Gene/Proteome Database (LMPD)

LMPD ID
LMP012592
Gene ID
29441
Species
Rattus norvegicus (Rat)
Gene Name
P450 (cytochrome) oxidoreductase
Gene Symbol
Por
Synonyms
CYPOR;
Alternate Names
NADPH--cytochrome P450 reductase; CPR; P450R; cytochrome P450 reductase;
Chromosome
12
Map Location
12q12
EC Number
1.6.2.4;
Summary
plays a role in electron transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Por

Proteins

NADPH--cytochrome P450 reductase
Refseq ID NP_113764
Protein GI 13928780
UniProt ID P00388
mRNA ID NM_031576
Length 678
MGDSHEDTSATMPEAVAEEVSLFSTTDMVLFSLIVGVLTYWFIFRKKKEEIPEFSKIQTTAPPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATGEESSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGENGGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS

Gene Information

Entrez Gene ID
29441
Gene Name
P450 (cytochrome) oxidoreductase
Gene Symbol
Por
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IBA:RefGenome C cytosol
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0016020 IDA:RGD C membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0010181 IMP:RGD F FMN binding
GO:0050661 IDA:RGD F NADP binding
GO:0003958 IDA:BHF-UCL F NADPH-hemoprotein reductase activity
GO:0004128 IDA:RGD F cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0009055 IDA:RGD F electron carrier activity
GO:0019899 IPI:BHF-UCL F enzyme binding
GO:0050660 IMP:RGD F flavin adenine dinucleotide binding
GO:0016787 IDA:RGD F hydrolase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0047726 IDA:RGD F iron-cytochrome-c reductase activity
GO:0008941 IDA:RGD F nitric oxide dioxygenase activity
GO:0016709 IBA:RefGenome F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0009437 IEP:RGD P carnitine metabolic process
GO:0090346 IEA:Ensembl P cellular organofluorine metabolic process
GO:0071372 IEP:RGD P cellular response to follicle-stimulating hormone stimulus
GO:0071371 IEP:RGD P cellular response to gonadotropin stimulus
GO:0071375 IEP:RGD P cellular response to peptide hormone stimulus
GO:0070988 IDA:RGD P demethylation
GO:0019395 IDA:RGD P fatty acid oxidation
GO:0009812 IEP:RGD P flavonoid metabolic process
GO:0018393 IDA:RGD P internal peptidyl-lysine acetylation
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0043154 IMP:RGD P negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0060192 IDA:RGD P negative regulation of lipase activity
GO:0043602 IDA:RGD P nitrate catabolic process
GO:0046210 IDA:RGD P nitric oxide catabolic process
GO:0055114 IDA:BHF-UCL P oxidation-reduction process
GO:0045542 IMP:RGD P positive regulation of cholesterol biosynthetic process
GO:0032332 IMP:RGD P positive regulation of chondrocyte differentiation
GO:0032770 IEA:Ensembl P positive regulation of monooxygenase activity
GO:0045880 IMP:RGD P positive regulation of smoothened signaling pathway
GO:0090031 IDA:RGD P positive regulation of steroid hormone biosynthetic process
GO:0090181 IMP:RGD P regulation of cholesterol metabolic process
GO:0003420 IMP:RGD P regulation of growth plate cartilage chondrocyte proliferation
GO:0042493 IEP:RGD P response to drug
GO:0007584 IEP:RGD P response to nutrient

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6061 bile acid biosynthesis, neutral pathway

Domain Information

InterPro Annotations

Accession Description
IPR003097 FAD-binding, type 1
IPR017927 Ferredoxin reductase-type FAD-binding domain
IPR001094 Flavodoxin
IPR008254 Flavodoxin/nitric oxide synthase
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR029039 Flavoprotein-like
IPR023208 NADPH-cytochrome P450 reductase
IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR017938 Riboflavin synthase-like beta-barrel

UniProt Annotations

Entry Information

Gene Name
P450 (cytochrome) oxidoreductase
Protein Entry
NCPR_RAT
UniProt ID
P00388
Species
Rat

Comments

Comment Type Description
Catalytic Activity NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Cofactor Name=FMN; Xref=ChEBI:CHEBI:58210;
Function This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
Similarity Contains 1 FAD-binding FR-type domain
Similarity Contains 1 flavodoxin-like domain
Similarity In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Anchored to the ER membrane by its N- terminal hydrophobic region.

Identical and Related Proteins

Unique RefSeq proteins for LMP012592 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13928780 RefSeq NP_113764 678 NADPH--cytochrome P450 reductase

Identical Sequences to LMP012592 proteins

Reference Database Accession Length Protein Name
GI:13928780 GenBank AAA41067.1 678 NADPH-cytochrome P-450 reductase [Rattus norvegicus]
GI:13928780 GenBank ABH71439.1 678 Sequence 54 from patent US 7033807
GI:13928780 GenBank EDM13360.1 678 P450 (cytochrome) oxidoreductase, isoform CRA_a [Rattus norvegicus]
GI:13928780 GenBank EDM13361.1 678 P450 (cytochrome) oxidoreductase, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012592 proteins

Reference Database Accession Length Protein Name
GI:13928780 GenBank AAA41064.1 678 NADPH:ferricytochrome oxidoreductase (EC 1.6.2.4) [Rattus norvegicus]
GI:13928780 GenBank AAA41067.1 678 NADPH-cytochrome P-450 reductase [Rattus norvegicus]
GI:13928780 SwissProt P00388.3 678 RecName: Full=NADPH--cytochrome P450 reductase; Short=CPR; Short=P450R [Rattus norvegicus]