Gene/Proteome Database (LMPD)

LMPD ID
LMP012543
Gene ID
25672
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 3, group C, member 2
Gene Symbol
Nr3c2
Synonyms
MCR; Mlr;
Alternate Names
mineralocorticoid receptor; MR; Mineralocorticoid receptor (aldosterone receptor);
Chromosome
19
Map Location
19q11
Summary
mineralocorticoid receptor; involved in renal sodium and water regulation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr3c2

Proteins

mineralocorticoid receptor
Refseq ID NP_037263
Protein GI 6981208
UniProt ID P22199
mRNA ID NM_013131
Length 981
METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK

Gene Information

Entrez Gene ID
25672
Gene Name
nuclear receptor subfamily 3, group C, member 2
Gene Symbol
Nr3c2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005634 IDA:RGD C nucleus
GO:0003690 IDA:RGD F double-stranded DNA binding
GO:0042562 IDA:RGD F hormone binding
GO:0017082 IDA:RGD F mineralocorticoid receptor activity
GO:0046982 IDA:RGD F protein heterodimerization activity
GO:0042803 IDA:RGD F protein homodimerization activity
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 IMP:RGD F sequence-specific DNA binding transcription factor activity
GO:0005496 IDA:RGD F steroid binding
GO:0003707 IMP:RGD F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0031959 IMP:RGD P mineralocorticoid receptor signaling pathway
GO:0042127 IDA:RGD P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
ko04960 Aldosterone-regulated sodium reabsorption
rno04960 Aldosterone-regulated sodium reabsorption

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 3, group C, member 2
Protein Entry
MCR_RAT
UniProt ID
P22199
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P22199-1; Sequence=Displayed; Name=2; IsoId=P22199-2; Sequence=VSP_003705; Name=3; IsoId=P22199-3; Sequence=VSP_007361, VSP_007362; Note=Very low transactivation activity, not increased by aldosterone.;
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Ptm Phosphorylated
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Cytoplasm . Nucleus . Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (By similarity)
Subunit Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. Binds the coactivator NCOA2. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, TIF1 and NRIP1 (By similarity)
Tissue Specificity Detected in liver, brain, heart, kidney, colon, aorta, hippocampus, hypothalamus and adrenal fasciculata

Identical and Related Proteins

Unique RefSeq proteins for LMP012543 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981208 RefSeq NP_037263 981 mineralocorticoid receptor

Identical Sequences to LMP012543 proteins

Reference Database Accession Length Protein Name
GI:6981208 GenBank AAA41583.1 981 mineralocorticoid receptor [Rattus norvegicus]
GI:6981208 SwissProt P22199.1 981 RecName: Full=Mineralocorticoid receptor; Short=MR; AltName: Full=Nuclear receptor subfamily 3 group C member 2 [Rattus norvegicus]

Related Sequences to LMP012543 proteins

Reference Database Accession Length Protein Name
GI:6981208 GenBank AAA41583.1 981 mineralocorticoid receptor [Rattus norvegicus]
GI:6981208 GenBank AAI33714.1 980 Nr3c2 protein [Mus musculus]
GI:6981208 SwissProt P22199.1 981 RecName: Full=Mineralocorticoid receptor; Short=MR; AltName: Full=Nuclear receptor subfamily 3 group C member 2 [Rattus norvegicus]