Gene/Proteome Database (LMPD)

LMPD ID
LMP012108
Gene ID
564511
Species
Danio rerio (Zebrafish)
Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor b
Gene Symbol
vdrb
Synonyms
NR1I1-B; VDRbeta; gb:dq017633
Alternate Names
vitamin D3 receptor B; VDR-B; vitamin D receptor b; vitamin D receptor beta; 1,25-dihydroxyvitamin D3 receptor B; vitamin D (1,25-dihydroxyvitamin D3) receptor; nuclear receptor subfamily 1 group I member 1-B
Chromosome
6

Proteins

vitamin D3 receptor B
Refseq ID NP_001153457
Protein GI 229606097
UniProt ID Q1L673
mRNA ID NM_001159985
Length 422
RefSeq Status VALIDATED
MESAVSTSTQVPDEFDRNVPRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGSCTITKDNRRHCQACRLKRCLDIGMMKEFILTDEEVQRKKELIQRRKDEEAHREAQKPRLSDEQRNIIDTLVDAHHKTYDDSYSDFSRFRPPVREGPVTRSASRAASLHSLSDASSDSFSHSPESGDRKMNLSNLLMMYQEQGLSSSPDSKEEDGSSLSMLPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFSLEDMSWSCGGPEFKYCVNDVTKAGHTLELLEPLVKFQVGLKKLNLHEEEHVLLMAICLLSPDRPGVQDHVRVEALQDKVSEVLQAYIRAHHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGGQVT

Gene Information

Entrez Gene ID
564511
Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor b
Gene Symbol
vdrb
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0008434 IEA:InterPro F calcitriol receptor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding

REACTOME Pathway Links

REACTOME Pathway ID Description
6176482 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR000324 Vitamin D receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor b
Protein Entry
VDRB_DANRE
UniProt ID
Q1L673
Species
Zebrafish

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. {ECO:0000250}.
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis (By similarity). {ECO:0000250}.
Similarity Belongs to the nuclear hormone receptor family. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes. {ECO:0000250}.
Tissue Specificity Detected in embryo 24 to 48 hours after fertilization, and in intestinal bulb. {ECO:0000269|PubMed:17997606}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012108 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
229606097 RefSeq NP_001153457 422 vitamin D3 receptor B

Identical Sequences to LMP012108 proteins

Reference Database Accession Length Protein Name
GI:229606097 RefSeq XP_005166104.1 422 PREDICTED: vitamin D3 receptor B isoform X1 [Danio rerio]
GI:229606097 SwissProt Q1L673.2 422 RecName: Full=Vitamin D3 receptor B; Short=VDR-B; AltName: Full=1,25-dihydroxyvitamin D3 receptor B; AltName: Full=Nuclear receptor subfamily 1 group I member 1-B [Danio rerio]

Related Sequences to LMP012108 proteins

Reference Database Accession Length Protein Name
GI:229606097 GenBank AAY85288.1 419 VDR-B, partial [Danio rerio]
GI:229606097 GenBank AIM62162.1 422 vitamin D receptor beta [Danio rerio]
GI:229606097 RefSeq XP_007249184.1 421 PREDICTED: vitamin D3 receptor B-like isoform X1 [Astyanax mexicanus]
GI:229606097 RefSeq XP_007249185.1 421 PREDICTED: vitamin D3 receptor B-like isoform X2 [Astyanax mexicanus]
GI:229606097 RefSeq XP_007249186.1 421 PREDICTED: vitamin D3 receptor B-like isoform X3 [Astyanax mexicanus]
GI:229606097 RefSeq XP_007249187.1 421 PREDICTED: vitamin D3 receptor B-like isoform X4 [Astyanax mexicanus]