Gene/Proteome Database (LMPD)

LMPD ID
LMP012619
Gene ID
29637
Species
Rattus norvegicus (Rat)
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Gene Symbol
Hmgcs1
Alternate Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic; HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 1; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble);
Chromosome
2
Map Location
2q16
EC Number
2.3.3.10
Summary
catalyzes the conversion of (S)-3-hydroxy-3-methylglutaryl-CoA and CoA to acetyl-CoA, acetoacetyl-CoA, and H2O [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hmgcs1

Proteins

hydroxymethylglutaryl-CoA synthase, cytoplasmic
Refseq ID NP_058964
Protein GI 8393538
UniProt ID P17425
mRNA ID NM_017268
Length 520
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERNSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAIYASGNARPTGGVGAVALLIGPNAPVIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPSTNDHSLDEGVGLVHSNTATEHIPSPAKKVPRLPATSGEPESAVISNGEH

Gene Information

Entrez Gene ID
29637
Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Gene Symbol
Hmgcs1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0005634 IEA:Ensembl C nucleus
GO:0005886 IEA:Ensembl C plasma membrane
GO:0008144 IDA:RGD F drug binding
GO:0004421 IDA:RGD F hydroxymethylglutaryl-CoA synthase activity
GO:0016853 IDA:RGD F isomerase activity
GO:0043177 IDA:RGD F organic acid binding
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0007420 IEP:RGD P brain development
GO:0071397 IEP:RGD P cellular response to cholesterol
GO:0071372 IEP:RGD P cellular response to follicle-stimulating hormone stimulus
GO:0071407 IEP:RGD P cellular response to organic cyclic compound
GO:0006695 IEA:UniProtKB-KW P cholesterol biosynthetic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process
GO:0001889 IEP:RGD P liver development
GO:0008584 IEP:RGD P male gonad development
GO:0070723 IEP:RGD P response to cholesterol
GO:0042493 IEP:RGD P response to drug
GO:0034698 IEP:RGD P response to gonadotropin
GO:0009725 IEP:RGD P response to hormone
GO:0055094 IEP:RGD P response to lipoprotein particle
GO:0009645 IEP:RGD P response to low light intensity stimulus
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0010033 IEP:RGD P response to organic substance
GO:0010243 IDA:RGD P response to organonitrogen compound
GO:0014074 IEP:RGD P response to purine-containing compound
GO:0046690 IEP:RGD P response to tellurium ion
GO:0033197 IEP:RGD P response to vitamin E

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
rno01100 Metabolic pathways
ko00072 Synthesis and degradation of ketone bodies
rno00072 Synthesis and degradation of ketone bodies
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953924 Cholesterol biosynthesis
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954333 PPARA activates gene expression
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Domain Information

InterPro Annotations

Accession Description
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Protein Entry
HMCS1_RAT
UniProt ID
P17425
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Similarity Belongs to the HMG-CoA synthase family
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP012619 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393538 RefSeq NP_058964 520 hydroxymethylglutaryl-CoA synthase, cytoplasmic

Identical Sequences to LMP012619 proteins

Reference Database Accession Length Protein Name
GI:8393538 GenBank EDM10425.1 520 rCG44679, isoform CRA_a [Rattus norvegicus]
GI:8393538 GenBank EDM10426.1 520 rCG44679, isoform CRA_a [Rattus norvegicus]
GI:8393538 pat US 520 Sequence 5 from patent US 5668001
GI:8393538 RefSeq XP_006232021.1 520 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [Rattus norvegicus]

Related Sequences to LMP012619 proteins

Reference Database Accession Length Protein Name
GI:8393538 EMBL CAA36852.1 520 cytosolic 3-hydroxy 3-methylglutaryl coenzyme A synthase [Rattus norvegicus]
GI:8393538 GenBank EDM10426.1 520 rCG44679, isoform CRA_a [Rattus norvegicus]
GI:8393538 SwissProt P17425.1 520 RecName: Full=Hydroxymethylglutaryl-CoA synthase, cytoplasmic; Short=HMG-CoA synthase; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase [Rattus norvegicus]