Gene/Proteome Database (LMPD)

LMPD ID
LMP012468
Gene ID
25086
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 2, subfamily e, polypeptide 1
Gene Symbol
Cyp2e1
Synonyms
Cyp2e;
Alternate Names
cytochrome P450 2E1; P450-J; CYPIIE1; P450RLM6; cytochrome P450-J; cytochrome P450RLM6; 4-nitrophenol 2-hydroxylase; cytochrome P450, subfamily 2E, polypeptide 1; cytochrome P450 subfamily 2e1 (ethanol-inducible);
Chromosome
1
Map Location
1q41-q42
EC Number
1.14.13.-
Summary
facilitates hepatocyte sensitization to tumor necrosis factor-alpha (TNF-alpha)-mediated cell death; may play a role in xenobiotic metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp2e1

Proteins

cytochrome P450 2E1
Refseq ID NP_113731
Protein GI 13928734
UniProt ID P05182
mRNA ID NM_031543
Length 493
MAVLGITIALLVWVATLLVISIWKKIYNSWNLPPGPFPLPILGNIFQLDLKDIPKSFTKLAKRFGPVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYNDKKCLRLMSLFNENFYLLSTPWIQLYNNFADYLRYLPGSHRKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTVGFGSIPPQFKLCVIPRS

Gene Information

Entrez Gene ID
25086
Gene Name
cytochrome P450, family 2, subfamily e, polypeptide 1
Gene Symbol
Cyp2e1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 IDA:RGD C Golgi membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0031227 IDA:RGD C intrinsic component of endoplasmic reticulum membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0010181 IC:RGD F FMN binding
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 TAS:RGD F monooxygenase activity
GO:0016709 IEA:UniProtKB-EC F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712 IDA:RGD F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 IEA:Ensembl P drug metabolic process
GO:0046483 IEA:Ensembl P heterocycle metabolic process
GO:0016098 IEA:Ensembl P monoterpenoid metabolic process
GO:0055114 IDA:RGD P oxidation-reduction process
GO:0042493 IEP:RGD P response to drug
GO:0045471 IEP:RGD P response to ethanol
GO:0010243 IEP:RGD P response to organonitrogen compound
GO:0010193 IEP:RGD P response to ozone
GO:0008202 IEA:Ensembl P steroid metabolic process
GO:0006641 IMP:RGD P triglyceride metabolic process
GO:0006805 IMP:RGD P xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
ko05204 Chemical carcinogenesis
rno05204 Chemical carcinogenesis
ko00982 Drug metabolism - cytochrome P450
rno00982 Drug metabolism - cytochrome P450
ko00591 Linoleic acid metabolism
rno00591 Linoleic acid metabolism
rno01100 Metabolic pathways
ko00980 Metabolism of xenobiotics by cytochrome P450
rno00980 Metabolism of xenobiotics by cytochrome P450
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko00140 Steroid hormone biosynthesis
rno00140 Steroid hormone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953258 Biological oxidations
5953483 CYP2E1 reactions
5953485 Cytochrome P450 - arranged by substrate type
5953250 Metabolism
5953326 Phase 1 - Functionalization of compounds
5953484 Xenobiotics

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR008070 Cytochrome P450, E-class, group I, CYP2E-like
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily e, polypeptide 1
Protein Entry
CP2E1_RAT
UniProt ID
P05182
Species
Rat

Comments

Comment Type Description
Catalytic Activity 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence= ;
Function Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites
Induction By ethanol.
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012468 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13928734 RefSeq NP_113731 493 cytochrome P450 2E1

Identical Sequences to LMP012468 proteins

Reference Database Accession Length Protein Name
GI:13928734 GenBank AAA41060.1 493 cytochrome P450j [Rattus norvegicus]

Related Sequences to LMP012468 proteins

Reference Database Accession Length Protein Name
GI:13928734 GenBank AAA41060.1 493 cytochrome P450j [Rattus norvegicus]
GI:13928734 GenBank EDM11924.1 493 cytochrome P450, family 2, subfamily e, polypeptide 1, isoform CRA_d [Rattus norvegicus]
GI:13928734 SwissProt P05182.4 493 RecName: Full=Cytochrome P450 2E1; AltName: Full=4-nitrophenol 2-hydroxylase; AltName: Full=CYPIIE1; AltName: Full=Cytochrome P450-J; AltName: Full=Cytochrome P450RLM6 [Rattus norvegicus]