Gene/Proteome Database (LMPD)

LMPD ID
LMP012445
Gene ID
24886
Species
Rattus norvegicus (Rat)
Gene Name
thromboxane A synthase 1, platelet
Gene Symbol
Tbxas1
Alternate Names
thromboxane-A synthase; TXS; TXA synthase; cytochrome P450 5A1; ThromboxA ane synthase 1;
Chromosome
4
Map Location
4q21-q22
EC Number
5.3.99.5
Summary
catalyzes the conversion of prostaglandin H2 into thromboxane A2; mRNA expression increases in a model of hydronephrotic kidney; may play a role in response to injury [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Tbxas1

Proteins

thromboxane-A synthase
Refseq ID NP_036819
Protein GI 6981634
UniProt ID P49430
mRNA ID NM_012687
Length 533
MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR

Gene Information

Entrez Gene ID
24886
Gene Name
thromboxane A synthase 1, platelet
Gene Symbol
Tbxas1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:UniProtKB-KW F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0004796 IEA:UniProtKB-EC F thromboxane-A synthase activity
GO:0030644 IMP:RGD P cellular chloride ion homeostasis
GO:0045907 IMP:RGD P positive regulation of vasoconstriction
GO:0001516 IEA:UniProtKB-KW P prostaglandin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00590 Arachidonic acid metabolism
rno00590 Arachidonic acid metabolism
rno01100 Metabolic pathways
rno04611 Platelet activation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953493 Arachidonic acid metabolism
5953258 Biological oxidations
5953485 Cytochrome P450 - arranged by substrate type
5953491 Eicosanoids
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953326 Phase 1 - Functionalization of compounds
5953492 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
thromboxane A synthase 1, platelet
Protein Entry
THAS_RAT
UniProt ID
P49430
Species
Rat

Comments

Comment Type Description
Catalytic Activity (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha- epoxy-15-hydroxythromboxa-5,13-dienoate.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413;
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .
Subunit Monomer

Identical and Related Proteins

Unique RefSeq proteins for LMP012445 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6981634 RefSeq NP_036819 533 thromboxane-A synthase

Identical Sequences to LMP012445 proteins

Reference Database Accession Length Protein Name
GI:6981634 DBBJ BAA05962.1 533 thromboxane synthase [Rattus norvegicus]
GI:6981634 DBBJ BAA22574.1 533 thromboxane synthase [Rattus norvegicus]
GI:6981634 GenBank EDM15371.1 533 thromboxane A synthase 1 [Rattus norvegicus]
GI:6981634 SwissProt P49430.1 533 RecName: Full=Thromboxane-A synthase; Short=TXA synthase; Short=TXS; AltName: Full=Cytochrome P450 5A1 [Rattus norvegicus]

Related Sequences to LMP012445 proteins

Reference Database Accession Length Protein Name
GI:6981634 DBBJ BAA05962.1 533 thromboxane synthase [Rattus norvegicus]
GI:6981634 GenBank EDM15371.1 533 thromboxane A synthase 1 [Rattus norvegicus]
GI:6981634 SwissProt P49430.1 533 RecName: Full=Thromboxane-A synthase; Short=TXA synthase; Short=TXS; AltName: Full=Cytochrome P450 5A1 [Rattus norvegicus]