Gene/Proteome Database (LMPD)

LMPD ID
LMP012471
Gene ID
25114
Species
Rattus norvegicus (Rat)
Gene Name
fibroblast growth factor receptor 4
Gene Symbol
Fgfr4
Alternate Names
fibroblast growth factor receptor 4; FGFR-4;
Chromosome
17
Map Location
17p14
EC Number
2.7.10.1
Summary
fibroblast growth factor receptor subtype expressed in lung and kidney [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Fgfr4

Proteins

fibroblast growth factor receptor 4 precursor
Refseq ID NP_001103374
Protein GI 158186625
UniProt ID Q498D6
mRNA ID NM_001109904
Length 800
MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1846 peptide sequence: MWLLLALLSIFQETPA mat_peptide: 17..800 product: Fibroblast growth factor receptor 4 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q498D6.1) calculated_mol_wt: 86880 peptide sequence: FSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT

Gene Information

Entrez Gene ID
25114
Gene Name
fibroblast growth factor receptor 4
Gene Symbol
Fgfr4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005911 IEA:Ensembl C cell-cell junction
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0005887 ISS:UniProtKB C integral component of plasma membrane
GO:0005634 IEA:Ensembl C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0017134 ISS:UniProtKB F fibroblast growth factor binding
GO:0005007 IPI:MGI F fibroblast growth factor-activated receptor activity
GO:0008201 ISS:UniProtKB F heparin binding
GO:0061144 IEA:Ensembl P alveolar secondary septum development
GO:0016477 ISS:UniProtKB P cell migration
GO:0008543 IPI:MGI P fibroblast growth factor receptor signaling pathway
GO:0042593 ISS:UniProtKB P glucose homeostasis
GO:0001759 IEA:Ensembl P organ induction
GO:0018108 ISS:UniProtKB P peptidyl-tyrosine phosphorylation
GO:0055062 ISS:UniProtKB P phosphate ion homeostasis
GO:2000573 ISS:UniProtKB P positive regulation of DNA biosynthetic process
GO:0070374 ISS:UniProtKB P positive regulation of ERK1 and ERK2 cascade
GO:0008284 ISS:UniProtKB P positive regulation of cell proliferation
GO:0048554 ISS:UniProtKB P positive regulation of metalloenzyme activity
GO:0045862 ISS:UniProtKB P positive regulation of proteolysis
GO:0046777 ISS:UniProtKB P protein autophosphorylation
GO:0070857 ISS:UniProtKB P regulation of bile acid biosynthetic process
GO:2000188 ISS:UniProtKB P regulation of cholesterol homeostasis
GO:0010715 ISS:UniProtKB P regulation of extracellular matrix disassembly
GO:0019216 ISS:UniProtKB P regulation of lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04144 Endocytosis
rno04144 Endocytosis
ko04010 MAPK signaling pathway
rno04010 MAPK signaling pathway
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton
ko04550 Signaling pathways regulating pluripotency of stem cells
rno04550 Signaling pathways regulating pluripotency of stem cells

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5954570 Constitutive PI3K/AKT Signaling in Cancer
5953408 DAP12 interactions
5953407 DAP12 signaling
5953253 Disease
5953396 Downstream signal transduction
5953994 Downstream signaling events of B Cell Receptor (BCR)
5953399 Downstream signaling of activated FGFR
5953902 FGFR ligand binding and activation
5953909 FGFR4 ligand binding and activation
5953530 FRS2-mediated cascade
5953417 Fc epsilon receptor (FCERI) signaling
5953884 GAB1 signalosome
5953430 IGF1R signaling cascade
5953428 IRS-mediated signalling
5953425 IRS-related events
5953429 IRS-related events triggered by IGF1R
5953410 Immune System
5953409 Innate Immune System
5953422 Insulin receptor signalling cascade
5953911 Klotho-mediated ligand binding
5953394 NGF signalling via TRKA from the plasma membrane
5954379 Negative regulation of FGFR signaling
5953885 PI-3K cascade
5953432 PI3K Cascade
5953996 PI3K events in ERBB2 signaling
5953995 PI3K events in ERBB4 signaling
5953997 PI3K/AKT Signaling in Cancer
5953989 PI3K/AKT activation
5953993 PIP3 activates AKT signaling
5953398 Phospholipase C-mediated cascade
5953998 Role of LAT2/NTAL/LAB on calcium mobilization
5954432 SHC-mediated cascade
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953540 Signaling by ERBB4
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5954512 Signaling by FGFR mutants
5954532 Signaling by FGFR4 mutants
5953423 Signaling by Insulin receptor
5953397 Signaling by PDGF
5953541 Signaling by SCF-KIT
5953431 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF
5954452 betaKlotho-mediated ligand binding

Domain Information

InterPro Annotations

Accession Description
IPR016248 Fibroblast growth factor receptor family
IPR013098 Immunoglobulin I-set
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266 Tyrosine-protein kinase, active site
IPR020635 Tyrosine-protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
fibroblast growth factor receptor 4
Protein Entry
FGFR4_RAT
UniProt ID
Q498D6
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}.
Enzyme Regulation Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity)
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity)
Ptm Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer (By similarity)
Ptm N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19 (By similarity)
Ptm Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated (By similarity)
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily
Similarity Contains 1 protein kinase domain
Similarity Contains 3 Ig-like C2-type (immunoglobulin-like) domains
Subcellular Location Cell membrane; Single-pass type I membrane protein. Endosome . Endoplasmic reticulum . Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane
Subunit Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012471 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158186625 RefSeq NP_001103374 800 fibroblast growth factor receptor 4 precursor

Identical Sequences to LMP012471 proteins

Reference Database Accession Length Protein Name
GI:158186625 EMBL CBJ24608.1 800 unnamed protein product [Rattus sp.]
GI:158186625 GenBank AAI00261.1 800 Fibroblast growth factor receptor 4 [Rattus norvegicus]
GI:158186625 SwissProt Q498D6.1 800 RecName: Full=Fibroblast growth factor receptor 4; Short=FGFR-4; AltName: CD_antigen=CD334; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012471 proteins

Reference Database Accession Length Protein Name
GI:158186625 EMBL CBJ24608.1 800 unnamed protein product [Rattus sp.]
GI:158186625 GenBank AAI00261.1 800 Fibroblast growth factor receptor 4 [Rattus norvegicus]
GI:158186625 SwissProt Q498D6.1 800 RecName: Full=Fibroblast growth factor receptor 4; Short=FGFR-4; AltName: CD_antigen=CD334; Flags: Precursor [Rattus norvegicus]