Gene/Proteome Database (LMPD)

LMPD ID
LMP011963
Gene ID
553051
Species
Danio rerio (Zebrafish)
Gene Name
fermitin family member 2
Gene Symbol
fermt2
Synonyms
PLEKHC1; im:7145859
Alternate Names
fermitin family homolog 2; KIND2; kindlin-2; pleckstrin homology domain containing, family C (with FERM domain) member 1
Chromosome
17

Proteins

fermitin family homolog 2
Refseq ID NP_001243144
Protein GI 371940942
UniProt ID F1Q8X5
mRNA ID NM_001256215
Length 684
RefSeq Status VALIDATED
MALDGIRMPDGCYADGTWELKMHVTDLNRDVSLRVTGEIHIGGVMLKLVEKLDVKKDWSDHALWWEKKKTWLLKTHWTLDKYGIQADARLLFTPQHKLLRLQLPNMKHMRVKVNFSDRVFKAVSDICKTFNIRHPEELSLLRKPRDPKKKKKKLEDAEEETLELEGPLLTPGSGSIYSSPGLYSKTMTPTYDSRDGSPLSPTSAWFGDSPLSEGNPSILAVSQPITSPDILVKMYKPQSLLDKAKINQGWLDSSRSLMEQDVKENEVLLLRFKYHSFFDLNPKYDAIRVNQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMSSDNHMNNSEKEVDEVDAALSDLEITLEGGKTSNTLGDITSIPELADYVKVFKPKKLTLKGYKQYWCTFKDITISCYKSREEAHGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVADGMNEIWLRCDTEKQYAQWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHMNPDPQIIEPITTDINPECLVSPRYLKKYKNKQPGFVRDLISARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFLAKFQGGKKDELIGITYNRLIRMDAGTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEPSLAFICAEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV

Gene Information

Entrez Gene ID
553051
Gene Name
fermitin family member 2
Gene Symbol
fermt2
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042995 IEA:UniProtKB-KW C cell projection
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0014704 IMP:ZFIN C intercalated disc
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0016055 IEA:UniProtKB-KW P Wnt signaling pathway
GO:0001525 IMP:ZFIN P angiogenesis
GO:0055008 IMP:ZFIN P cardiac muscle tissue morphogenesis
GO:0007155 IEA:UniProtKB-KW P cell adhesion
GO:0007010 IMP:ZFIN P cytoskeleton organization
GO:0008360 IEA:UniProtKB-KW P regulation of cell shape

REACTOME Pathway Links

REACTOME Pathway ID Description
6176575 Cell junction organization
6176463 Cell-Cell communication
6176611 Cell-extracellular matrix interactions

Domain Information

InterPro Annotations

Accession Description
IPR019749 Band 4.1 domain
IPR019748 FERM central domain
IPR018979 FERM, N-terminal
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
fermitin family member 2
Protein Entry
FERM2_DANRE
UniProt ID
F1Q8X5
Species
Zebrafish

Comments

Comment Type Description
Disruption Phenotype Morpholino knockdown results in severe defects in embryonic development. Nearly all embyos display pericardial edema. Most embryos display abnormal body shape and size, defects in heart morphogenesis, impaired mobility, and die at about 7 dpf. The embryonic cardiac muscle and skeletal muscle show defects in the association of the actin-myosin myofibers with the myocyte membrane (PubMed:18174465). Likewise, morpholino knockdown results in defective angiogenesis, with abnormally short and thin vessels and very little blood flow (PubMed:21378273). {ECO:0000269|PubMed:18174465, ECO:0000269|PubMed:21378273}.
Domain The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
Domain The N-terminal region displays a ubiquitin-type fold and mediates interaction with membranes containing negatively charged phosphatidylinositol phosphate via a surface enriched in positively charged residues. {ECO:0000250}.
Domain The PH domain binds phospholipids. Binds preferentially phosphatidylinositol-3,4,5-trisphosphate, and has lower affinity for phosphatidylinositol-4,5-bisphosphate (By similarity). {ECO:0000250}.
Function Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling (By similarity). Required for normal embryonic development, including normal heart morphogenesis and normal angiogenesis. {ECO:0000250, ECO:0000269|PubMed:18174465, ECO:0000269|PubMed:21378273}.
Similarity Belongs to the kindlin family. {ECO:0000305}.
Similarity Contains 1 FERM domain. {ECO:0000305}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell- ECM focal adhesion sites. Colocalizes with integrins at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011963 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
371940942 RefSeq NP_001243144 684 fermitin family homolog 2

Identical Sequences to LMP011963 proteins

Reference Database Accession Length Protein Name
GI:371940942 SwissProt F1Q8X5.1 684 RecName: Full=Fermitin family homolog 2; AltName: Full=Kindlin-2 [Danio rerio]

Related Sequences to LMP011963 proteins

Reference Database Accession Length Protein Name
GI:371940942 RefSeq XP_003962569.1 684 PREDICTED: fermitin family homolog 2-like isoform 2 [Takifugu rubripes]
GI:371940942 RefSeq XP_004082246.1 684 PREDICTED: fermitin family homolog 2-like [Oryzias latipes]
GI:371940942 RefSeq XP_005158972.1 695 PREDICTED: fermitin family homolog 2 isoform X1 [Danio rerio]
GI:371940942 RefSeq XP_005158973.1 688 PREDICTED: fermitin family homolog 2 isoform X2 [Danio rerio]
GI:371940942 RefSeq XP_005158974.1 677 PREDICTED: fermitin family homolog 2 isoform X3 [Danio rerio]
GI:371940942 RefSeq XP_008275116.1 695 PREDICTED: fermitin family homolog 2 isoform X1 [Stegastes partitus]