Gene/Proteome Database (LMPD)

LMPD ID
LMP011866
Gene ID
447912
Species
Danio rerio (Zebrafish)
Gene Name
vac14 homolog (S. cerevisiae)
Gene Symbol
vac14
Synonyms
fb68e05; wu:fb68e05; zgc:100945
Alternate Names
protein VAC14 homolog
Chromosome
25

Proteins

protein VAC14 homolog
Refseq ID NP_001004650
Protein GI 57768939
UniProt ID Q66L58
mRNA ID NM_001004650
Length 771
RefSeq Status PROVISIONAL
MNTEKDFSPLTPNIVRALNDKLYEKRKVAALEIEKLVREFVAQNNSAQIRHVIQILATEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIDPVLTCFNDSDSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESNKFDLVAFVPLLRERIYSNNQYARQFIISWIHVLESVPDINLLDYLPEILDGLFQILGDSSKEIRRMCELVLGEFLKEIKKNPSSVKFAEMANILVIHCQVSDESKSTNDLIQLTSMTWMREFIQLAGRVVLPYSSGILTAVLPCLSYDDRKKSTKEAASACNHSLMKLVTPEDDEDDEESQTKSSPPSDEAPSKKEGDLNDSLNESQESVGFSNISFFTPASSDRSAVTLDLDGIVQVLDRHLHDSSTGMMTRIAVLKWLYHLYIKTPRKMFKHTDSLFPMLLKTLSDESDEVILKDLEVLAEIASSPAGQTDTSGSCDISDSKTELHIPGSKMTDLSPSTPSMNSYFYKFMINLLKRFSLERKLLEMRGAFIIRQLCLLLHAENIFHSMADILLKEEDLKFASTMVQTLNTILLTSAELFQLRNQLKDLRTQESCALFCCLYRSWCHNPVATVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLMEVDKLVQLIESPIFTYLRLQLLDVEHNPYLIKALYGLLMLLPQSQAFQLLSHRLSCVPNPELMRTLEDQKVAVKDKHLAQPHIDYSELLQHFDRVQSKHLEVRHQRTGRSEHPDRKLM

Gene Information

Entrez Gene ID
447912
Gene Name
vac14 homolog (S. cerevisiae)
Gene Symbol
vac14
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070772 IEA:InterPro C PAS complex
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0043550 IEA:InterPro P regulation of lipid kinase activity

REACTOME Pathway Links

REACTOME Pathway ID Description
6176801 PI Metabolism
6176822 Synthesis of PIPs at the Golgi membrane
6176823 Synthesis of PIPs at the early endosome membrane
6176820 Synthesis of PIPs at the late endosome membrane

Domain Information

InterPro Annotations

Accession Description
IPR011989 Armadillo-like helical
IPR016024 Armadillo-type fold
IPR021841 Vacuolar protein 14 C-terminal Fig4-binding domain
IPR026825 Vacuole morphology and inheritance protein 14

UniProt Annotations

Entry Information

Gene Name
vac14 homolog (S. cerevisiae)
Protein Entry
VAC14_DANRE
UniProt ID
Q66L58
Species
Zebrafish

Comments

Comment Type Description
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity (By similarity). {ECO:0000250}.
Similarity Belongs to the VAC14 family. {ECO:0000305}.
Similarity Contains 6 HEAT repeats. {ECO:0000305}.
Subcellular Location Endosome membrane {ECO:0000250}.
Subunit Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011866 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57768939 RefSeq NP_001004650 771 protein VAC14 homolog

Identical Sequences to LMP011866 proteins

Reference Database Accession Length Protein Name
GI:57768939 GenBank AAH78425.1 771 Vac14 homolog (S. cerevisiae) [Danio rerio]
GI:57768939 SwissProt Q66L58.1 771 RecName: Full=Protein VAC14 homolog [Danio rerio]

Related Sequences to LMP011866 proteins

Reference Database Accession Length Protein Name
GI:57768939 EMBL CAG12165.1 785 unnamed protein product, partial [Tetraodon nigroviridis]
GI:57768939 EMBL CDQ61631.1 783 unnamed protein product [Oncorhynchus mykiss]
GI:57768939 RefSeq XP_005942364.1 790 PREDICTED: protein VAC14 homolog [Haplochromis burtoni]
GI:57768939 RefSeq XP_008289379.1 784 PREDICTED: protein VAC14 homolog [Stegastes partitus]
GI:57768939 RefSeq XP_008327808.1 787 PREDICTED: protein VAC14 homolog [Cynoglossus semilaevis]
GI:57768939 RefSeq XP_009296175.1 782 PREDICTED: protein VAC14 homolog isoform X1 [Danio rerio]