Gene/Proteome Database (LMPD)

LMPD ID
LMP012141
Gene ID
568288
Species
Danio rerio (Zebrafish)
Gene Name
phospholipase C, epsilon 1
Gene Symbol
plce1
Chromosome
12

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
Refseq ID NP_001155125
Protein GI 239582779
UniProt ID C5H807
mRNA ID NM_001161653
Length 2248
RefSeq Status PROVISIONAL
MRLHVERQAHIGIKSSMASNRASPVLGVKSLGKETSSNGDARLLMNYSLPGGTPPQTPVHLEGDSVGTVCRIWKSLDIRSKSLDCLDETFRSKNCSCEAIRHREEGSYNFHMCGFCDSVENAEGCPKNTFSPRSWGTVPQKRKAEAFSSGITSLDEPRPTLSGSDGELCPKELVISQNMENLPFCGLDLRRSSVPVSTPQGPQCANGCGTAENNKMRNRLDFVCAICHKNGFSSLERLNRNTKPMCSKGKPLKRSKPFRFSVPDSSDGEGTVSDSEFVRNRKDRSTVLVRRYLKNNQKFKKTVCTGTKAIVKTLPTGCISDRIWESVCNERSRHEASGHSKALQAIQLQVSRALLAYPGARLAEIDHAAPTLSPEVSLLHRSRKLLAQAVSWPPVSPSQIRFRACHRRISIAAHLSGALLVATAALGARTSLPSFTVGSTGRAMLKERQLCSSMANSSILPSAVTGISKELADLRHLIQFPEEIATILTEQEQQLYRRVFPLDYLSFLTRDLGSPECHKRHPHLKASLSAPIMPTQNDNHNTVEDLVTRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCSWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQADIETMRGLKDAMAQHESSSEYKKVVSRALNIPGCKVVPFCGVFLKELSEALDGAASIIGLRPSFDSQEDPVEFVTDYNGQQHFLQRLGSDGLHSSDKEATVSNILQTIRSCNRSLEAEEPEERAREITVCPKNSFKDKSRNQKGPGTERVLFSIGDLSDSEGDPLETVKDVVDLQTTEDVRGPFSHGTELIPWYVLSLQPDIHQFLLQGATVIHYDPESHLTARCLLRLQPDNCFLTWCKPHSSCSLYGRARTFMGHPASPDHLHIGQPVHCGLSDGLLDLNVVKAVFMGHPGVDVNYVCLQHKLCNMNPGGNGATLLYGLHTTDNRLLHFVAPKHTARMLHEGLQELLNSIRKIRKFPDQRLQWLRKQYVSLYQEDGRFEGPTLAHAIELFGGRRWNMGTSGPGSASRSAEKNSAQKNSPLGINSNVKKKKKALVRGDSGDGTDDEMTARKTRGCKETLGRRESDPLENVEQGEAEDCSTFSQPGPSSLSNNKGQSPGSSSSSSTSSSVASFCTNSSTPTRPHSSPILPTNLKSQPGAWSSRSWHGRGKGCFRGFQDLMISDSIMSFVEFVELFKSFSIRSRKDLKELFDTYAVPCSRSGPESVPLYTTLRIDDKLTGLQPDLDLLTRNGSDLGLFIRTRQQMSENQKQISDAIAAASIVTNGTGVENSSLGVLGLAISQLNDFLVNCQREHLSYDEILSIIQKFEPSSNMRQMGWMSFEGFARFLMDKDNFASKNEESQVNLDELQHPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPVIYHGHTLTTKIPFKDVVEAINRAAFVNSEMPVILSIENHCSLPQQRKMAEIFKMVFGEKLVTKFLFESDFADEPLLPSPLQLRGKILLKNKKLKAHQAPVDILKQKAHQLAHMQAQANNGTVSTTPLGNNDEEEEEEDEYDYDYESLSDDNILDDKPEGKSSTEKLQYESNDEMPKRFKKAGSKGKMFDMELGEEFYLPQNEKESRQIAQELSDLVIYCQAIKFPGLSTLSPSGSGRGKDRKSRKSIFGSAPARGSPGEPVTLVRAPGKASLEGIRMNSEEQMCLSPSTSLSSIIRTPKCYHISSVNENAAKRLCRRYSQKLIQHTSCQLLRTYPAATRIDSANPNPLIFWLHGVQLVALNYQTDDLPMQLNAALFEANGHCGFVLKPPVLWDRSCPLYQHFYPLDRDLENMTPTLYTLTIVSGQNVCPGNSNGSPCVEVEVLGMPADSCHFRTKPIHRNTLNPMWNEHFQFHVHFEDLAFLRIAVVENNSSQVTAQRILPLKTLRAGYRHLQLRNLHNEPLEVSSLFMFSRRTEESPTGGPPSASVLFSTEERRSVQQHKVTVHGVPGPEPFTVICVDEFTTAKQLLDSLFPTASFKYMLMEERVSLSKEKKAPQQRPLANDERLLKLIHSWQPEDGYVGRIYLKTREQQNCSEKTSVPLESLEELGSSEDDTFFVQVHDVSPEQPHTVIKAPRYSTAQDIIQQTLSKAKYSLSILSNPNPCDYVLMEELCKDAGGKKSSSAKPCQRVLQDHECVFQAQSRWKGAGKFILKLKEQLAREDKRKGVSFASELRKLTGRSRSVTVNTNSNDTHSKEEKSACPSMSCVPETSQ

Gene Information

Entrez Gene ID
568288
Gene Name
phospholipase C, epsilon 1
Gene Symbol
plce1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005085 IEA:InterPro F guanyl-nucleotide exchange factor activity
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0032836 IMP:ZFIN P glomerular basement membrane development
GO:0032835 ISS:ZFIN P glomerulus development
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007264 IEA:InterPro P small GTPase mediated signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR028398 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR023578 Ras guanine nucleotide exchange factor domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR000159 Ras-association
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, epsilon 1
Protein Entry
C5H807_DANRE
UniProt ID
C5H807
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Similarity Contains 1 C2 domain.
Similarity Contains 1 PI-PLC X-box domain.
Similarity Contains 1 PI-PLC Y-box domain.
Similarity Contains C2 domain.
Similarity Contains Cdomain.
Similarity Contains PI-PLC X-box domain.
Similarity Contains PI-PLC Y-box domain.
Similarity Contains Ras-GEF domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP012141 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
239582779 RefSeq NP_001155125 2248 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Identical Sequences to LMP012141 proteins

Reference Database Accession Length Protein Name
GI:239582779 GenBank ACL12271.1 2248 phospholipase C epsilon 1 [Danio rerio]

Related Sequences to LMP012141 proteins

Reference Database Accession Length Protein Name
GI:239582779 RefSeq XP_009304697.1 2253 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [Danio rerio]
GI:239582779 RefSeq XP_009304698.1 2253 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [Danio rerio]
GI:239582779 RefSeq XP_009304700.1 2252 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2 [Danio rerio]
GI:239582779 RefSeq XP_009304701.1 2239 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [Danio rerio]
GI:239582779 RefSeq XP_009304702.1 1842 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4 [Danio rerio]
GI:239582779 RefSeq XP_009304703.1 2238 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [Danio rerio]