Gene/Proteome Database (LMPD)

LMPD ID
LMP012661
Gene ID
58851
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
Nr1h2
Synonyms
OR-1;
Alternate Names
oxysterols receptor LXR-beta; UR; ubiquitous receptor; liver X receptor beta; orphan nuclear receptor OR-1; nuclear orphan receptor LXR-beta; ubiquitously-expressed nuclear receptor;
Chromosome
1
Map Location
1q22
Summary
nuclear orphan receptor; may be involved in modulating 9-cis-retinoic acid signaling by interacting with retinoic acid receptor (RXR) [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr1h2

Proteins

oxysterols receptor LXR-beta
Refseq ID NP_113814
Protein GI 13928862
UniProt ID Q62755
mRNA ID NM_031626
Length 443
MSSPTSSLDTPLPGNGSPQPSTSSTSPTIKEEVQETDPPPGSEGSSSAYIVEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKKIQKQQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAVQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

Gene Information

Entrez Gene ID
58851
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
Nr1h2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0000978 IMP:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0004879 IEA:Ensembl F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046965 IDA:RGD F retinoid X receptor binding
GO:0001133 IDA:RGD F sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0044255 IEA:Ensembl P cellular lipid metabolic process
GO:0010887 IEA:Ensembl P negative regulation of cholesterol storage
GO:0010629 IDA:RGD P negative regulation of gene expression
GO:0032369 IEA:Ensembl P negative regulation of lipid transport
GO:0048550 IEA:Ensembl P negative regulation of pinocytosis
GO:0045892 IEA:Ensembl P negative regulation of transcription, DNA-templated
GO:0032270 IEA:Ensembl P positive regulation of cellular protein metabolic process
GO:0010875 IEA:Ensembl P positive regulation of cholesterol efflux
GO:0045723 IEA:Ensembl P positive regulation of fatty acid biosynthetic process
GO:0010628 IDA:RGD P positive regulation of gene expression
GO:0051006 IEA:Ensembl P positive regulation of lipoprotein lipase activity
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0010867 IEA:Ensembl P positive regulation of triglyceride biosynthetic process
GO:2000188 ISS:UniProtKB P regulation of cholesterol homeostasis
GO:0048384 IDA:RGD P retinoic acid receptor signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR023257 Liver X receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 2
Protein Entry
NR1H2_RAT
UniProt ID
Q62755
Species
Rat

Comments

Comment Type Description
Function Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity)
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Forms a heterodimer with RXR.

Identical and Related Proteins

Unique RefSeq proteins for LMP012661 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13928862 RefSeq NP_113814 443 oxysterols receptor LXR-beta

Identical Sequences to LMP012661 proteins

Reference Database Accession Length Protein Name
GI:13928862 GenBank AAA52361.1 443 orphan receptor [Rattus norvegicus]
GI:13928862 GenBank ACN04132.1 443 Sequence 8 from patent US 7482366
GI:13928862 GenBank AEP73956.1 443 Sequence 8 from patent US 8013001
GI:13928862 pat US 443 Sequence 4 from patent US 5639616

Related Sequences to LMP012661 proteins

Reference Database Accession Length Protein Name
GI:13928862 GenBank AAA52361.1 443 orphan receptor [Rattus norvegicus]
GI:13928862 GenBank ACN04132.1 443 Sequence 8 from patent US 7482366
GI:13928862 pat US 443 Sequence 4 from patent US 5639616