Gene/Proteome Database (LMPD)

LMPD ID
LMP012615
Gene ID
29603
Species
Rattus norvegicus (Rat)
Gene Name
branched chain ketoacid dehydrogenase kinase
Gene Symbol
Bckdk
Alternate Names
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; BCKDHKIN; BCKD-kinase; branched-chain alpha-ketoacid dehydrogenase kinase;
Chromosome
1
Map Location
1q36
EC Number
2.7.11.4
Summary
mitochondrial kinase; involved in oxidative degradation of branched-chain amino acids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Bckdk

Proteins

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor
Refseq ID NP_062117
Protein GI 158517950
UniProt ID Q00972
mRNA ID NM_019244
Length 412
MILTSVLGSGPRSGSSLWPLLGSSLSLRVRSTSATDTHHVELARERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI
transit_peptide: 1..30 experiment: experimental evidence, no additional details recorded note: Mitochondrion; propagated from UniProtKB/Swiss-Prot (Q00972.2) calculated_mol_wt: 3128 peptide sequence: MILTSVLGSGPRSGSSLWPLLGSSLSLRVR mat_peptide: 31..412 product: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q00972.2) calculated_mol_wt: 43365 peptide sequence: STSATDTHHVELARERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRIAHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLDDHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGIGTDVYLRLRHIDGREESFRI

Gene Information

Entrez Gene ID
29603
Gene Name
branched chain ketoacid dehydrogenase kinase
Gene Symbol
Bckdk
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005947 IDA:HGNC C mitochondrial alpha-ketoglutarate dehydrogenase complex
GO:0005739 TAS:RGD C mitochondrion
GO:0005524 IDA:HGNC F ATP binding
GO:0047323 IMP:RGD F [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
GO:0004674 IDA:HGNC F protein serine/threonine kinase activity
GO:0009083 IDA:HGNC P branched-chain amino acid catabolic process
GO:0016310 IDA:HGNC P phosphorylation
GO:0006468 IDA:GOC P protein phosphorylation

Domain Information

InterPro Annotations

Accession Description
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR005467 Signal transduction histidine kinase, core
IPR004358 Signal transduction histidine kinase-related protein, C-terminal

UniProt Annotations

Entry Information

Gene Name
branched chain ketoacid dehydrogenase kinase
Protein Entry
BCKD_RAT
UniProt ID
Q00972
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] = ADP + [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] phosphate.
Function Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
Ptm Autophosphorylated.
Similarity Belongs to the PDK/BCKDK protein kinase family
Similarity Contains 1 histidine kinase domain
Subcellular Location Mitochondrion matrix.
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012615 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158517950 RefSeq NP_062117 412 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial precursor

Identical Sequences to LMP012615 proteins

Reference Database Accession Length Protein Name
GI:158517950 GenBank EDM17216.1 412 rCG39586, isoform CRA_a [Rattus norvegicus]
GI:158517950 GenBank EDM17217.1 412 rCG39586, isoform CRA_a [Rattus norvegicus]
GI:158517950 SwissProt Q00972.2 412 RecName: Full=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; AltName: Full=Branched-chain alpha-ketoacid dehydrogenase kinase; Short=BCKD-kinase; Short=BCKDHKIN; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012615 proteins

Reference Database Accession Length Protein Name
GI:158517950 GenBank EDM17216.1 412 rCG39586, isoform CRA_a [Rattus norvegicus]
GI:158517950 GenBank EDM17217.1 412 rCG39586, isoform CRA_a [Rattus norvegicus]
GI:158517950 SwissProt Q00972.2 412 RecName: Full=[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; AltName: Full=Branched-chain alpha-ketoacid dehydrogenase kinase; Short=BCKD-kinase; Short=BCKDHKIN; Flags: Precursor [Rattus norvegicus]