Gene/Proteome Database (LMPD)

LMPD ID
LMP012540
Gene ID
25652
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin F receptor
Gene Symbol
Ptgfr
Synonyms
PF2AR;
Alternate Names
prostaglandin F2-alpha receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor;
Chromosome
2
Map Location
2q45
Summary
receptor for prostaglandin F2; activation induces signaling via increased intracellular calcium [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ptgfr

Proteins

prostaglandin F2-alpha receptor
Refseq ID NP_037247
Protein GI 6981436
UniProt ID P43118
mRNA ID NM_013115
Length 366
MSINSSKQPASSAAGLIANTTCQTENRLSVFFSIIFMTVGIVSNSLAIAILMKAYQRFRRKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSVFGISMVFSGLCPLFLGSTMAIERCIGVTNPLFHSTKITSKHVKMILSGVCMFAVFVALLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSSLGLLALGISFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMVIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKENQQASSEAGL

Gene Information

Entrez Gene ID
25652
Gene Name
prostaglandin F receptor
Gene Symbol
Ptgfr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005576 IEA:Ensembl C extracellular region
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004958 IEA:Ensembl F prostaglandin F receptor activity
GO:0035584 IEA:Ensembl P calcium-mediated signaling using intracellular calcium source
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954201 Prostanoid ligand receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000141 Prostaglandin F receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin F receptor
Protein Entry
PF2R_RAT
UniProt ID
P43118
Species
Rat

Comments

Comment Type Description
Function Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Highest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP012540 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981436 RefSeq NP_037247 366 prostaglandin F2-alpha receptor

Identical Sequences to LMP012540 proteins

Reference Database Accession Length Protein Name
GI:6981436 GenBank EDL82479.1 366 prostaglandin F receptor, isoform CRA_a [Rattus norvegicus]
GI:6981436 GenBank EDL82480.1 366 prostaglandin F receptor, isoform CRA_a [Rattus norvegicus]
GI:6981436 RefSeq XP_006233548.1 366 PREDICTED: prostaglandin F2-alpha receptor isoform X1 [Rattus norvegicus]
GI:6981436 RefSeq XP_006233549.1 366 PREDICTED: prostaglandin F2-alpha receptor isoform X1 [Rattus norvegicus]

Related Sequences to LMP012540 proteins

Reference Database Accession Length Protein Name
GI:6981436 EMBL CAA58736.1 366 F2alpha receptor [Rattus norvegicus]
GI:6981436 GenBank AAB32739.1 366 prostaglandin F2 alpha receptor [Rattus sp.]
GI:6981436 SwissProt P43118.1 366 RecName: Full=Prostaglandin F2-alpha receptor; Short=PGF receptor; Short=PGF2-alpha receptor; AltName: Full=Prostanoid FP receptor [Rattus norvegicus]