Gene/Proteome Database (LMPD)

LMPD ID
LMP012559
Gene ID
25757
Species
Rattus norvegicus (Rat)
Gene Name
carnitine palmitoyltransferase 1a, liver
Gene Symbol
Cpt1a
Synonyms
CPT-Ia;
Alternate Names
carnitine O-palmitoyltransferase 1, liver isoform; CPT I; CPT1-L; CPTI-L; carnitine palmitoyltransferase 1, liver; carnitine O-palmitoyltransferase I, liver isoform; Carnitine palmitoyltransferase 1 alpha, liver isoform;
Chromosome
1
Map Location
1q43
EC Number
2.3.1.21
Summary
enzyme that catalyses the transfer of long chain fatty acids to carnitine for translocation across the mitochondrial inner membrane [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cpt1a

Proteins

carnitine O-palmitoyltransferase 1, liver isoform
Refseq ID NP_113747
Protein GI 162287173
UniProt ID P32198
mRNA ID NM_031559
Length 773
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK

Gene Information

Entrez Gene ID
25757
Gene Name
carnitine palmitoyltransferase 1a, liver
Gene Symbol
Cpt1a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IDA:RGD C integral component of membrane
GO:0031307 IDA:UniProtKB C integral component of mitochondrial outer membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005743 IEA:Ensembl C mitochondrial inner membrane
GO:0005741 IDA:RGD C mitochondrial outer membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0004095 IDA:UniProtKB F carnitine O-palmitoyltransferase activity
GO:0042802 IDA:RGD F identical protein binding
GO:0009437 IDA:UniProtKB P carnitine metabolic process
GO:0071398 IEP:RGD P cellular response to fatty acid
GO:0042755 IMP:RGD P eating behavior
GO:0030855 IEA:Ensembl P epithelial cell differentiation
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation
GO:0006006 IMP:RGD P glucose metabolic process
GO:0001676 IDA:UniProtKB P long-chain fatty acid metabolic process
GO:0032000 IMP:RGD P positive regulation of fatty acid beta-oxidation
GO:0051260 IDA:RGD P protein homooligomerization
GO:0031998 TAS:RGD P regulation of fatty acid beta-oxidation
GO:0046320 IMP:RGD P regulation of fatty acid oxidation
GO:0050796 IMP:RGD P regulation of insulin secretion
GO:0042493 IEP:RGD P response to drug
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0006810 IEA:UniProtKB-KW P transport
GO:0006641 IMP:RGD P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6111 mitochondrial L-carnitine shuttle

REACTOME Pathway Links

REACTOME Pathway ID Description
5954223 Circadian Clock
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953467 Import of palmitoyl-CoA into the mitochondrial matrix
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954333 PPARA activates gene expression
5954225 RORA activates circadian gene expression
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine palmitoyltransferase 1a, liver
Protein Entry
CPT1A_RAT
UniProt ID
P32198
Species
Rat

Comments

Comment Type Description
Catalytic Activity Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine. {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:21990363}.
Domain A conformation change in the N-terminal region spanning the first 42 residues plays an important role in the regulation of enzyme activity by malonyl-CoA
Enzyme Regulation Inhibited by malonyl-CoA
Function Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism
Pathway Lipid metabolism; fatty acid beta-oxidation.
Similarity Belongs to the carnitine/choline acetyltransferase family
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:19136561, ECO:0000269|PubMed:21622568}; Multi-pass membrane protein {ECO:0000269|PubMed:16908527, ECO:0000269|PubMed:19136561, ECO:0000269|PubMed:21622568}.
Subunit Homohexamer and homotrimer. Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1. Also identified in complexes with ACSL1 and VDAC2 and VDAC3
Tissue Specificity Liver and kidney.

Identical and Related Proteins

Unique RefSeq proteins for LMP012559 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
162287173 RefSeq NP_113747 773 carnitine O-palmitoyltransferase 1, liver isoform

Identical Sequences to LMP012559 proteins

Reference Database Accession Length Protein Name
GI:162287173 GenBank EDM12284.1 773 carnitine palmitoyltransferase 1a, liver, isoform CRA_a [Rattus norvegicus]
GI:162287173 GenBank EDM12285.1 773 carnitine palmitoyltransferase 1a, liver, isoform CRA_a [Rattus norvegicus]
GI:162287173 RefSeq XP_006230757.1 773 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Rattus norvegicus]
GI:162287173 SwissProt P32198.2 773 RecName: Full=Carnitine O-palmitoyltransferase 1, liver isoform; Short=CPT1-L; AltName: Full=Carnitine O-palmitoyltransferase I, liver isoform; Short=CPT I; Short=CPTI-L; AltName: Full=Carnitine palmitoyltransferase 1A [Rattus norvegicus]

Related Sequences to LMP012559 proteins

Reference Database Accession Length Protein Name
GI:162287173 GenBank AAH72522.1 773 Carnitine palmitoyltransferase 1a, liver [Rattus norvegicus]
GI:162287173 RefSeq XP_006230757.1 773 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Rattus norvegicus]
GI:162287173 SwissProt P32198.2 773 RecName: Full=Carnitine O-palmitoyltransferase 1, liver isoform; Short=CPT1-L; AltName: Full=Carnitine O-palmitoyltransferase I, liver isoform; Short=CPT I; Short=CPTI-L; AltName: Full=Carnitine palmitoyltransferase 1A [Rattus norvegicus]