Gene/Proteome Database (LMPD)

LMPD ID
LMP012488
Gene ID
25271
Species
Rattus norvegicus (Rat)
Gene Name
retinoid X receptor alpha
Gene Symbol
Rxra
Alternate Names
retinoic acid receptor RXR-alpha; nuclear receptor subfamily 2 group B member 1;
Chromosome
3
Map Location
3p12
Summary
displays 9-cis retinoic acid-dependent binding to transcription factor GATA-4 and corepressor FOG-2; regulates cardiac gene expression [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rxra

Proteins

retinoic acid receptor RXR-alpha
Refseq ID NP_036937
Protein GI 148747360
UniProt ID Q0VJ96
mRNA ID NM_012805
Length 467
MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT

Gene Information

Entrez Gene ID
25271
Gene Name
retinoid X receptor alpha
Gene Symbol
Rxra
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000790 IEA:Ensembl C nuclear chromatin
GO:0004886 IEA:Ensembl F 9-cis retinoic acid receptor activity
GO:0000977 IEA:Ensembl F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0031490 IEA:Ensembl F chromatin DNA binding
GO:0044323 IEA:Ensembl F retinoic acid-responsive element binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0070644 IEA:Ensembl F vitamin D response element binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0043010 IEA:Ensembl P camera-type eye development
GO:0060038 IEA:Ensembl P cardiac muscle cell proliferation
GO:0007566 IEA:Ensembl P embryo implantation
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001893 IEA:Ensembl P maternal placenta development
GO:0019048 IEA:Ensembl P modulation by virus of host morphology or physiology
GO:0000122 IEA:Ensembl P negative regulation of transcription from RNA polymerase II promoter
GO:0035357 IEA:Ensembl P peroxisome proliferator activated receptor signaling pathway
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0051289 IEA:Ensembl P protein homotetramerization
GO:0060687 IEA:Ensembl P regulation of branching involved in prostate gland morphogenesis
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0060528 IEA:Ensembl P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0055012 IEA:Ensembl P ventricular cardiac muscle cell differentiation
GO:0055010 IEA:Ensembl P ventricular cardiac muscle tissue morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko04976 Bile secretion
rno04976 Bile secretion
ko05160 Hepatitis C
rno05160 Hepatitis C
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
rno05200 Pathways in cancer
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko05216 Thyroid cancer
rno05216 Thyroid cancer
rno04919 Thyroid hormone signaling pathway
ko05202 Transcriptional misregulation in cancer
rno05202 Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5954332 BMAL1:CLOCK,NPAS2 activates circadian gene expression
5953720 Bile acid and bile salt metabolism
5953258 Biological oxidations
5954223 Circadian Clock
5953485 Cytochrome P450 - arranged by substrate type
5953533 Developmental Biology
5953932 Endogenous sterols
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953330 Gene Expression
5953833 Generic Transcription Pathway
5953467 Import of palmitoyl-CoA into the mitochondrial matrix
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953600 Mitochondrial biogenesis
5954147 Nuclear Receptor transcription pathway
5953601 Organelle biogenesis and maintenance
5954333 PPARA activates gene expression
5953326 Phase 1 - Functionalization of compounds
5953268 Pyruvate metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5954224 REV-ERBA represses gene expression
5954225 RORA activates circadian gene expression
5953719 Recycling of bile acids and salts
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954047 Regulation of pyruvate dehydrogenase (PDH) complex
5953930 Synthesis of bile acids and bile salts
5953929 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5953931 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5953270 The citric acid (TCA) cycle and respiratory electron transport
5953599 Transcriptional activation of mitochondrial biogenesis
5954166 Transcriptional regulation of white adipocyte differentiation
5954528 YAP1- and WWTR1 (TAZ)-stimulated gene expression

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR021780 Nuclear/hormone receptor activator site AF-1
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor alpha
Protein Entry
Q0VJ96_RAT
UniProt ID
Q0VJ96
Species
Rat

Comments

Comment Type Description
Similarity Belongs to the nuclear hormone receptor family
Similarity Contains nuclear receptor DNA-binding domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012488 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148747360 RefSeq NP_036937 467 retinoic acid receptor RXR-alpha

Identical Sequences to LMP012488 proteins

Reference Database Accession Length Protein Name
GI:148747360 EMBL CAL25727.1 467 retinoid X receptor alpha [Rattus norvegicus]
GI:148747360 EMBL CAL25728.1 467 retinoid X receptor alpha [Rattus norvegicus]
GI:148747360 EMBL CAL36079.1 467 retinoid X receptor alpha [Rattus norvegicus]
GI:148747360 GenBank EDL93429.1 467 retinoid X receptor alpha, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012488 proteins

Reference Database Accession Length Protein Name
GI:148747360 EMBL CAL25727.1 467 retinoid X receptor alpha [Rattus norvegicus]
GI:148747360 EMBL CAL25728.1 467 retinoid X receptor alpha [Rattus norvegicus]
GI:148747360 GenBank EDL93429.1 467 retinoid X receptor alpha, isoform CRA_a [Rattus norvegicus]