Gene/Proteome Database (LMPD)

LMPD ID
LMP012387
Gene ID
24161
Species
Rattus norvegicus (Rat)
Gene Name
acid phosphatase 1, soluble
Gene Symbol
Acp1
Alternate Names
low molecular weight phosphotyrosine protein phosphatase; LMW-PTPase; low molecular weight cytosolic acid phosphatase; LMW-PTP-I low molecular weight phosphotyrosine protein phosphatase isozyme 1;
Chromosome
6
Map Location
6q16
EC Number
3.1.3.48
Summary
catalyzes the hydrolysis of p-nitrophenyl phosphate; may play a role in synaptic transmission [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acp1

Proteins

low molecular weight phosphotyrosine protein phosphatase isoform A
Refseq ID NP_067085
Protein GI 10863989
UniProt ID P41498
mRNA ID NM_021262
Length 158
MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDENVSDNWRIDSAATSTYEVGNPPDYRGQNCMKKHGIHMQHIARQITREDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTH
low molecular weight phosphotyrosine protein phosphatase isoform B
Refseq ID NP_001129034
Protein GI 207113137
UniProt ID B0BNC1
mRNA ID NM_001135562
Length 158
MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDENVSDNWAIDSSAVSDWNVGRPPDPRAVSCLRNHGISTAHKARQITREDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTH

Gene Information

Entrez Gene ID
24161
Gene Name
acid phosphatase 1, soluble
Gene Symbol
Acp1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0043005 IDA:RGD C neuron projection
GO:0017124 IDA:RGD F SH3 domain binding
GO:0003993 IDA:RGD F acid phosphatase activity
GO:0004726 IEA:InterPro F non-membrane spanning protein tyrosine phosphatase activity
GO:0004725 IDA:RGD F protein tyrosine phosphatase activity
GO:0035335 IDA:GOC P peptidyl-tyrosine dephosphorylation
GO:0007268 IEP:RGD P synaptic transmission

KEGG Pathway Links

KEGG Pathway ID Description
ko04520 Adherens junction
rno04520 Adherens junction
ko00740 Riboflavin metabolism
rno00740 Riboflavin metabolism

Domain Information

InterPro Annotations

Accession Description
IPR023485 Ptyr_pPase_SF
IPR002115 Tyr_Pase_low_mol_wt_mml
IPR000106 Tyr_phospatase/Ars_reductase
IPR017867 Tyr_phospatase_low_mol_wt

UniProt Annotations

Entry Information

Gene Name
acid phosphatase 1, soluble
Protein Entry
PPAC_RAT
UniProt ID
P41498
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=ACP1, A; IsoId=P41498-1; Sequence=Displayed; Name=2; Synonyms=ACP2, B; IsoId=P41498-2; Sequence=VSP_004705;
Catalytic Activity A phosphate monoester + H(2)O = an alcohol + phosphate.
Catalytic Activity Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Function Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
Similarity Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Subcellular Location Cytoplasm.
Subunit Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1 (By similarity). Isoform 1 interacts with the SH3 domain of SPTAN1

Identical and Related Proteins

Unique RefSeq proteins for LMP012387 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
10863989 RefSeq NP_067085 158 low molecular weight phosphotyrosine protein phosphatase isoform A
207113137 RefSeq NP_001129034 158 low molecular weight phosphotyrosine protein phosphatase isoform B

Identical Sequences to LMP012387 proteins

Reference Database Accession Length Protein Name
GI:10863989 GenBank AAD50990.1 158 low molecular weight protein tyrosine phosphatase isoform A [Rattus norvegicus]
GI:10863989 GenBank AAH62229.1 158 Acid phosphatase 1, soluble [Rattus norvegicus]
GI:207113137 GenBank EDM03241.1 158 rCG61973, isoform CRA_b [Rattus norvegicus]
GI:10863989 GenBank EDM03242.1 158 rCG61973, isoform CRA_c [Rattus norvegicus]
GI:207113137 GenBank AAI58764.1 158 Acp1 protein [Rattus norvegicus]
GI:207113137 GenBank AAI61990.1 158 Acp1 protein [Rattus norvegicus]
GI:10863989 SwissProt P41498.3 158 RecName: Full=Low molecular weight phosphotyrosine protein phosphatase; Short=LMW-PTP; Short=LMW-PTPase; AltName: Full=Low molecular weight cytosolic acid phosphatase [Rattus norvegicus]

Related Sequences to LMP012387 proteins

Reference Database Accession Length Protein Name
GI:10863989 GenBank AAD50990.1 158 low molecular weight protein tyrosine phosphatase isoform A [Rattus norvegicus]
GI:207113137 GenBank EDM03241.1 158 rCG61973, isoform CRA_b [Rattus norvegicus]
GI:10863989 GenBank EDM03242.1 158 rCG61973, isoform CRA_c [Rattus norvegicus]
GI:207113137 GenBank AAI58764.1 158 Acp1 protein [Rattus norvegicus]
GI:207113137 GenBank AAI61990.1 158 Acp1 protein [Rattus norvegicus]
GI:10863989 SwissProt P41498.3 158 RecName: Full=Low molecular weight phosphotyrosine protein phosphatase; Short=LMW-PTP; Short=LMW-PTPase; AltName: Full=Low molecular weight cytosolic acid phosphatase [Rattus norvegicus]