Gene/Proteome Database (LMPD)

LMPD ID
LMP012362
Gene ID
91734
Species
Homo sapiens (Human)
Gene Name
isopentenyl-diphosphate delta isomerase 2
Gene Symbol
IDI2
Synonyms
IPPI2;
Chromosome
10
Map Location
10p15.3
EC Number
5.3.3.2

Proteins

isopentenyl-diphosphate delta-isomerase 2
Refseq ID NP_150286
Protein GI 15147242
UniProt ID Q9BXS1
mRNA ID NM_033261
Length 227
MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFNTKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV

Gene Information

Entrez Gene ID
91734
Gene Name
isopentenyl-diphosphate delta isomerase 2
Gene Symbol
IDI2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005777 IDA:UniProtKB C peroxisome
GO:0016787 IEA:InterPro F hydrolase activity
GO:0004452 IDA:UniProtKB F isopentenyl-diphosphate delta-isomerase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006695 TAS:Reactome P cholesterol biosynthetic process
GO:0050992 IEA:UniProtKB-UniPathway P dimethylallyl diphosphate biosynthetic process
GO:0046490 IDA:MGI P isopentenyl diphosphate metabolic process
GO:0008299 IDA:UniProtKB P isoprenoid biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
hsa01100 Metabolic pathways
hsa00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-922 mevalonate pathway I
PWY-922 mevalonate pathway I
PWY66-5 superpathway of cholesterol biosynthesis
PWY66-5 superpathway of cholesterol biosynthesis
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
PWY-5123 trans, trans-farnesyl diphosphate biosynthesis
PWY-5123 trans, trans-farnesyl diphosphate biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_9405 Cholesterol biosynthesis
REACT_111217 Metabolism
REACT_22258 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1
IPR000086 NUDIX hydrolase domain
IPR015797 NUDIX hydrolase domain-like

UniProt Annotations

Entry Information

Gene Name
isopentenyl-diphosphate delta isomerase 2
UniProt ID
Q9BXS1
Species
Human

Comments

Comment Type Description
Catalytic Activity Isopentenyl diphosphate = dimethylallyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 1 Mg(2+) ion per subunit. ;
Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Pathway Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Similarity Belongs to the IPP isomerase type 1 family
Similarity Contains 1 nudix hydrolase domain
Subcellular Location Peroxisome
Tissue Specificity Detected in skeletal muscle

Identical and Related Proteins

Unique RefSeq proteins for LMP012362 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15147242 RefSeq NP_150286 227 isopentenyl-diphosphate delta-isomerase 2

Identical Sequences to LMP012362 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012362 proteins

Reference Database Accession Length Protein Name