Gene/Proteome Database (LMPD)

LMPD ID
LMP012546
Gene ID
25680
Species
Rattus norvegicus (Rat)
Gene Name
colipase, pancreatic
Gene Symbol
Clps
Synonyms
COLQ;
Alternate Names
colipase;
Chromosome
20
Map Location
20p12
Summary
restores activity to pancreatic lipase after enzyme inhbition by bile salts [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Clps

Proteins

colipase precursor
Refseq ID NP_037271
Protein GI 6978665
UniProt ID P17084
mRNA ID NM_013139
Length 112
MKVLVVLLVTLVAVAYAAPGPRGLFINLEDGEICVNSMQCKSRCCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGVCLDSTRSKQ
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1802 peptide sequence: MKVLVVLLVTLVAVAYA mat_peptide: 23..112 product: Colipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P17084.2) calculated_mol_wt: 9989 peptide sequence: GLFINLEDGEICVNSMQCKSRCCQHDTILGIARCTHKAMENSECSPKTLYGIYYRCPCERGLTCEGDRSIIGAITNTNYGVCLDSTRSKQ

Gene Information

Entrez Gene ID
25680
Gene Name
colipase, pancreatic
Gene Symbol
Clps
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0008047 IDA:RGD F enzyme activator activity
GO:0007586 IEA:UniProtKB-KW P digestion
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0043085 IDA:RGD P positive regulation of catalytic activity
GO:0009791 IEP:RGD P post-embryonic development
GO:0032094 IEP:RGD P response to food

KEGG Pathway Links

KEGG Pathway ID Description
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR001981 Colipase
IPR017914 Colipase, C-terminal
IPR017913 Colipase, N-terminal
IPR017915 Colipase, conserved site

UniProt Annotations

Entry Information

Gene Name
colipase, pancreatic
Protein Entry
COL_RAT
UniProt ID
P17084
Species
Rat

Comments

Comment Type Description
Function Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Function Enterostatin has a biological activity as a satiety signal
Similarity Belongs to the colipase family. {ECO:0000255|PROSITE- ProRule:PRU00674}.
Subcellular Location Secreted.
Subunit Forms a 1:1 stoichiometric complex with pancreatic lipase
Tissue Specificity Expressed by the pancreas.

Identical and Related Proteins

Unique RefSeq proteins for LMP012546 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978665 RefSeq NP_037271 112 colipase precursor

Identical Sequences to LMP012546 proteins

Reference Database Accession Length Protein Name
GI:6978665 GenBank AAA20505.1 112 colipase [Rattus norvegicus]
GI:6978665 SwissProt P17084.2 112 RecName: Full=Colipase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012546 proteins

Reference Database Accession Length Protein Name
GI:6978665 GenBank AAA40943.1 112 colipase [Rattus norvegicus]
GI:6978665 GenBank AAA20505.1 112 colipase [Rattus norvegicus]
GI:6978665 SwissProt P17084.2 112 RecName: Full=Colipase; Flags: Precursor [Rattus norvegicus]