Gene/Proteome Database (LMPD)

LMPD ID
LMP012476
Gene ID
25147
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Gene Symbol
Cyp19a1
Synonyms
Cyp19; Cyp19a; p450arom; Aromatase;
Alternate Names
aromatase; CYPXIX; P-450AROM; estrogen synthase; estrogen synthetase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, subfamily 19; Cytochrome P450, 19, aromatase; cytochrome P450 family 19 subfamily a;
Chromosome
8
Map Location
8q23-q24
Summary
catalyzes end-step estrogen formation from androgens and aromatization of testosterone to estradiol [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp19a1

Proteins

aromatase
Refseq ID NP_058781
Protein GI 281182626
mRNA ID NM_017085
Length 503
MFLEMLNPMHYNVTIMVPETVPVSAMPLLLIMGLLLLIRNCESSSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSSMVHVMKHSNYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTDNSGYVDVVTLMRHIMLDTSNTLFLGIPLDESSIVKKIQGYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLEDCMDFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVGDRDIRIGDVQNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHVKTLQKRCIENMPKNNDLSLHLDEDSPIVEIIFSPRNSEKYLKQ

Gene Information

Entrez Gene ID
25147
Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Gene Symbol
Cyp19a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043679 IDA:RGD C axon terminus
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0043197 IDA:RGD C dendritic spine
GO:0005783 IDA:RGD C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0043025 IDA:RGD C neuronal cell body
GO:0045202 IDA:RGD C synapse
GO:0008021 IDA:RGD C synaptic vesicle
GO:0043195 IDA:RGD C terminal bouton
GO:0070330 IDA:RGD F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016712 IDA:RGD F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0008207 IDA:RGD P C21-steroid hormone metabolic process
GO:0030325 IEP:RGD P adrenal gland development
GO:0008209 IMP:RGD P androgen metabolic process
GO:0008206 IEP:RGD P bile acid metabolic process
GO:0018879 IEP:RGD P biphenyl metabolic process
GO:0060348 IEP:RGD P bone development
GO:0044344 IEP:RGD P cellular response to fibroblast growth factor stimulus
GO:0071372 IEP:RGD P cellular response to follicle-stimulating hormone stimulus
GO:0071333 IEP:RGD P cellular response to glucose stimulus
GO:0071371 IEP:RGD P cellular response to gonadotropin stimulus
GO:0071464 IEP:RGD P cellular response to hydrostatic pressure
GO:0018894 IEP:RGD P dibenzo-p-dioxin metabolic process
GO:0006703 IDA:RGD P estrogen biosynthetic process
GO:0030851 IEP:RGD P granulocyte differentiation
GO:0021766 IEP:RGD P hippocampus development
GO:0021854 IEP:RGD P hypothalamus development
GO:0001553 IEP:RGD P luteinization
GO:0008584 IEP:RGD P male gonad development
GO:0030186 IEP:RGD P melatonin metabolic process
GO:0045779 IMP:RGD P negative regulation of bone resorption
GO:0018963 IEP:RGD P phthalate metabolic process
GO:0042448 IEP:RGD P progesterone metabolic process
GO:0050803 IMP:RGD P regulation of synapse structure and activity
GO:0010164 IEP:RGD P response to cesium ion
GO:0042493 IEP:RGD P response to drug
GO:0032355 IEP:RGD P response to estradiol
GO:0043627 IEP:RGD P response to estrogen
GO:0009635 IEP:RGD P response to herbicide
GO:0010212 IEP:RGD P response to ionizing radiation
GO:0010038 IEP:RGD P response to metal ion
GO:0043278 IEP:RGD P response to morphine
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0033574 IEP:RGD P response to testosterone

KEGG Pathway Links

KEGG Pathway ID Description
M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
rno01100 Metabolic pathways
ko04913 Ovarian steroidogenesis
rno04913 Ovarian steroidogenesis
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 19, subfamily a, polypeptide 1
Species
Rat

Comments

Comment Type Description
Catalytic Activity Androst-4-ene-3,17-dione + 3 O(2) + 3 reduced flavoproteins = estrone + formate + 4 H(2)O + 3 oxidized flavoproteins.
Catalytic Activity Testosterone + 3 O(2) + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H(2)O + 3 oxidized flavoproteins.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Function Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012476 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
281182626 RefSeq NP_058781 503 aromatase

Identical Sequences to LMP012476 proteins

Reference Database Accession Length Protein Name
GI:281182626 GenBank EDL95528.1 503 cytochrome P450, family 19, subfamily a, polypeptide 1, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012476 proteins

Reference Database Accession Length Protein Name
GI:281182626 GenBank AAA41044.1 508 aromatase cytochrome P450 [Rattus norvegicus]
GI:281182626 GenBank EDL95528.1 503 cytochrome P450, family 19, subfamily a, polypeptide 1, isoform CRA_a [Rattus norvegicus]
GI:281182626 SwissProt P22443.1 508 RecName: Full=Aromatase; AltName: Full=CYPXIX; AltName: Full=Cytochrome P-450AROM; AltName: Full=Cytochrome P450 19A1; AltName: Full=Estrogen synthase [Rattus norvegicus]