Gene/Proteome Database (LMPD)

LMPD ID
LMP012441
Gene ID
24831
Species
Rattus norvegicus (Rat)
Gene Name
thyroid hormone receptor beta
Gene Symbol
Thrb
Synonyms
ERBA2; Nr1a2; T3rec; TRbeta; RATT3REC; C-erba-beta;
Alternate Names
thyroid hormone receptor beta; c-erbA-2; TRbeta2Delta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; nuclear receptor subfamily 1 group A member 2; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2);
Chromosome
15
Map Location
15p16
Summary
nuclear hormone receptor for triiodothyronine (T3); mediates the biological activities of thyroid hormone [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Thrb

Proteins

thyroid hormone receptor beta isoform 1
Refseq ID NP_036804
Protein GI 145386519
UniProt ID Q3HW36
mRNA ID NM_012672
Length 497
MTPNSMTENGLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKPSHTRDEKTGIWFHTDTSSTSLHSVWMLSSRQWDPEGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
thyroid hormone receptor beta isoform 2
Refseq ID NP_001257783
Protein GI 399498506
mRNA ID NM_001270854
Length 461
MTPNSMTENGLPAWDKQKPHPDRGQDWKLVGMSEACLHRKSHVERRGALKNEQTSSHLIQATWASSIFHLDPDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKSLHPSYSCKYEGKCIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED

Gene Information

Entrez Gene ID
24831
Gene Name
thyroid hormone receptor beta
Gene Symbol
Thrb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0004887 IEA:InterPro F thyroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
rno04919 Thyroid hormone signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
thyroid hormone receptor beta
Species
Rat

Comments

Comment Type Description
Similarity Belongs to the nuclear hormone receptor family
Similarity Contains nuclear receptor DNA-binding domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012441 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145386519 RefSeq NP_036804 497 thyroid hormone receptor beta isoform 1
399498506 RefSeq NP_001257783 461 thyroid hormone receptor beta isoform 2

Identical Sequences to LMP012441 proteins

Reference Database Accession Length Protein Name
GI:145386519 GenBank ABA39294.1 497 thyroid hormone receptor beta delta variant [Rattus norvegicus]
GI:399498506 GenBank EDL94088.1 461 thyroid hormone receptor beta, isoform CRA_b [Rattus norvegicus]
GI:399498506 GenBank EDL94089.1 461 thyroid hormone receptor beta, isoform CRA_b [Rattus norvegicus]
GI:399498506 RefSeq XP_008768722.1 461 PREDICTED: thyroid hormone receptor beta isoform X1 [Rattus norvegicus]

Related Sequences to LMP012441 proteins

Reference Database Accession Length Protein Name
GI:145386519 GenBank ABA39294.1 497 thyroid hormone receptor beta delta variant [Rattus norvegicus]
GI:399498506 GenBank EDL94088.1 461 thyroid hormone receptor beta, isoform CRA_b [Rattus norvegicus]
GI:145386519 GenBank EDL94089.1 461 thyroid hormone receptor beta, isoform CRA_b [Rattus norvegicus]
GI:399498506 GenBank EDL94089.1 461 thyroid hormone receptor beta, isoform CRA_b [Rattus norvegicus]
GI:145386519 RefSeq XP_008768722.1 461 PREDICTED: thyroid hormone receptor beta isoform X1 [Rattus norvegicus]
GI:399498506 RefSeq XP_008768722.1 461 PREDICTED: thyroid hormone receptor beta isoform X1 [Rattus norvegicus]