Gene/Proteome Database (LMPD)

LMPD ID
LMP012321
Gene ID
100101649
Species
Danio rerio (Zebrafish)
Gene Name
APC membrane recruitment protein 2
Gene Symbol
amer2
Synonyms
fam123a; zgc:165647
Alternate Names
APC membrane recruitment protein 2; family with sequence similarity 123A
Chromosome
24

Proteins

APC membrane recruitment protein 2
Refseq ID NP_001093622
Protein GI 153945882
UniProt ID F1QGH6
mRNA ID NM_001100152
Length 654
RefSeq Status PROVISIONAL
MEVQTECSEPPPCDPQPPGKLNKAAFKLFGKRKSGSSMPSIFSVRNKGESTGKAAGKTLELVRSKTHDGLITDTPSELDSHRKEGSASSDQLHAGTPDGVSTAPLRSSITKSFSFFSLLRRSSSRAGDGTTTVGRRGRGLKGLFSSMRWRRKPQIQEDTLEVAKEVKEGDLILSSSSGSVKTEKDMTLTLEPLPQVFEESPLPGDSDKWKVASMQEIQGTNEVECGNCGPSVSQQHTVTEESPAPSPLRVQTGGFQNHKHSSSTHLSSIPTCALTPPMEHSTADPQSEQSVDRLCSMFTDVTSLKSFDSLTGCGDIIADPEEDSGNGGSATSSGTGSSSGGCMGRRLSGAGTNSERCSPAKPPLPPQVSSLASIHASCYMPAHQRPRAAPKKPQGSGVVAYMGGGEEMASPEGVDDADMQGLWHMLPQKDEDSPAPRRAEPVLHHAPARLEKRPPQVKALGLSKIPVSGSSKTGKQQPSRPSPPPVDKELQDAPPSDEGYWDSPTPGPEDEDSTFLRRDGLLRDSCSGDALYDLYDPDSPSAAGSDDDASSPTKSAGDLKMNLPSPKCSSSATSSFRSMKGNTSLPRDSKIPISVRQTPPSHSSSQGALSSNLSPTSTTPPKKTDAPPRTKIPVSKVPVRRSGGKSTSTSQSRK

Gene Information

Entrez Gene ID
100101649
Gene Name
APC membrane recruitment protein 2
Gene Symbol
amer2
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0005546 ISS:UniProtKB F phosphatidylinositol-4,5-bisphosphate binding
GO:0016055 IEA:UniProtKB-KW P Wnt signaling pathway
GO:0007398 ISS:UniProtKB P ectoderm development
GO:0090090 ISS:UniProtKB P negative regulation of canonical Wnt signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR019003 Uncharacterised protein family FAM123

UniProt Annotations

Entry Information

Gene Name
APC membrane recruitment protein 2
Protein Entry
AMER2_DANRE
UniProt ID
F1QGH6
Species
Zebrafish

Comments

Comment Type Description
Function Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). {ECO:0000250}.
Similarity Belongs to the Amer family. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012321 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
153945882 RefSeq NP_001093622 654 APC membrane recruitment protein 2

Identical Sequences to LMP012321 proteins

Reference Database Accession Length Protein Name
GI:153945882 GenBank AAI46747.1 654 Zgc:165647 protein [Danio rerio]

Related Sequences to LMP012321 proteins

Reference Database Accession Length Protein Name
GI:153945882 RefSeq XP_005471779.1 691 PREDICTED: APC membrane recruitment protein 2-like [Oreochromis niloticus]
GI:153945882 RefSeq XP_005722526.1 691 PREDICTED: APC membrane recruitment protein 2-like [Pundamilia nyererei]
GI:153945882 RefSeq XP_007252366.1 652 PREDICTED: APC membrane recruitment protein 2 [Astyanax mexicanus]
GI:153945882 RefSeq XP_008274506.1 695 PREDICTED: APC membrane recruitment protein 2 [Stegastes partitus]
GI:153945882 RefSeq XP_008305687.1 686 PREDICTED: APC membrane recruitment protein 2 [Cynoglossus semilaevis]
GI:153945882 SwissProt F1QGH6.1 654 RecName: Full=APC membrane recruitment protein 2; Short=Amer2; AltName: Full=Protein FAM123A [Danio rerio]