Gene/Proteome Database (LMPD)
Proteins
| retinoic acid receptor RXR-alpha-B | |
|---|---|
| Refseq ID | NP_571228 |
| Protein GI | 18859345 |
| UniProt ID | Q90415 |
| mRNA ID | NM_131153 |
| Length | 379 |
| RefSeq Status | PROVISIONAL |
| MPVPEQKQTVQLSSPMNAVSSSEDIKPPLGLNGVMKVPAHRIGTLSLSLTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCMIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRAKERSEAEFGGCANEDMPVEKILEAELAVEPKTETYVEANLSPSANSPNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHTAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPSEVEALRERVYASLEAYCKHKYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQIT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0004886 | ISS:UniProtKB | F | 9-cis retinoic acid receptor activity |
| GO:0043565 | IEA:InterPro | F | sequence-specific DNA binding |
| GO:0003700 | ISS:UniProtKB | F | sequence-specific DNA binding transcription factor activity |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0045944 | ISS:UniProtKB | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0048384 | IDA:GOC | P | retinoic acid receptor signaling pathway |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| IPR000003 | Retinoid X receptor/HNF4 |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Gene Name
retinoid x receptor, alpha b
Protein Entry
Q90415_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed both maternally and zygotically. {ECO:0000269|PubMed:16448862, ECO:0000269|PubMed:17195188, ECO:0000269|PubMed:17997606, ECO:0000269|PubMed:7565671}. |
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for this rxr is 9-cis retinoic acid (By similarity). |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. |
| Subcellular Location | Nucleus. |
| Subunit | Homodimer. Heterodimer; with a rar molecule. Binds DNA preferentially as a rar/rxr heterodimer. |
| Tissue Specificity | Uniform expression from the blastula to mid- gastrula stages. At 12 hours post-fertilization (hpf), expressed strongly in the tail and weakly elsewhere. At 24 hpf, weak expression in the forebrain, eyes and pharyngeal endoderm and continued expression in the tail mesoderm. At 48 hpf, anterior expression limited to ventral cells underlying the head, medial expression in the pectoral fin bud mesoderm and continued tail expression. {ECO:0000269|PubMed:16448862, ECO:0000269|PubMed:17195188}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012249 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18859345 | RefSeq | NP_571228 | 379 | retinoic acid receptor RXR-alpha-B |
Identical Sequences to LMP012249 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18859345 | GenBank | AAC59719.1 | 379 | retinoid X receptor [Danio rerio] |
| GI:18859345 | SwissProt | Q90415.1 | 379 | RecName: Full=Retinoic acid receptor RXR-alpha-B; AltName: Full=Nuclear receptor subfamily 2 group B member 1-B; AltName: Full=Retinoid X receptor alpha-B [Danio rerio] |
Related Sequences to LMP012249 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18859345 | PRF | - | 391 | retinoid X receptor:ISOTYPE=gamma [Danio rerio] |
| GI:18859345 | RefSeq | XP_001506054.1 | 433 | PREDICTED: retinoic acid receptor RXR-alpha isoform X2 [Ornithorhynchus anatinus] |
| GI:18859345 | RefSeq | NP_001155023.1 | 458 | retinoic acid receptor RXR-alpha-A [Danio rerio] |
| GI:18859345 | RefSeq | XP_003757522.1 | 468 | PREDICTED: retinoic acid receptor RXR-alpha [Sarcophilus harrisii] |
| GI:18859345 | RefSeq | XP_005161241.1 | 495 | PREDICTED: retinoic acid receptor RXR-alpha-A isoform X2 [Danio rerio] |
| GI:18859345 | RefSeq | XP_009300230.1 | 494 | PREDICTED: retinoic acid receptor RXR-alpha-B isoform X1 [Danio rerio] |