor subfamily 1, group H, member 3, isoform CRA_a [Rattus norvegicus]