Gene/Proteome Database (LMPD)

LMPD ID
LMP012636
Gene ID
29758
Species
Rattus norvegicus (Rat)
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Gene Symbol
St6galnac3
Synonyms
Siat7c;
Alternate Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; STY; SIAT7-C; ST6GalNAcIII; ST6GalNAc III; sialyltransferase 7c; galNAc alpha-2,6-sialyltransferase III; ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) C; sialyltransferase 7 ((alpha-N-acetylneuraminyl 23-betagalactosyl-13)-N-acetyl galactosaminide alpha-26-sialyltransferase) C;
Chromosome
2
Map Location
2q45
EC Number
2.4.99.-
Summary
GalNAc alpha-2,6-sialyltransferase that forms a ganglioside G(D1alpha) from G(M1b). [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for St6galnac3

Proteins

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Refseq ID NP_061996
Protein GI 9507099
UniProt ID Q64686
mRNA ID NM_019123
Length 305
MACILKRKPALAVSFIALCILLLAMRLANDVTFPLLLNCFGQPKTKWIPLSYTLRQPLQTHYGYINVRTQEPLQLNCNHCAVVSNSGQMVGQKVGEEIDRASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASTTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQRMTYCDGVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMINETYCTTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWTVS

Gene Information

Entrez Gene ID
29758
Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Gene Symbol
St6galnac3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008373 IDA:RGD F sialyltransferase activity
GO:0006486 IDA:RGD P protein glycosylation
GO:0097503 IDA:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00604 Glycosphingolipid biosynthesis - ganglio series
rno00604 Glycosphingolipid biosynthesis - ganglio series
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29

UniProt Annotations

Entry Information

Gene Name
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Protein Entry
SIA7C_RAT
UniProt ID
Q64686
Species
Rat

Comments

Comment Type Description
Catalytic Activity CMP-N-acetylneuraminate + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D- galactosaminyl)-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3- beta-D-galactosyl-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D- galactosaminyl)-glycoprotein.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 29 family
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue Specificity Highly expressed in spleen, newborn brain and kidney and to a lesser extent in lung. Not found in liver and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP012636 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9507099 RefSeq NP_061996 305 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Identical Sequences to LMP012636 proteins

Reference Database Accession Length Protein Name
GI:9507099 GenBank AAC42086.1 305 alpha 2,6-sialyltransferase [Rattus norvegicus]
GI:9507099 PRF - 305 GlcNAc alpha2,6-sialyltransferase [Rattus norvegicus]
GI:9507099 SwissProt Q64686.1 305 RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; AltName: Full=GalNAc alpha-2,6-sialyltransferase III; AltName: Full=ST6GalNAc III; Short=ST6GalNAcIII; AltName: Full=STY; AltName: Full=Sialyltransferase 7C; Short=SIAT7-C [Rattus norvegicus]

Related Sequences to LMP012636 proteins

Reference Database Accession Length Protein Name
GI:9507099 GenBank AAC42086.1 305 alpha 2,6-sialyltransferase [Rattus norvegicus]
GI:9507099 PRF - 305 GlcNAc alpha2,6-sialyltransferase [Rattus norvegicus]
GI:9507099 SwissProt Q64686.1 305 RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; AltName: Full=GalNAc alpha-2,6-sialyltransferase III; AltName: Full=ST6GalNAc III; Short=ST6GalNAcIII; AltName: Full=STY; AltName: Full=Sialyltransferase 7C; Short=SIAT7-C [Rattus norvegicus]