Gene/Proteome Database (LMPD)
LMPD ID
LMP012545
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
inositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol
Synonyms
IP3R3; IP3R3X;
Alternate Names
inositol 1,4,5-trisphosphate receptor type 3; IP3R 3; IP3R-3; insP3R3; IP3 receptor; type 3 InsP3 receptor; inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; type 3 inositol 1,4,5-trisphosphate receptor;
Chromosome
20
Map Location
20p12
Summary
receptor for Inositol 1,4,5-trisphosphate (IP3); involved in second messenger signaling [RGD, Feb 2006]
Orthologs
Proteins
| inositol 1,4,5-trisphosphate receptor type 3 | |
|---|---|
| Refseq ID | NP_037270 |
| Protein GI | 6981110 |
| UniProt ID | Q63269 |
| mRNA ID | NM_013138 |
| Length | 2670 |
| MNEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNVGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYRGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDVSDPKAAGPGAQSRTGRRNAGEKIKYRLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMRDENILKQIFGILKAPFRDKGGEGPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFASTMEFVEDYLNNVVGEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCIQAPAAVLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPTGVGVPEQLDRSKFEDNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSSTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSVKGEEGEAGASKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKNDNKMMEILRYTHQFLQKFCAGNPGNQALLHKHLQLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHCWPTHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCSAAAQRSAANYKTATRTFPRVIPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDMLHWPELLFLEGSEAYQRCESGGFLSKLIRHTKGLMESEEKLCVKVLRTLQQMLQKKSKYGDRGNQLRKMLLQNYLQNRKSGPRGELTDPTGSGVDQDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQETKSTVAVNMSDLGSQPREDREPADPTTKGRVSSFSMPSSSRYSLGPGLHRGHDVSERAQNNEMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKHYSVRPLIVALVLRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPGNHSRASTLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFVDVQNCMSR | |
Gene Information
Entrez Gene ID
Gene Name
inositol 1,4,5-trisphosphate receptor, type 3
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0045177 | IDA:BHF-UCL | C | apical part of cell |
| GO:0005903 | IDA:BHF-UCL | C | brush border |
| GO:0005737 | IDA:RGD | C | cytoplasm |
| GO:0030425 | IDA:RGD | C | dendrite |
| GO:0005783 | IDA:BHF-UCL | C | endoplasmic reticulum |
| GO:0005789 | IDA:RGD | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0043209 | IDA:RGD | C | myelin sheath |
| GO:0043025 | IDA:RGD | C | neuronal cell body |
| GO:0005635 | IDA:RGD | C | nuclear envelope |
| GO:0005640 | IDA:RGD | C | nuclear outer membrane |
| GO:0048471 | IDA:RGD | C | perinuclear region of cytoplasm |
| GO:0005509 | IDA:RGD | F | calcium ion binding |
| GO:0015085 | TAS:RGD | F | calcium ion transmembrane transporter activity |
| GO:0043533 | IDA:RGD | F | inositol 1,3,4,5 tetrakisphosphate binding |
| GO:0070679 | IDA:RGD | F | inositol 1,4,5 trisphosphate binding |
| GO:0005220 | ISS:UniProtKB | F | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| GO:0000822 | IDA:RGD | F | inositol hexakisphosphate binding |
| GO:0005218 | ISS:UniProtKB | F | intracellular ligand-gated calcium channel activity |
| GO:0007186 | IDA:RGD | P | G-protein coupled receptor signaling pathway |
| GO:0060402 | ISS:UniProtKB | P | calcium ion transport into cytosol |
| GO:0071320 | IDA:RGD | P | cellular response to cAMP |
| GO:0048016 | IDA:GOC | P | inositol phosphate-mediated signaling |
| GO:0007204 | IDA:RGD | P | positive regulation of cytosolic calcium ion concentration |
| GO:0051291 | IDA:RGD | P | protein heterooligomerization |
| GO:0051260 | IDA:RGD | P | protein homooligomerization |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko05010 | Alzheimer's disease |
| rno05010 | Alzheimer's disease |
| ko04020 | Calcium signaling pathway |
| rno04020 | Calcium signaling pathway |
| rno04725 | Cholinergic synapse |
| ko04713 | Circadian entrainment |
| rno04713 | Circadian entrainment |
| ko04728 | Dopaminergic synapse |
| rno04728 | Dopaminergic synapse |
| ko04915 | Estrogen signaling pathway |
| rno04915 | Estrogen signaling pathway |
| ko04540 | Gap junction |
| rno04540 | Gap junction |
| ko04971 | Gastric acid secretion |
| rno04971 | Gastric acid secretion |
| ko04724 | Glutamatergic synapse |
| rno04724 | Glutamatergic synapse |
| ko04912 | GnRH signaling pathway |
| rno04912 | GnRH signaling pathway |
| ko04750 | Inflammatory mediator regulation of TRP channels |
| rno04750 | Inflammatory mediator regulation of TRP channels |
| rno04911 | Insulin secretion |
| ko04730 | Long-term depression |
| rno04730 | Long-term depression |
| ko04720 | Long-term potentiation |
| rno04720 | Long-term potentiation |
| ko04114 | Oocyte meiosis |
| rno04114 | Oocyte meiosis |
| ko04921 | Oxytocin signaling pathway |
| rno04921 | Oxytocin signaling pathway |
| ko04972 | Pancreatic secretion |
| rno04972 | Pancreatic secretion |
| ko04070 | Phosphatidylinositol signaling system |
| rno04070 | Phosphatidylinositol signaling system |
| rno04611 | Platelet activation |
| ko05205 | Proteoglycans in cancer |
| rno05205 | Proteoglycans in cancer |
| ko04723 | Retrograde endocannabinoid signaling |
| rno04723 | Retrograde endocannabinoid signaling |
| ko04970 | Salivary secretion |
| rno04970 | Salivary secretion |
| rno04726 | Serotonergic synapse |
| ko04742 | Taste transduction |
| rno04742 | Taste transduction |
| ko04918 | Thyroid hormone synthesis |
| rno04918 | Thyroid hormone synthesis |
| ko04270 | Vascular smooth muscle contraction |
| rno04270 | Vascular smooth muscle contraction |
| ko04022 | cGMP-PKG signaling pathway |
| rno04022 | cGMP-PKG signaling pathway |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000493 | Inositol 1,4,5-trisphosphate-binding protein receptor |
| IPR014821 | Inositol 1,4,5-trisphosphate/ryanodine receptor |
| IPR005821 | Ion transport domain |
| IPR016093 | MIR_motif |
| IPR000699 | RIH (RyR and IP3R Homology) domain |
| IPR013662 | RyR/IP3R Homology associated domain |
| IPR015925 | Ryanodine receptor-related |
UniProt Annotations
Entry Information
Gene Name
inositol 1,4,5-trisphosphate receptor, type 3
Protein Entry
ITPR3_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Domain | The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. |
| Function | Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. |
| Ptm | Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues (By similarity) |
| Similarity | Belongs to the InsP3 receptor family |
| Similarity | Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . |
| Subunit | Homotetramer. Interacts with SIGMAR1, AKT1, PML and CABP1. Interacts with TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with TMBIM4/LFG4 (By similarity). Interacts with LRMP (via coiled-coil domain) (By similarity). Interacts with CEMIP (By similarity). Interacts with TESPA1 (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012545 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6981110 | RefSeq | NP_037270 | 2670 | inositol 1,4,5-trisphosphate receptor type 3 |
Identical Sequences to LMP012545 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981110 | GenBank | AAA41446.1 | 2670 | inositol triphosphate receptor subtype 3 [Rattus norvegicus] |
| GI:6981110 | SwissProt | Q63269.1 | 2670 | RecName: Full=Inositol 1,4,5-trisphosphate receptor type 3; AltName: Full=IP3 receptor isoform 3; Short=IP3R 3; Short=InsP3R3; AltName: Full=Type 3 inositol 1,4,5-trisphosphate receptor; Short=Type 3 InsP3 receptor [Rattus norvegicus] |
Related Sequences to LMP012545 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6981110 | GenBank | AAA41446.1 | 2670 | inositol triphosphate receptor subtype 3 [Rattus norvegicus] |
| GI:6981110 | RefSeq | XP_008770932.1 | 2670 | PREDICTED: inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [Rattus norvegicus] |
| GI:6981110 | SwissProt | Q63269.1 | 2670 | RecName: Full=Inositol 1,4,5-trisphosphate receptor type 3; AltName: Full=IP3 receptor isoform 3; Short=IP3R 3; Short=InsP3R3; AltName: Full=Type 3 inositol 1,4,5-trisphosphate receptor; Short=Type 3 InsP3 receptor [Rattus norvegicus] |