Gene/Proteome Database (LMPD)

LMPD ID
LMP012481
Gene ID
25244
Species
Rattus norvegicus (Rat)
Gene Name
branched chain ketoacid dehydrogenase E1, alpha polypeptide
Gene Symbol
Bckdha
Synonyms
E1a; BCKDA;
Alternate Names
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; BCKDE1A; BCKDH E1-alpha; branched chain alpha-ketoacid dehydrogenase subunit E1 alpha; branched chain keto acid dehydrogenase subunit E1, alpha polypeptide; branched-chain alpha-keto acid dehydrogenase E1 component alpha chain;
Chromosome
1
Map Location
1q21
Summary
plays a role in the conversion of 3-methyl-2-oxobutanoate and lipoamide to S-(2-methylpropanoyl)dihydrolipoamide and CO2 [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Bckdha

Proteins

2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
Refseq ID NP_036914
Protein GI 77736548
UniProt ID Q5EB89
mRNA ID NM_012782
Length 446
MAVAMSAAKIWRPSRGLRQAALLLLGRPGARGLARFHPSRQQQQQFPSLDDKPQFPGASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEVLKLYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAGVLMYRDYPLELFMAQCYGNVSDPGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYAAKRANANQIVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDSSAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFEQAERKLKPNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDHFDK

Gene Information

Entrez Gene ID
25244
Gene Name
branched chain ketoacid dehydrogenase E1, alpha polypeptide
Gene Symbol
Bckdha
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:Ensembl C mitochondrion
GO:0016624 IEA:InterPro F oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

KEGG Pathway Links

KEGG Pathway ID Description
M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA
rno01100 Metabolic pathways
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953282 Branched-chain amino acid catabolism
5953250 Metabolism
5953272 Metabolism of amino acids and derivatives

Domain Information

InterPro Annotations

Accession Description
IPR001017 Dehydrogenase, E1 component
IPR029061 Thiamin diphosphate-binding fold

UniProt Annotations

Entry Information

Gene Name
branched chain ketoacid dehydrogenase E1, alpha polypeptide
Protein Entry
Q5EB89_RAT
UniProt ID
Q5EB89
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012481 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
77736548 RefSeq NP_036914 446 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

Identical Sequences to LMP012481 proteins

Reference Database Accession Length Protein Name
GI:77736548 GenBank AAI61819.1 446 Branched chain ketoacid dehydrogenase E1, alpha polypeptide [Rattus norvegicus]

Related Sequences to LMP012481 proteins

Reference Database Accession Length Protein Name
GI:77736548 GenBank AAA40811.1 441 branched chain alpha-ketoacid dehydrogenase precursor, partial [Rattus norvegicus]
GI:77736548 GenBank AAI61819.1 446 Branched chain ketoacid dehydrogenase E1, alpha polypeptide [Rattus norvegicus]
GI:77736548 SwissProt P11960.1 441 RecName: Full=2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; AltName: Full=Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; Short=BCKDE1A; Short=BCKDH E1-alpha; Flags: Precursor, partial [Rattus norvegicus]