Gene/Proteome Database (LMPD)

LMPD ID
LMP012385
Gene ID
24157
Species
Rattus norvegicus (Rat)
Gene Name
acetyl-CoA acyltransferase 1
Gene Symbol
Acaa1a
Synonyms
Acaa; Acaa1; Pktaa;
Alternate Names
3-ketoacyl-CoA thiolase A, peroxisomal; beta-ketothiolase A; acetyl-CoA acyltransferase A; acetyl-CoA acyltransferase 1A; acetyl-Coenzyme A acyltransferase 1A; peroxisomal 3-oxoacyl-CoA thiolase A; acetyl-CoA acyltransferase, 3-oxo acyl-CoA thiolase A; Acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A peroxisomal; acetyl-CoA acyltransferase 3-oxo acyl-CoA thiolase A 1 peroxisomal; acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase);
Chromosome
8
Map Location
8q32
EC Number
2.3.1.16
Summary
peroxisomal 3-ketoacyl-CoA thiolase; involved in beta-oxidation of fatty acids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acaa1a

Proteins

3-ketoacyl-CoA thiolase A, peroxisomal
Refseq ID NP_036621
Protein GI 6978429
UniProt ID P21775
mRNA ID NM_012489
Length 434
MSESVGRTSAMHRLQVVLGHLAGRPESSSALQAAPCSATFPQASASDVVVVHGRRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKLKPECLGDISVGNVLEPGAGAVMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMSLSNRGNPGNISSRLLESDKARDCLIPMGITSENVAERFGISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQALYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGTRAYGVVSMCIGTGMGAAAVFEYPGN

Gene Information

Entrez Gene ID
24157
Gene Name
acetyl-CoA acyltransferase 1
Gene Symbol
Acaa1a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:HGNC C peroxisome
GO:0003988 IEA:UniProtKB-EC F acetyl-CoA C-acyltransferase activity
GO:0016401 IGI:UniProtKB F palmitoyl-CoA oxidase activity
GO:0006635 IGI:UniProtKB P fatty acid beta-oxidation
GO:0042493 IEP:RGD P response to drug
GO:0007584 IDA:RGD P response to nutrient
GO:0048545 IDA:RGD P response to steroid hormone

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko04146 Peroxisome
rno04146 Peroxisome
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism
M00087 beta-Oxidation

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA acyltransferase 1
Protein Entry
THIKA_RAT
UniProt ID
P21775
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P21775-1; Sequence=Displayed; Name=2; IsoId=P21775-2; Sequence=VSP_023746; Note=No experimental confirmation available.;
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Induction Peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system.
Pathway Lipid metabolism; fatty acid metabolism.
Sequence Caution Sequence=AAA41471.1; Type=Erroneous initiation; Evidence= ; Sequence=AAH89821.1; Type=Erroneous initiation; Evidence= ; Sequence=BAA14106.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the thiolase family
Subcellular Location Peroxisome.
Subunit Homodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP012385 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6978429 RefSeq NP_036621 434 3-ketoacyl-CoA thiolase A, peroxisomal

Identical Sequences to LMP012385 proteins

Reference Database Accession Length Protein Name
GI:6978429 GenBank AAA41471.1 434 3-ketoacyl-CoA thiolase 2 (EC 2.3.1.16) [Rattus norvegicus]

Related Sequences to LMP012385 proteins

Reference Database Accession Length Protein Name
GI:6978429 DBBJ BAA14106.1 434 peroxisomal 3-ketoacyl-CoA thiolase A [Rattus norvegicus]
GI:6978429 GenBank AAA41471.1 434 3-ketoacyl-CoA thiolase 2 (EC 2.3.1.16) [Rattus norvegicus]
GI:6978429 GenBank EDL76916.1 434 rCG25819, isoform CRA_a [Rattus norvegicus]