Gene/Proteome Database (LMPD)

LMPD ID
LMP012200
Gene ID
751641
Species
Danio rerio (Zebrafish)
Gene Name
cytochrome b5 reductase 2
Gene Symbol
cyb5r2
Synonyms
im:7147295; zgc:153291
Alternate Names
NADH-cytochrome b5 reductase 2; b5R.2
Chromosome
25
EC Number
1.6.2.2

Proteins

NADH-cytochrome b5 reductase 2
Refseq ID NP_001038825
Protein GI 113679449
UniProt ID Q0P487
mRNA ID NM_001045360
Length 309
RefSeq Status PROVISIONAL
MDILTAPVLIGVSIVVITVLYLFLKPAGSNSTPPKPQNKIPKALQDPSVKYPLPLIEKEEINHDTKRFRFGLPSSSHVLGLPIGQHIYLSAKVNGSLVVRAYTPVSSDQDQGYVDLVVKVYYKNTHPSYPDGGKMSQYLDNMKIGDTIDFRGPNGLLVYNGKGKFAIRPDKKSEAEVRKFKHVAMIAGGTGITPMLQLVRSITADSSDETVCSLIFANQTEKDILLRNELDEVHRNHPSKLKLWYTLDRPSEGWKYSEGFVNAAMMKDHLPPADSDVLVVMCGPPAMIEKACLPNLLKLGYKKENIFAY

Gene Information

Entrez Gene ID
751641
Gene Name
cytochrome b5 reductase 2
Gene Symbol
cyb5r2
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004128 IEA:UniProtKB-EC F cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0001878 IDA:ZFIN P response to yeast
GO:0016126 IEA:UniProtKB-KW P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
dre00520 Amino sugar and nucleotide sugar metabolism
ko00520 Amino sugar and nucleotide sugar metabolism

Domain Information

InterPro Annotations

Accession Description
IPR017927 Ferredoxin reductase-type FAD-binding domain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel

UniProt Annotations

Entry Information

Gene Name
cytochrome b5 reductase 2
Protein Entry
NB5R2_DANRE
UniProt ID
Q0P487
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis and drug metabolism. {ECO:0000250}.
Similarity Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. {ECO:0000305}.
Similarity Contains 1 FAD-binding FR-type domain. {ECO:0000255|PROSITE-ProRule:PRU00716}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012200 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
113679449 RefSeq NP_001038825 309 NADH-cytochrome b5 reductase 2

Identical Sequences to LMP012200 proteins

Reference Database Accession Length Protein Name
GI:113679449 GenBank AAI22222.1 309 Zgc:153291 [Danio rerio]

Related Sequences to LMP012200 proteins

Reference Database Accession Length Protein Name
GI:113679449 EMBL CDQ61614.1 302 unnamed protein product [Oncorhynchus mykiss]
GI:113679449 RefSeq XP_005928443.1 304 PREDICTED: NADH-cytochrome b5 reductase 2-like [Haplochromis burtoni]
GI:113679449 RefSeq XP_006804840.1 304 PREDICTED: NADH-cytochrome b5 reductase 2-like [Neolamprologus brichardi]
GI:113679449 RefSeq XP_007228392.1 308 PREDICTED: NADH-cytochrome b5 reductase 2-like [Astyanax mexicanus]
GI:113679449 RefSeq XP_008303460.1 303 PREDICTED: NADH-cytochrome b5 reductase 2 [Stegastes partitus]
GI:113679449 SwissProt Q0P487.2 309 RecName: Full=NADH-cytochrome b5 reductase 2; Short=b5R.2 [Danio rerio]