Gene/Proteome Database (LMPD)

LMPD ID
LMP012498
Gene ID
25318
Species
Rattus norvegicus (Rat)
Gene Name
farnesyltransferase, CAAX box, alpha
Gene Symbol
Fnta
Synonyms
PFAS;
Alternate Names
protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; FTase-alpha; GGTase-I-alpha; Farnesyltransferase, subunit alpha; CAAX farnesyltransferase subunit alpha; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha;
Chromosome
16
Map Location
16q12.4
EC Number
2.5.1.58
Summary
subunit of the heterodimeric p21ras protein farnesyltransferase that attaches farnesyl residues to a cysteine at the fourth position from the C-terminus; may function as farnesyl pyrophosphate carrier [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Fnta

Proteins

protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Refseq ID NP_036979
Protein GI 6978849
UniProt ID Q04631
mRNA ID NM_012847
Length 377
MAATEGVGESAPGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSRESDIPASV

Gene Information

Entrez Gene ID
25318
Gene Name
farnesyltransferase, CAAX box, alpha
Gene Symbol
Fnta
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005953 IDA:RGD C CAAX-protein geranylgeranyltransferase complex
GO:0005737 IDA:RGD C cytoplasm
GO:0005965 ISS:UniProtKB C protein farnesyltransferase complex
GO:0004662 IEA:UniProtKB-EC F CAAX-protein geranylgeranyltransferase activity
GO:0004660 IDA:RGD F protein farnesyltransferase activity
GO:0004661 ISS:UniProtKB F protein geranylgeranyltransferase activity
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0051771 IMP:RGD P negative regulation of nitric-oxide synthase biosynthetic process
GO:0045787 IMP:RGD P positive regulation of cell cycle
GO:0008284 IMP:RGD P positive regulation of cell proliferation
GO:0051770 IMP:RGD P positive regulation of nitric-oxide synthase biosynthetic process
GO:0018343 ISS:UniProtKB P protein farnesylation
GO:0018344 ISS:UniProtKB P protein geranylgeranylation
GO:0034097 IMP:RGD P response to cytokine
GO:0010035 IMP:RGD P response to inorganic substance
GO:0014070 IMP:RGD P response to organic cyclic compound

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953314 Apoptosis
5954021 Apoptotic cleavage of cellular proteins
5954022 Apoptotic execution phase
5953253 Disease
5953382 Diseases associated with visual transduction
5953378 Inactivation, recovery and regulation of the phototransduction cascade
5953381 Signal Transduction
5953379 The phototransduction cascade
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR002088 Protein prenyltransferase, alpha subunit

UniProt Annotations

Entry Information

Gene Name
farnesyltransferase, CAAX box, alpha
Protein Entry
FNTA_RAT
UniProt ID
Q04631
Species
Rat

Comments

Comment Type Description
Catalytic Activity Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Catalytic Activity Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Enzyme Regulation Activated by the AGRIN-induced phosphorylation which is mediated by MUSK
Function Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:22963166}.
Interaction Q02293:Fntb; NbExp=14; IntAct=EBI-602447, EBI-602454; P01116-2:KRAS (xeno); NbExp=2; IntAct=EBI-602447, EBI-367427; P53610:Pggt1b; NbExp=5; IntAct=EBI-602447, EBI-602610;
Ptm Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity)
Similarity Belongs to the protein prenyltransferase subunit alpha family
Similarity Contains 5 PFTA repeats. {ECO:0000255|PROSITE- ProRule:PRU00488}.
Subunit Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase). {ECO:0000250, ECO:0000269|PubMed:10377218, ECO:0000269|PubMed:10673434, ECO:0000269|PubMed:11687658, ECO:0000269|PubMed:12374986, ECO:0000269|PubMed:12657282, ECO:0000269|PubMed:12667062, ECO:0000269|PubMed:14609943, ECO:0000269|PubMed:15170324, ECO:0000269|PubMed:15451670, ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:19219049, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:9065406, ECO:0000269|PubMed:9609683, ECO:0000269|PubMed:9657673, ECO:0000269|PubMed:9843427}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012498 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978849 RefSeq NP_036979 377 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Identical Sequences to LMP012498 proteins

Reference Database Accession Length Protein Name
GI:6978849 PDB 4GTO 377 Chain A, Ftase In Complex With Bms Analogue 14
GI:6978849 PDB 4GTP 377 Chain A, Ftase In Complex With Bms Analogue 16
GI:6978849 PDB 4GTQ 377 Chain A, Ftase In Complex With Bms Analogue 12
GI:6978849 PDB 4GTR 377 Chain A, Ftase In Complex With Bms Analogue 13

Related Sequences to LMP012498 proteins

Reference Database Accession Length Protein Name
GI:6978849 PDB 3EUV 377 Chain A, Crystal Structure Of Ftase(Alpha-Subunit; Beta-Subunit Delta C10, W102t, Y154t) In Complex With Biotingpp
GI:6978849 PDB 4GTM 377 Chain A, Ftase In Complex With Bms Analogue 11
GI:6978849 PDB 4GTO 377 Chain A, Ftase In Complex With Bms Analogue 14