Gene/Proteome Database (LMPD)

LMPD ID
LMP012585
Gene ID
29367
Species
Rattus norvegicus (Rat)
Gene Name
choline kinase beta
Gene Symbol
Chkb
Synonyms
Chkl; Chetk;
Alternate Names
choline/ethanolamine kinase; CK; EK; CKB; CKEKB; ethanolamine kinase; choline/ethanolamine kinase beta;
Chromosome
7
Map Location
7q34
EC Number
2.7.1.32
Summary
choline/ethanolamine kinase enzyme [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Chkb

Proteins

choline/ethanolamine kinase
Refseq ID NP_058873
Protein GI 8393104
UniProt ID O54783
mRNA ID NM_017177
Length 394
MAADGTGVVGGGAVGGPLSKDGLLDAKCPEPIPNRRRSSSLSRDAQRRAYQWCREYLGGAWRRARPEELSVCPVSGGLSNLLFRCSLPNHVPSMGGEPREVLLRLYGAILQGVDSLVLESVMFAILAERSLGPQLYGVFPEGRLEQYLPSRPLKTQELRDPVLSGAIATKMARFHGMEMPFTKEPRWLFGTMERYLKQIQDLPSTSLPQMNLVEMYSLKDEMNHLRTLLDATPSPVVFCHNDIQEGNILLLSEPDSDDNLMLVDFEYSSYNYRGFDIGNHFCEWVYDYTYEEWPFYKARPADYPTREQQLLFIRHYLAEVQKGEVLSEEEQKKQEEDLLIEISRYALASHFFWGLWSTLQASMSTIEFGYLEYAQSRFQFYFQQKGQLTSFLSP

Gene Information

Entrez Gene ID
29367
Gene Name
choline kinase beta
Gene Symbol
Chkb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004103 ISS:UniProtKB F choline kinase activity
GO:0004305 IEA:UniProtKB-EC F ethanolamine kinase activity
GO:0006657 IDA:GOC P CDP-choline pathway
GO:0007517 IEA:Ensembl P muscle organ development
GO:0006646 ISS:UniProtKB P phosphatidylethanolamine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954091 Synthesis of PC
5954474 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
choline kinase beta
Protein Entry
CHKB_RAT
UniProt ID
O54783
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + choline = ADP + phosphocholine.
Catalytic Activity ATP + ethanolamine = ADP + O- phosphoethanolamine.
Function Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis (By similarity)
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Similarity Belongs to the choline/ethanolamine kinase family
Subunit Homodimer, and heterodimer with CHKA

Identical and Related Proteins

Unique RefSeq proteins for LMP012585 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8393104 RefSeq NP_058873 394 choline/ethanolamine kinase

Identical Sequences to LMP012585 proteins

Reference Database Accession Length Protein Name
GI:8393104 DBBJ BAA24366.1 394 choline/ethanolamine kinase [Rattus norvegicus]
GI:8393104 GenBank AAH60515.1 394 Choline kinase beta [Rattus norvegicus]
GI:8393104 GenBank EDL76571.1 394 choline kinase beta, isoform CRA_a [Rattus norvegicus]
GI:8393104 SwissProt O54783.3 394 RecName: Full=Choline/ethanolamine kinase; AltName: Full=Choline kinase beta; Short=CK; Short=CKB; AltName: Full=Ethanolamine kinase; Short=EK; AltName: Full=choline/ethanolamine kinase beta; Short=CKEKB [Rattus norvegicus]

Related Sequences to LMP012585 proteins

Reference Database Accession Length Protein Name
GI:8393104 DBBJ BAA24366.1 394 choline/ethanolamine kinase [Rattus norvegicus]
GI:8393104 GenBank AAH60515.1 394 Choline kinase beta [Rattus norvegicus]
GI:8393104 SwissProt O54783.3 394 RecName: Full=Choline/ethanolamine kinase; AltName: Full=Choline kinase beta; Short=CK; Short=CKB; AltName: Full=Ethanolamine kinase; Short=EK; AltName: Full=choline/ethanolamine kinase beta; Short=CKEKB [Rattus norvegicus]