Gene/Proteome Database (LMPD)

LMPD ID
LMP012586
Gene ID
29387
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group IIC
Gene Symbol
Pla2g2c
Alternate Names
group IIC secretory phospholipase A2; PLA2-8; sPLA2-IIC; GIIC sPLA2; 14 kDa phospholipase A2; phospholipase A2, group 2C; phosphatidylcholine 2-acylhydrolase 2C; phosphatidylcholine 2-acylhydrolase GIIC;
Chromosome
5
Map Location
5q36
Summary
catalyzes Ca+2 dependent hydrolysis of phospholipids including hydrolysis of L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pla2g2c

Proteins

group IIC secretory phospholipase A2
Refseq ID NP_062075
Protein GI 9506977
UniProt ID Q4V8L7
mRNA ID NM_019202
Length 158
MDLLVSSGMKGIAVFLVFIFCWTTSTLSSFWQFQRMVKHITGRSAFFSYYGYGCYCGLGGRGIPVDATDRCCWAHDCCYHKLKEYGCQPILNAYQFAIVNGTVTCGCTMGGGCLCGQKACECDKLSVYCFKENLATYEKTFKQLFPTRPQCGRDKLHC

Gene Information

Entrez Gene ID
29387
Gene Name
phospholipase A2, group IIC
Gene Symbol
Pla2g2c
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 IEA:InterPro F phospholipase A2 activity
GO:0016042 IEA:InterPro P lipid catabolic process
GO:0006644 IEA:InterPro P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko00591 Linoleic acid metabolism
rno00591 Linoleic acid metabolism
rno01100 Metabolic pathways
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
rno04014 Ras signaling pathway
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001211 Phospholipase A2
IPR016090 Phospholipase A2 domain
IPR013090 Phospholipase A2, active site

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IIC
Protein Entry
Q4V8L7_RAT
UniProt ID
Q4V8L7
Species
Rat

Comments

Comment Type Description
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate
Cofactor Note=Binds 1 calcium ion per subunit. ;
Similarity Belongs to the phospholipase A2 family
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP012586 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
9506977 RefSeq NP_062075 158 group IIC secretory phospholipase A2

Identical Sequences to LMP012586 proteins

Reference Database Accession Length Protein Name
GI:9506977 RefSeq XP_006239205.1 158 PREDICTED: group IIC secretory phospholipase A2 isoform X1 [Rattus norvegicus]
GI:9506977 RefSeq XP_008762434.1 158 PREDICTED: group IIC secretory phospholipase A2 isoform X1 [Rattus norvegicus]
GI:9506977 RefSeq XP_008762435.1 158 PREDICTED: group IIC secretory phospholipase A2 isoform X1 [Rattus norvegicus]
GI:9506977 RefSeq XP_008762436.1 158 PREDICTED: group IIC secretory phospholipase A2 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012586 proteins

Reference Database Accession Length Protein Name
GI:9506977 GenBank AAE33224.1 158 Sequence 22 from patent US 5972677
GI:9506977 GenBank AAE95391.1 158 Sequence 22 from patent US 6352849
GI:9506977 RefSeq XP_008762434.1 158 PREDICTED: group IIC secretory phospholipase A2 isoform X1 [Rattus norvegicus]