Gene/Proteome Database (LMPD)
LMPD ID
LMP012584
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A2, group X
Gene Symbol
Synonyms
PLA2GX; sPLA2-X;
Alternate Names
group 10 secretory phospholipase A2; GX sPLA2; group X phospholipase A2; phospholipase A2, group 10; group X secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 10; phosphatidylcholine 2-acylhydrolase GX;
Chromosome
10
Map Location
10q11
EC Number
3.1.1.4
Summary
mouse homolog has phospholipase A2 activity [RGD, Feb 2006]
Orthologs
Proteins
| group 10 secretory phospholipase A2 precursor | |
|---|---|
| Refseq ID | NP_058872 |
| Protein GI | 8393971 |
| UniProt ID | Q9QZT3 |
| mRNA ID | NM_017176 |
| Length | 151 |
| MLLLLLLLLLGPGSCLSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYYHDCCYSQAQDAGCSPKLYRYPWKCMDHRILCGPAENKCQELLCRCDETLAYCLADTEYHLKYLFFPSVLCEKDSPKCN | |
| sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1769 peptide sequence: MLLLLLLLLLGPGSCLS mat_peptide: 29..151 product: Group 10 secretory phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9QZT3.1) calculated_mol_wt: 13952 peptide sequence: GLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPRDAIDWCCYYHDCCYSQAQDAGCSPKLYRYPWKCMDHRILCGPAENKCQELLCRCDETLAYCLADTEYHLKYLFFPSVLCEKDSPKCN | |
Gene Information
Entrez Gene ID
Gene Name
phospholipase A2, group X
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | TAS:RGD | C | extracellular region |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004623 | IDA:RGD | F | phospholipase A2 activity |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0006644 | IEA:InterPro | P | phospholipid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00590 | Arachidonic acid metabolism |
| rno00590 | Arachidonic acid metabolism |
| ko00565 | Ether lipid metabolism |
| rno00565 | Ether lipid metabolism |
| ko04975 | Fat digestion and absorption |
| rno04975 | Fat digestion and absorption |
| ko00564 | Glycerophospholipid metabolism |
| rno00564 | Glycerophospholipid metabolism |
| ko00591 | Linoleic acid metabolism |
| rno00591 | Linoleic acid metabolism |
| rno01100 | Metabolic pathways |
| ko04972 | Pancreatic secretion |
| rno04972 | Pancreatic secretion |
| rno04014 | Ras signaling pathway |
| ko04270 | Vascular smooth muscle contraction |
| rno04270 | Vascular smooth muscle contraction |
| ko00592 | alpha-Linolenic acid metabolism |
| rno00592 | alpha-Linolenic acid metabolism |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035, ECO:0000255|PROSITE-ProRule:PRU10036}. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ; |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids (By similarity) |
| Similarity | Belongs to the phospholipase A2 family |
| Subcellular Location | Secreted. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012584 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 8393971 | RefSeq | NP_058872 | 151 | group 10 secretory phospholipase A2 precursor |
Identical Sequences to LMP012584 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:8393971 | GenBank | AEU43300.1 | 151 | Sequence 49 from patent US 8052970 |
| GI:8393971 | GenBank | AEU43336.1 | 151 | Sequence 85 from patent US 8052970 |
| GI:8393971 | GenBank | AGO77664.1 | 151 | Sequence 22 from patent US 8399204 |
| GI:8393971 | SwissProt | Q9QZT3.1 | 151 | RecName: Full=Group 10 secretory phospholipase A2; AltName: Full=Group X secretory phospholipase A2; Short=GX sPLA2; Short=sPLA2-X; AltName: Full=Phosphatidylcholine 2-acylhydrolase 10; Flags: Precursor [Rattus norvegicus] |
Related Sequences to LMP012584 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:8393971 | GenBank | AEU43300.1 | 151 | Sequence 49 from patent US 8052970 |
| GI:8393971 | GenBank | AEU43336.1 | 151 | Sequence 85 from patent US 8052970 |
| GI:8393971 | GenBank | AGO77664.1 | 151 | Sequence 22 from patent US 8399204 |