Gene/Proteome Database (LMPD)

LMPD ID
LMP012394
Gene ID
24242
Species
Rattus norvegicus (Rat)
Gene Name
calmodulin 1
Gene Symbol
Calm1
Synonyms
CaMI;
Alternate Names
calmodulin; caM; Calmodulin 1 (phosphorylase kinase, delta);
Chromosome
6
Map Location
6q31-q32
Summary
may mediate calcium-dependent modulation of KCNQ channels; exists in two alternative splice forms [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Calm1

Proteins

calmodulin
Refseq ID NP_114175
Protein GI 14010863
UniProt ID P62161
mRNA ID NM_031969
Length 149
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Gene Information

Entrez Gene ID
24242
Gene Name
calmodulin 1
Gene Symbol
Calm1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0034704 IEA:Ensembl C calcium channel complex
GO:0005813 IEA:Ensembl C centrosome
GO:0005737 IDA:RGD C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0030426 IDA:RGD C growth cone
GO:0043005 IDA:RGD C neuron projection
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:RGD C nucleus
GO:0005886 IDA:RGD C plasma membrane
GO:0030017 IEA:Ensembl C sarcomere
GO:0005876 IEA:Ensembl C spindle microtubule
GO:0000922 IEA:Ensembl C spindle pole
GO:0008179 IDA:RGD F adenylate cyclase binding
GO:0005246 NAS:RGD F calcium channel regulator activity
GO:0005509 IDA:RGD F calcium ion binding
GO:0048306 IPI:RGD F calcium-dependent protein binding
GO:0030234 IMP:RGD F enzyme regulator activity
GO:0044325 IDA:RGD F ion channel binding
GO:0050998 IDA:RGD F nitric-oxide synthase binding
GO:0030235 IDA:RGD F nitric-oxide synthase regulator activity
GO:0043548 IPI:RGD F phosphatidylinositol 3-kinase binding
GO:0047485 IMP:RGD F protein N-terminus binding
GO:0019904 IPI:RGD F protein domain specific binding
GO:0072542 IEA:Ensembl F protein phosphatase activator activity
GO:0031800 IPI:RGD F type 3 metabotropic glutamate receptor binding
GO:0007190 IDA:RGD P activation of adenylate cyclase activity
GO:0019722 IMP:RGD P calcium-mediated signaling
GO:0005513 IEA:Ensembl P detection of calcium ion
GO:0051343 IEA:Ensembl P positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051000 IDA:RGD P positive regulation of nitric-oxide synthase activity
GO:0032516 IEA:Ensembl P positive regulation of phosphoprotein phosphatase activity
GO:0035307 IEA:Ensembl P positive regulation of protein dephosphorylation
GO:0060316 IEA:Ensembl P positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0055117 IEA:Ensembl P regulation of cardiac muscle contraction
GO:0032465 IEA:Ensembl P regulation of cytokinesis
GO:0002027 IEA:Ensembl P regulation of heart rate
GO:1901841 IMP:RGD P regulation of high voltage-gated calcium channel activity
GO:0010880 IEA:Ensembl P regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0060314 IDA:RGD P regulation of ryanodine-sensitive calcium-release channel activity
GO:1901339 IC:RGD P regulation of store-operated calcium channel activity
GO:0001975 IEP:RGD P response to amphetamine
GO:0051412 IEP:RGD P response to corticosterone
GO:0021762 IEA:Ensembl P substantia nigra development

KEGG Pathway Links

KEGG Pathway ID Description
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko05034 Alcoholism
rno05034 Alcoholism
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease
ko05031 Amphetamine addiction
rno05031 Amphetamine addiction
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04713 Circadian entrainment
rno04713 Circadian entrainment
ko04728 Dopaminergic synapse
rno04728 Dopaminergic synapse
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04971 Gastric acid secretion
rno04971 Gastric acid secretion
ko05214 Glioma
rno05214 Glioma
ko04912 GnRH signaling pathway
rno04912 GnRH signaling pathway
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
ko04720 Long-term potentiation
rno04720 Long-term potentiation
ko04916 Melanogenesis
rno04916 Melanogenesis
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
ko04740 Olfactory transduction
rno04740 Olfactory transduction
ko04114 Oocyte meiosis
rno04114 Oocyte meiosis
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko05133 Pertussis
rno05133 Pertussis
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04744 Phototransduction
rno04744 Phototransduction
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04970 Salivary secretion
rno04970 Salivary secretion
ko05152 Tuberculosis
rno05152 Tuberculosis
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954317 Activation of Ca-permeable Kainate Receptor
5953602 Activation of CaMK IV
5954319 Activation of Kainate Receptors upon glutamate binding
5953605 Activation of NMDA receptor upon glutamate binding and postsynaptic events
5953415 Adaptive Immune System
5953413 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5954296 CREB phosphorylation through the activation of CaMKII
5953603 CREB phosphorylation through the activation of CaMKK
5954295 CREB phosphorylation through the activation of Ras
5953387 Ca-dependent events
5953801 Ca2+ pathway
5953386 CaM pathway
5953597 CaMK IV-mediated phosphorylation of CREB
5953598 Calmodulin induced events
5953615 Cam-PDE 1 activation
5953392 DAG and IP3 signaling
5953408 DAP12 interactions
5953407 DAP12 signaling
5953612 DARPP-32 events
5953253 Disease
5953382 Diseases associated with visual transduction
5953396 Downstream signal transduction
5953399 Downstream signaling of activated FGFR
5953402 EGFR interacts with phospholipase C-gamma
5953416 FCERI mediated Ca+2 mobilization
5953417 Fc epsilon receptor (FCERI) signaling
5953389 G-protein mediated events
5953248 Glucose metabolism
5953266 Glycogen breakdown (glycogenolysis)
5953252 Glycogen storage diseases
5953645 Hemostasis
5953410 Immune System
5953378 Inactivation, recovery and regulation of the phototransduction cascade
5953409 Innate Immune System
5954515 Inositol phosphate metabolism
5954318 Ionotropic activity of Kainate Receptors
5953916 Membrane Trafficking
5953250 Metabolism
5953249 Metabolism of carbohydrates
5954034 Metabolism of nitric oxide
5953600 Mitochondrial biogenesis
5953412 Muscle contraction
5953251 Myoclonic epilepsy of Lafora
5953394 NGF signalling via TRKA from the plasma membrane
5953277 Neuronal System
5953606 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
5953390 Opioid Signalling
5953601 Organelle biogenesis and maintenance
5953388 PLC beta mediated events
5953393 PLC-gamma1 signalling
5953405 PLCG1 events in ERBB2 signaling
5953398 Phospholipase C-mediated cascade
5953644 Platelet activation, signaling and aggregation
5954102 Platelet degranulation
5953604 Post NMDA receptor activation events
5954297 Ras activation uopn Ca2+ infux through NMDA receptor
5953646 Response to elevated platelet cytosolic Ca2+
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5953391 Signaling by GPCR
5953397 Signaling by PDGF
5953420 Signaling by VEGF
5953803 Signaling by Wnt
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF
5953411 Smooth Muscle Contraction
5954514 Synthesis of IP3 and IP4 in the cytosol
5954461 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
5953379 The phototransduction cascade
5953599 Transcriptional activation of mitochondrial biogenesis
5954455 Translocation of GLUT4 to the plasma membrane
5953276 Transmission across Chemical Synapses
5953419 VEGFA-VEGFR2 Pathway
5953418 VEGFR2 mediated cell proliferation
5953999 VEGFR2 mediated vascular permeability
5953380 Visual phototransduction
5953802 beta-catenin independent WNT signaling
5954032 eNOS activation
5954033 eNOS activation and regulation

Domain Information

InterPro Annotations

Accession Description
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair

UniProt Annotations

Entry Information

Gene Name
calmodulin 1
Protein Entry
CALM_RAT
UniProt ID
P62161
Species
Rat

Comments

Comment Type Description
Function Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity)
Interaction P00533:EGFR (xeno); NbExp=6; IntAct=EBI-397530, EBI-297353; Q14451:GRB7 (xeno); NbExp=9; IntAct=EBI-397530, EBI-970191; P23711:Hmox2; NbExp=2; IntAct=EBI-397530, EBI-2910092; P70604:Kcnn2; NbExp=2; IntAct=EBI-397530, EBI-1031103; O88943:Kcnq2; NbExp=4; IntAct=EBI-397530, EBI-7900557; P38377:SEC61A1 (xeno); NbExp=4; IntAct=EBI-397530, EBI-8517797; P52888:THOP1 (xeno); NbExp=2; IntAct=EBI-397530, EBI-372399; P24155:Thop1; NbExp=2; IntAct=EBI-397530, EBI-6372841;
Miscellaneous This protein has four functional calcium-binding sites.
Ptm Phosphorylation results in a decreased activity
Ptm Ubiquitination results in a strongly decreased activity
Similarity Belongs to the calmodulin family
Similarity Contains 4 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules
Subunit Interacts with CEP97, CCP110, MYO1C, TTN/titin and SRY. Interacts with MYO10 and MYO5A. Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with RRAD. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport. {ECO:0000250, ECO:0000269|PubMed:18056528, ECO:0000269|PubMed:23109337}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012394 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14010863 RefSeq NP_114175 149 calmodulin

Identical Sequences to LMP012394 proteins

Reference Database Accession Length Protein Name
GI:14010863 RefSeq XP_010639153.1 149 PREDICTED: calmodulin [Fukomys damarensis]
GI:14010863 RefSeq XP_010614093.1 149 PREDICTED: calmodulin [Fukomys damarensis]
GI:14010863 RefSeq XP_010614598.1 149 PREDICTED: calmodulin [Fukomys damarensis]
GI:14010863 RefSeq XP_010595577.1 149 PREDICTED: calmodulin [Loxodonta africana]

Related Sequences to LMP012394 proteins

Reference Database Accession Length Protein Name
GI:14010863 GenBank JAB54564.1 149 Calmodulin-4 [Micrurus fulvius]
GI:14010863 GenBank JAB54566.1 149 Calmodulin [Micrurus fulvius]
GI:14010863 RefSeq NP_001133186.1 149 calmodulin 2 (phosphorylase kinase, delta)-3 [Salmo salar]