Gene/Proteome Database (LMPD)
LMPD ID
LMP012178
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
inositol polyphosphate phosphatase-like
Gene Symbol
Synonyms
ship-2b
Alternate Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B; INPPL-1B; SH2 domain-containing inositol phosphatase 2B', "SH2 domain-containing inositol 5'-phosphatase 2B", "SH2 domain-containing inositol-5'-phosphatase 2B;,inositol polyphosphate phosphatase-like protein 1B; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2B
Chromosome
14
EC Number
3.1.3.86
Proteins
| phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B | |
|---|---|
| Refseq ID | NP_001038691 |
| Protein GI | 113680326 |
| UniProt ID | Q2I6J0 |
| mRNA ID | NM_001045226 |
| Length | 1226 |
| RefSeq Status | PROVISIONAL |
| MTGAPWYHRDISRVRAEELLAHAGIDGSFLVRDSESVPGAYALCLLFQRHVHTYRILPDADGLLAVQATQGVQVNCFRTLGDLVLGYQNPNKGLVAPLLYPVMRESEANDESSDGDDEKPGSTFANSPPRAISPTATSPPSSSAAPHLLLQRLQELSPNSVGCEIVSLLDEYLHGNVCKDLENLKGGASGLQHFQGILSHICDSLHSEIDQTLSSLETLAKVFDHPSGHLTFSTMQNIGKSPEENMDNLLQKLTTLCNLLSSLEKRVLKALQEAVANHNLSLQPATPPESSRAPKKLARPNPVHSFQVKVVRYGRQTVSVDINEGVLLFDKKSGSFGVETVTLDRIVQLVKFQRGPAKLKMVVDSHHNPPRELVFESTKKREAFCRLLQLMKTTHSQKSELDVISVFVGTWNMGGTPPPGSLQSWVTCSGLGLTPDESISSLPHDIYAVGTQDNPQGEREWAEHIRATLRTSTNIDYKQVAVQSLWNIRLAVFVKPEHEARISQVNTASVKTGLGNTLGNKGAVGVSLLFNGTSMGFVNCHLTSGSDKALRRNHNFQDILRLLSLGEKQLSTFDISLRFNHLFWCGDLNYRLDLDALDILKHVSKREFEELMCADQLTRERHKRKAFFNFKEEKIMFPPTYRYERGSRDCYLWQKYKSSGVQVNGPSWCDRVLWKSYPESHVICTSYGCTDDIFTSEHSPVFATFEVGVISLFPRTESCSERASIELEAIEAIVKTSSKAKFFIEFHSRCLEEPRRSAENDSQYCEVPGFLKLGWSSKQLPKLHPVFSDLEHLRDQHLLLSVKSCDGFESYGECCVALRPTAGKLLDTFETCLTHRGEEMGSIRGRFRVYVPPDRRRIRERVYEWLSIEKDEREMMKDQLSPPSSSAFSIKAPSASYVASPNSYTNPAYFIFEEMPVFRKAEEIPSTIKESQVVCANNTVIQLPRVTGSHGHGKRSARRSDFTEIEIPGSLAPYKPSCETQSELSSAASSYQLFPGPHVPSTSPNQRHTTHSSNSSLQLQSHKNNMAPDSELSGKKLTNSYMNHSVFSRDMHKEKVRQDYQGVHQGRPVPIRNGPKLYPYVSTRVPAQCSASWIVEQPTPASGDNSLTALQIAKSLSEVDFQPADKKYPFHQMPSQQRQHGYDYGLASERNYSWEKEVSVLHGAPETVRELLSTLGLQRYTLDLSRSGWDDLDYFSGITEEELCAAGVSNPSHRRRILENLPKIWD | |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate phosphatase-like
Gene Symbol
Species
Danio rerio
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0042995 | IEA:UniProtKB-KW | C | cell projection |
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005856 | IEA:UniProtKB-KW | C | cytoskeleton |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0016787 | IEA:UniProtKB-KW | F | hydrolase activity |
| GO:0007155 | IEA:UniProtKB-KW | P | cell adhesion |
| GO:0002376 | IEA:UniProtKB-KW | P | immune system process |
| GO:0046856 | IEA:InterPro | P | phosphatidylinositol dephosphorylation |
Domain Information
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate phosphatase-like
Protein Entry
SHP2B_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 3,4,5- triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4- diphosphate + phosphate. |
| Domain | The NPXY sequence motif found in many tyrosine- phosphorylated proteins is required for the specific binding of the PID domain. {ECO:0000250}. |
| Domain | The SH2 domain interacts with tyrosine phosphorylated forms of proteins. {ECO:0000250}. |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity). {ECO:0000250}. |
| Ptm | Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli. |
| Similarity | Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase family. {ECO:0000305}. |
| Similarity | Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}. |
| Similarity | Contains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012178 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 113680326 | RefSeq | NP_001038691 | 1226 | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B |
Identical Sequences to LMP012178 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:113680326 | GenBank | ABB84852.1 | 1226 | SH2-domain-containing inositol 5-phosphatase 2b [Danio rerio] |
| GI:113680326 | SwissProt | Q2I6J0.1 | 1226 | RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B; AltName: Full=Inositol polyphosphate phosphatase-like protein 1B; Short=INPPL-1B; AltName: Full=SH2 domain-containing inositol 5'-phosphatase 2B; Short=SH2 domain-containing inositol phosphatase 2B; Short=SHIP-2B [Danio rerio] |
Related Sequences to LMP012178 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:113680326 | GenBank | AHH41716.1 | 1230 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B [Ictalurus punctatus] |
| GI:113680326 | RefSeq | NP_001034224.2 | 1226 | inositol polyphosphate phosphatase-like 1 [Danio rerio] |
| GI:113680326 | RefSeq | XP_003445212.1 | 1223 | PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like isoform X1 [Oreochromis niloticus] |
| GI:113680326 | RefSeq | XP_007254511.1 | 1255 | PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [Astyanax mexicanus] |
| GI:113680326 | RefSeq | XP_008301893.1 | 1222 | PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [Stegastes partitus] |
| GI:113680326 | RefSeq | XP_008301901.1 | 1222 | PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [Stegastes partitus] |