Gene/Proteome Database (LMPD)
LMPD ID
LMP012390
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 1 family, member A1
Gene Symbol
Synonyms
Ahd2; Aldh1; Aldh2;
Alternate Names
retinal dehydrogenase 1; ALHDII; ralDH1; ALDH-E1; RALDH 1; aldehyde dehydrogenase 2; aldehyde dehydrogenase 1A1; aldehyde dehydrogenase, cytosolic; aldehyde dehydrogenase 1, subfamily A1; aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, member A1; aldehyde dehydrogenase family 1, subfamily A1;
Chromosome
1
Map Location
1q51
EC Number
1.2.1.36
Summary
ubiquitous enzyme located in virtually all mammalian tissues; catalyzes oxidation of aldehyde substrates to carboxylic acids; detoxifies ethanol-derived acetaldehyde [RGD, Feb 2006]
Orthologs
Proteins
| retinal dehydrogenase 1 | |
|---|---|
| Refseq ID | NP_071852 |
| Protein GI | 14192935 |
| UniProt ID | P51647 |
| mRNA ID | NM_022407 |
| Length | 501 |
| MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS | |
Gene Information
Entrez Gene ID
Gene Name
aldehyde dehydrogenase 1 family, member A1
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:RGD | C | cytoplasm |
| GO:0005634 | IDA:RGD | C | nucleus |
| GO:0004028 | TAS:RGD | F | 3-chloroallyl aldehyde dehydrogenase activity |
| GO:0004029 | IDA:RGD | F | aldehyde dehydrogenase (NAD) activity |
| GO:0018479 | IDA:RGD | F | benzaldehyde dehydrogenase (NAD+) activity |
| GO:0042802 | IDA:RGD | F | identical protein binding |
| GO:0001758 | IDA:RGD | F | retinal dehydrogenase activity |
| GO:0042904 | IEA:Ensembl | P | 9-cis-retinoic acid biosynthetic process |
| GO:0042905 | IDA:RGD | P | 9-cis-retinoic acid metabolic process |
| GO:0060206 | IEP:RGD | P | estrous cycle phase |
| GO:0001822 | IEP:RGD | P | kidney development |
| GO:0001889 | IEP:RGD | P | liver development |
| GO:0007494 | IEP:RGD | P | midgut development |
| GO:0002072 | IEA:Ensembl | P | optic cup morphogenesis involved in camera-type eye development |
| GO:0043065 | IEA:Ensembl | P | positive regulation of apoptotic process |
| GO:0051289 | IDA:RGD | P | protein homotetramerization |
| GO:0042493 | IEP:RGD | P | response to drug |
| GO:0032355 | IEP:RGD | P | response to estradiol |
| GO:0045471 | IDA:RGD | P | response to ethanol |
| GO:0014070 | IEP:RGD | P | response to organic cyclic compound |
| GO:0006979 | IMP:RGD | P | response to oxidative stress |
| GO:0032526 | IEP:RGD | P | response to retinoic acid |
| GO:0002138 | IMP:RGD | P | retinoic acid biosynthetic process |
| GO:0042572 | IEA:UniProtKB-UniPathway | P | retinol metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| rno01100 | Metabolic pathways |
| ko00830 | Retinol metabolism |
| rno00830 | Retinol metabolism |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016162 | Aldehyde dehydrogenase N-terminal domain |
| IPR015590 | Aldehyde dehydrogenase domain |
| IPR016163 | Aldehyde dehydrogenase, C-terminal |
| IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| IPR016161 | Aldehyde/histidinol dehydrogenase |
UniProt Annotations
Entry Information
Gene Name
aldehyde dehydrogenase 1 family, member A1
Protein Entry
AL1A1_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Retinal + NAD(+) + H(2)O = retinoate + NADH. |
| Enzyme Regulation | Inhibited by chloral hydrate. |
| Function | Is capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal. |
| Pathway | Cofactor metabolism; retinol metabolism. |
| Ptm | The N-terminus is blocked. |
| Similarity | Belongs to the aldehyde dehydrogenase family |
| Subcellular Location | Cytoplasm. |
| Subunit | Homotetramer |
| Tissue Specificity | Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012390 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 14192935 | RefSeq | NP_071852 | 501 | retinal dehydrogenase 1 |
Identical Sequences to LMP012390 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14192935 | GenBank | AAH61526.1 | 501 | Aldehyde dehydrogenase 1 family, member A1 [Rattus norvegicus] |
| GI:14192935 | GenBank | EDM12994.1 | 501 | rCG47846 [Rattus norvegicus] |
| GI:14192935 | GenBank | AEK13597.1 | 501 | Sequence 9 from patent US 7972785 |
| GI:14192935 | SwissProt | P51647.3 | 501 | RecName: Full=Retinal dehydrogenase 1; Short=RALDH 1; Short=RalDH1; AltName: Full=ALDH-E1; AltName: Full=ALHDII; AltName: Full=Aldehyde dehydrogenase family 1 member A1; AltName: Full=Aldehyde dehydrogenase, cytosolic [Rattus norvegicus] |
Related Sequences to LMP012390 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:14192935 | GenBank | AAC53304.1 | 501 | aldehyde dehydrogenase [Rattus norvegicus] |
| GI:14192935 | GenBank | AAC53305.1 | 501 | aldehyde dehydrogenase [Rattus norvegicus] |
| GI:14192935 | GenBank | AAC53306.1 | 501 | aldehyde dehydrogenase [Rattus norvegicus] |