Gene/Proteome Database (LMPD)

LMPD ID
LMP012055
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
Synonyms
PGIS; ptgisl
Chromosome
6

Proteins

prostacyclin synthase
Refseq ID NP_001104630
Protein GI 162287256
UniProt ID A9LLA5
mRNA ID NM_001111160
Length 480
RefSeq Status PROVISIONAL
MMWTALLLVGLSILVIVLYGRRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQGGKHLRLEERQKNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIRF

Gene Information

Entrez Gene ID
Gene Name
prostaglandin I2 (prostacyclin) synthase
Gene Symbol
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:UniProtKB-SubCell C endoplasmic reticulum membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:InterPro F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0008116 IEA:UniProtKB-EC F prostaglandin-I synthase activity

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

UniProt Annotations

Entry Information

Gene Name
prostaglandin I2 (prostacyclin) synthase
Protein Entry
A9LLA5_DANRE
UniProt ID
Species
Zebrafish

Comments

Comment Type Description
Cofactor Note=Heme group. {ECO:0000256|PIRNR:PIRNR000047, ECO:0000256|PIRSR:PIRSR000047-1};
Similarity Belongs to the cytochrome P450 family.
Subcellular Location Endoplasmic reticulum membrane .

Identical and Related Proteins

Unique RefSeq proteins for LMP012055 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
162287256 RefSeq NP_001104630 480 prostacyclin synthase

Identical Sequences to LMP012055 proteins

Reference Database Accession Length Protein Name
GI:162287256 GenBank ABX51998.1 480 prostaglandin I2 synthase [Danio rerio]

Related Sequences to LMP012055 proteins

Reference Database Accession Length Protein Name
GI:162287256 GenBank ABC59225.1 480 prostacyclin synthase, partial [Danio rerio]
GI:162287256 GenBank ABC87983.1 477 prostacyclin synthase [Pimephales promelas]
GI:162287256 PDB 3B98 475 Chain A, Crystal Structure Of Zebrafish Prostacyclin Synthase (Cytochrome P450 8a1)
GI:162287256 PDB 3B98 475 Chain B, Crystal Structure Of Zebrafish Prostacyclin Synthase (Cytochrome P450 8a1)
GI:162287256 PDB 3B99 475 Chain A, Crystal Structure Of Zebrafish Prostacyclin Synthase (Cytochrome P450 8a1) In Complex With Substrate Analog U51605
GI:162287256 PDB 3B99 475 Chain B, Crystal Structure Of Zebrafish Prostacyclin Synthase (Cytochrome P450 8a1) In Complex With Substrate Analog U51605