Gene/Proteome Database (LMPD)

LMPD ID
LMP012519
Gene ID
25524
Species
Rattus norvegicus (Rat)
Gene Name
prosaposin
Gene Symbol
Psap
Synonyms
SGP-1; SGP1A;
Alternate Names
sulfated glycoprotein 1; prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator);
Chromosome
20
Map Location
20q11
Summary
may play a role in glycolipid transport during spermatogenesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Psap

Proteins

sulfated glycoprotein 1 isoform A preproprotein
Refseq ID NP_037145
Protein GI 298231223
UniProt ID Q6P7A4
mRNA ID NM_013013
Length 554
MYALALLASLLVTALTSPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNMETAARCNAVDHCKRHVWN
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT mat_peptide: 17..554 product: Sulfated glycoprotein 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P10960.1) calculated_mol_wt: 59522 peptide sequence: SPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNMETAARCNAVDHCKRHVWN
sulfated glycoprotein 1 isoform B preproprotein
Refseq ID NP_001177165
Protein GI 298231225
UniProt ID Q6P7A4
mRNA ID NM_001190236
Length 557
MYALALLASLLVTALTSPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQDQQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNMETAARCNAVDHCKRHVWN
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT
sulfated glycoprotein 1 isoform C preproprotein
Refseq ID NP_001177166
Protein GI 298231227
UniProt ID Q6P7A4
mRNA ID NM_001190237
Length 556
MYALALLASLLVTALTSPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQDQQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNMETAARCNAVDHCKRHVWN
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT
sulfated glycoprotein 1 isoform D preproprotein
Refseq ID NP_001177167
Protein GI 298231229
UniProt ID Q6P7A4
mRNA ID NM_001190238
Length 553
MYALALLASLLVTALTSPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNMETAARCNAVDHCKRHVWN
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1664 peptide sequence: MYALALLASLLVTALT

Gene Information

Entrez Gene ID
25524
Gene Name
prosaposin
Gene Symbol
Psap
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IEA:Ensembl C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IEA:InterPro C lysosome
GO:0005739 IEA:Ensembl C mitochondrion
GO:0071310 IEA:Ensembl P cellular response to organic substance
GO:0060742 IEA:Ensembl P epithelial cell differentiation involved in prostate gland development
GO:0060736 IEA:Ensembl P prostate gland growth
GO:0043408 IEA:Ensembl P regulation of MAPK cascade
GO:0019216 IEA:Ensembl P regulation of lipid metabolic process
GO:0006665 IEA:InterPro P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
rno04142 Lysosome

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5953758 GPCR ligand binding
5954485 Glycosphingolipid metabolism
5953645 Hemostasis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954121 Peptide ligand-binding receptors
5953644 Platelet activation, signaling and aggregation
5954102 Platelet degranulation
5953646 Response to elevated platelet cytosolic Ca2+
5953381 Signal Transduction
5953391 Signaling by GPCR
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR008373 Saposin
IPR008139 Saposin B
IPR003119 Saposin type A
IPR021165 Saposin, chordata
IPR011001 Saposin-like
IPR007856 Saposin-like type B, 1
IPR008138 Saposin-like type B, 2

UniProt Annotations

Entry Information

Gene Name
prosaposin
Protein Entry
Q6P7A4_RAT
UniProt ID
Q6P7A4
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012519 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
298231223 RefSeq NP_037145 554 sulfated glycoprotein 1 isoform A preproprotein
298231225 RefSeq NP_001177165 557 sulfated glycoprotein 1 isoform B preproprotein
298231227 RefSeq NP_001177166 556 sulfated glycoprotein 1 isoform C preproprotein
298231229 RefSeq NP_001177167 553 sulfated glycoprotein 1 isoform D preproprotein

Identical Sequences to LMP012519 proteins

Reference Database Accession Length Protein Name
GI:298231229 GenBank AAH61759.1 553 Prosaposin [Rattus norvegicus]
GI:298231225 GenBank EDL93051.1 557 prosaposin, isoform CRA_b [Rattus norvegicus]
GI:298231223 GenBank EDL93053.1 554 prosaposin, isoform CRA_d [Rattus norvegicus]

Related Sequences to LMP012519 proteins

Reference Database Accession Length Protein Name
GI:298231229 GenBank AAH61759.1 553 Prosaposin [Rattus norvegicus]
GI:298231225 GenBank EDL93050.1 550 prosaposin, isoform CRA_a [Rattus norvegicus]
GI:298231223 GenBank EDL93050.1 550 prosaposin, isoform CRA_a [Rattus norvegicus]
GI:298231225 GenBank EDL93051.1 557 prosaposin, isoform CRA_b [Rattus norvegicus]
GI:298231223 GenBank EDL93053.1 554 prosaposin, isoform CRA_d [Rattus norvegicus]
GI:298231229 GenBank AEK13605.1 554 Sequence 17 from patent US 7972785
GI:298231227 RefSeq XP_005360121.1 552 PREDICTED: sulfated glycoprotein 1-like isoform X1 [Microtus ochrogaster]
GI:298231227 RefSeq XP_005360122.1 557 PREDICTED: sulfated glycoprotein 1-like isoform X2 [Microtus ochrogaster]
GI:298231225 RefSeq XP_006256465.1 556 PREDICTED: sulfated glycoprotein 1 isoform X1 [Rattus norvegicus]
GI:298231227 RefSeq XP_006256465.1 556 PREDICTED: sulfated glycoprotein 1 isoform X1 [Rattus norvegicus]
GI:298231223 RefSeq XP_006256465.1 556 PREDICTED: sulfated glycoprotein 1 isoform X1 [Rattus norvegicus]
GI:298231229 SwissProt P10960.1 554 RecName: Full=Sulfated glycoprotein 1; Short=SGP-1; AltName: Full=Prosaposin; Flags: Precursor [Rattus norvegicus]