Gene/Proteome Database (LMPD)

LMPD ID
LMP012542
Gene ID
25666
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase, gamma
Gene Symbol
Dgkg
Synonyms
Dagk3; DGKIII;
Alternate Names
diacylglycerol kinase gamma; DGK-gamma; DAG kinase gamma; diglyceride kinase gamma; 88 kDa diacylglycerol kinase; Diacylglycerol kinase 3 (gamma);
Chromosome
11
Map Location
11q23
EC Number
2.7.1.107
Summary
putative diacylglycerol kinase associated with the cytoskeleton of purkinje cells [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dgkg

Proteins

diacylglycerol kinase gamma
Refseq ID NP_037258
Protein GI 6978761
UniProt ID P49620
mRNA ID NM_013126
Length 788
MSDGQWVCLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLKQYDPHKPISYDVFKLFMRAYLEVDLPQPLSTNLFLAFSQKPRQETPDHPKEGASSSEPNVSDSNAESTAKADAACAPDTESKPIKTQVPSEELEAAAPWGEPNAPASSSDAPIVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTELRPILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLLVLLGMDDSASKGDGRHAWTLKHFKKPTYCNFCHIMLMGVRKQGLCCIYCKYAVHQRCVSNSIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTACDGGELKDHILLPTSIYPVTRDRQAGKSDSGAAAKGELVMQYKIIPSPGTHPLLVLVNPKSGGRQGERILQKFHYLLNPKQVFNLDKGGPTPGLNFFQDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKLLPMQVDGEPWMQPPCMIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD

Gene Information

Entrez Gene ID
25666
Gene Name
diacylglycerol kinase, gamma
Gene Symbol
Dgkg
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043231 IEA:Ensembl C intracellular membrane-bounded organelle
GO:0005886 IEA:Ensembl C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004143 IDA:RGD F diacylglycerol kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0048666 IEP:RGD P neuron development
GO:0007205 TAS:RGD P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953655 Effects of PIP2 hydrolysis
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953644 Platelet activation, signaling and aggregation
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR029477 Diacylglycerol kinase type I, N-terminal
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, gamma
Protein Entry
DGKG_RAT
UniProt ID
P49620
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Similarity Belongs to the eukaryotic diacylglycerol kinase family
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers
Tissue Specificity Expressed specifically in brain and localized predominantly in cerebellar Purkinje cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP012542 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978761 RefSeq NP_037258 788 diacylglycerol kinase gamma

Identical Sequences to LMP012542 proteins

Reference Database Accession Length Protein Name
GI:6978761 DBBJ BAA07480.1 788 88kDa-diacylglycerol kinase [Rattus norvegicus]
GI:6978761 PIR - 788 diacylglycerol kinase (EC 2.7.1.107) gamma - rat [Rattus sp.]
GI:6978761 SwissProt P49620.1 788 RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=88 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Rattus norvegicus]

Related Sequences to LMP012542 proteins

Reference Database Accession Length Protein Name
GI:6978761 DBBJ BAA07480.1 788 88kDa-diacylglycerol kinase [Rattus norvegicus]
GI:6978761 PIR - 788 diacylglycerol kinase (EC 2.7.1.107) gamma - rat [Rattus sp.]
GI:6978761 SwissProt P49620.1 788 RecName: Full=Diacylglycerol kinase gamma; Short=DAG kinase gamma; AltName: Full=88 kDa diacylglycerol kinase; AltName: Full=Diglyceride kinase gamma; Short=DGK-gamma [Rattus norvegicus]