Gene/Proteome Database (LMPD)

LMPD ID
LMP012653
Gene ID
54705
Species
Rattus norvegicus (Rat)
Gene Name
pyruvate dehyrogenase phosphatase catalytic subunit 1
Gene Symbol
Pdp1
Synonyms
Ppm2c;
Alternate Names
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; PDP 1; PDPC 1; pyruvate dehydrogenase phosphatase isoenzyme 1; pyruvate dehydrogenase phosphatase catalytic subunit 1; pyruvate dehydrogenase phosphatase, catalytic subunit 1; protein phosphatase 2C, magnesium dependent, catalytic subunit; protein phosphatase 2C, magnesium-dependent, catalytic subunit;
Chromosome
5
Map Location
5q13
Summary
catalytic subunit of the mitochondrial matrix phosphatase; involved in reactivation of the pyruvate dehydrogenase complex [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pdp1

Proteins

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1
Refseq ID NP_001258037
Protein GI 402766703
mRNA ID NM_001271108
Length 563
MCVCPGPRRIGIPVRTSSLPLFSDAMPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2
Refseq ID NP_062245
Protein GI 122427836
UniProt ID A1L1J4
mRNA ID NM_019372
Length 538
MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ
N transit_peptide: 1..71 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (O88483.1) calculated_mol_wt: 8607 peptide sequence: MPAPTQLFFPLVRNCELSRIYGTACYCHHKHLCCSPPYIPQNRLRYTPHPAYATFCRPRENWWQYTQGRRY mat_peptide: 72..538 product: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (O88483.1) calculated_mol_wt: 52592 peptide sequence: ASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPANAPIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAVESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESADIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRAKMSSVFEDQNAATHLIRHAVGNNEFGAVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQEQ

Gene Information

Entrez Gene ID
54705
Gene Name
pyruvate dehyrogenase phosphatase catalytic subunit 1
Gene Symbol
Pdp1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 TAS:RGD C mitochondrial matrix
GO:0005739 IDA:RGD C mitochondrion
GO:0004741 IDA:RGD F [pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0000287 IDA:RGD F magnesium ion binding
GO:0004724 IDA:RGD F magnesium-dependent protein serine/threonine phosphatase activity
GO:0032403 IMP:RGD F protein complex binding
GO:0004722 IMP:RGD F protein serine/threonine phosphatase activity
GO:0043085 IC:RGD P positive regulation of catalytic activity
GO:0006470 IDA:RGD P protein dephosphorylation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953268 Pyruvate metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5954047 Regulation of pyruvate dehydrogenase (PDH) complex
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR015655 Protein phosphatase 2C
IPR001932 Protein phosphatase 2C (PP2C)-like domain
IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site

UniProt Annotations

Entry Information

Gene Name
pyruvate dehyrogenase phosphatase catalytic subunit 1
Species
Rat

Comments

Comment Type Description
Catalytic Activity [Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H(2)O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17532339}; Note=Binds 2 magnesium ions per subunit. {ECO:0000269|PubMed:17532339};
Function Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Similarity Belongs to the PP2C family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit. {ECO:0000269|PubMed:17532339}.
Tissue Specificity Highly expressed in skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012653 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
402766703 RefSeq NP_001258037 563 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1
122427836 RefSeq NP_062245 538 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2

Identical Sequences to LMP012653 proteins

Reference Database Accession Length Protein Name
GI:402766703 GenBank EDL05634.1 563 mCG54027, isoform CRA_a [Mus musculus]
GI:122427836 GenBank EDL05635.1 538 mCG54027, isoform CRA_b [Mus musculus]
GI:402766703 GenBank EDL98444.1 563 protein phosphatase 2C, magnesium dependent, catalytic subunit, isoform CRA_a [Rattus norvegicus]
GI:122427836 GenBank EDL98446.1 538 protein phosphatase 2C, magnesium dependent, catalytic subunit, isoform CRA_c [Rattus norvegicus]
GI:122427836 GenBank AAI38991.1 538 Protein phosphatase 2C, magnesium dependent, catalytic subunit [Mus musculus]
GI:122427836 GenBank AAI38990.1 538 Protein phosphatase 2C, magnesium dependent, catalytic subunit [Mus musculus]
GI:402766703 RefSeq XP_006237971.1 563 PREDICTED: [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform X1 [Rattus norvegicus]
GI:402766703 RefSeq NP_001277320.1 563 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform b [Mus musculus]

Related Sequences to LMP012653 proteins

Reference Database Accession Length Protein Name
GI:402766703 GenBank EDL05634.1 563 mCG54027, isoform CRA_a [Mus musculus]
GI:402766703 GenBank EDL98444.1 563 protein phosphatase 2C, magnesium dependent, catalytic subunit, isoform CRA_a [Rattus norvegicus]
GI:122427836 GenBank EDL98446.1 538 protein phosphatase 2C, magnesium dependent, catalytic subunit, isoform CRA_c [Rattus norvegicus]
GI:122427836 RefSeq NP_001028625.1 538 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform c [Mus musculus]
GI:402766703 RefSeq NP_001091700.1 563 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform b [Mus musculus]
GI:122427836 SwissProt Q3UV70.1 538 RecName: Full=[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Short=PDP 1; AltName: Full=Protein phosphatase 2C; AltName: Full=Pyruvate dehydrogenase phosphatase catalytic subunit 1; Short=PDPC 1; Flags: Precursor [Mus musculus]